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10-DEBC hydrochloride

Catalog #: 2558
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2558/10
2558/50
10-DEBC hydrochloride | CAS No. 925681-41-0 | Akt (Protein Kinase B) Inhibitors
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Description: Selective Akt/PKB inhibitor
Alternative Names: Akt Inhibitor X

Chemical Name: 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride

Purity: ≥99%

Product Details
Citations (6)
Supplemental Products
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

10-DEBC hydrochloride is a selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.

Technical Data

M.Wt:
381.34
Formula:
C20H25N2OCl.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
925681-41-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells.
    Thimmaiah et al.
    J.Med.Chem., 1992;35:3358
  2. Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.
    Thimmaiah et al.
    J.Biol.Chem., 2005;36:31924

Product Datasheets

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Citations for 10-DEBC hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 10-DEBC hydrochloride include:

6 Citations: Showing 1 - 6

  1. TOR as a Regulatory Target in Rhipicephalus microplus Embryogenesis.
    Authors: Waltero Et al.
    Front Physiol  2019;10:965
  2. Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1.
    Authors: Ali Et al.
    BMC Cancer  2017;17:803
  3. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.
    Authors: Liddell Et al.
    J Neuroinflammation  2016;13:49
  4. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling.
    Authors: Sokołowska Et al.
    PLoS One  2014;52:48
  5. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
    Authors: Gangoiti Et al.
    Biochimie  2012;94:597
  6. Inhibition of hepcidin transcription by growth factors.
    Authors: Goodnough Et al.
    Hepatology  2012;56:291

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