2-Chloroadenosine
Chemical Name: 6-Amino-2-chloropurine riboside
Purity: ≥98%
Biological Activity
2-Chloroadenosine is a metabolically stable analog of adenosine that behaves as an adenosine receptor agonist (Ki values are 300, 80 and 1900 nM for A1, A2A and A3 receptors respectively). Anticonvulsive in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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N-type voltage gated calcium channels mediate excitatory synaptic transmission in the anterior cingulate cortex of adult mice.
Kang S, Liu M, Shi T, Zhao M, Kaang B, Zhuo M
Mol Pain, 2013;9(0):58. -
Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo.
Mathot et al.
Br.J.Pharmacol., 1996;118:369 -
Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures.
Pourgholami et al.
Brain Res., 1997;775:37 -
The protective effect of 2-chloroadenosine against the development of amygdala kindling and on amygdala-kindled seizures.
Abdul-Ghani et al.
Eur.J.Pharmacol., 1997;326:7
Product Datasheets
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Citation for 2-Chloroadenosine
The citations listed below are publications that use Tocris products. Selected citations for 2-Chloroadenosine include:
1 Citation: Showing 1 - 1
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The A2aR adenosine receptor controls cytokine production in iNKT cells.
Authors: Nowak Et al.
Front Cell Neurosci 2010;40:682
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