Home / Gap Channel Blockers / 10Panx

10Panx

Catalog #: 3348
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3348/1
10Panx
1 Image
Description: Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions

Purity: ≥95%

Product Details
Citations (8)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

10Panx is a panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%.

Technical Data

M.Wt:
1242.37
Formula:
C58H79N15O16
Sequence:
WRQAAFVDSY
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
955091-53-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The P2X7 Receptor Primes IL-1? and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain
    F Albalawi, W Lu, JM Beckel, JC Lim, SA McCaughey, CH Mitchell
    Front Cell Neurosci, 2017;11(0):227.
  2. CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process.
    Melhorn M, Brodsky A, Estanislau J, Khoory J, Illigens B, Hamachi I, Kurishita Y, Fraser A, Nicholson-Weller A, Dolmatova E, Duffy H, Ghiran I
    J Biol Chem, 2013;288(43):31139-53.
  3. Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis
    J Boucher, C Simonneau, G Denet, J Clarhaut, AC Balandre, M Mesnil, L Cronier, A Monvoisin
    Int J Mol Sci, 2018;19(6):.
  4. Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression.
    Fritsche G, Nairz M, Libby S, Fang F, Weiss G
    J Leukoc Biol, 2012;92(2):353-9.
  5. A central role for P2X7 receptors in human microglia
    L Janks, CVR Sharma, TM Egan
    J Neuroinflammation, 2018;15(1):325.
  6. Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X7 receptor.
    Pelegrin and Surprenant
    EMBO J., 2006;25:5071
  7. Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.
    Wang et al.
    Am.J.Physiol.Cell Physiol., 2007;293:C1112
  8. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.
    Thompson et al.
    Science, 2008;322:1555

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for 10Panx

The citations listed below are publications that use Tocris products. Selected citations for 10Panx include:

8 Citations: Showing 1 - 8

  1. Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis.
    Authors: Chen Et al.
    Sci Rep  2019;9:160
  2. Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.
    Authors: Hudson Et al.
    J Pharmacol Exp Ther  2019;370:44
  3. Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes.
    Authors: Barría Et al.
    Am J Trop Med Hyg  2018;98:105
  4. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
    Authors: Kleiner Et al.
    Mol Vis  2018;24:647
  5. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.
    Authors: Albalawi Et al.
    Front Cell Neurosci  2017;11:227
  6. Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells.
    Authors: Kowal Et al.
    Cell Metab  2015;13:28
  7. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2.
    Authors: Adamczyk Et al.
    J Cell Sci  2015;128:4615
  8. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol  2012;92:787

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for 10Panx

There are currently no reviews for this product. Be the first to review 10Panx and earn rewards!

Have you used 10Panx?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.