proTAME
Newer Version Available:
7734
NEW
Cell-permeable APC/C inhibitor. The new catalog number will be 7734
proTAME Summary
Specifications
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species
Product Datasheets
Citations for proTAME
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
20
Citations: Showing 1 - 10
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Targeting the anaphase-promoting complex/cyclosome (APC/C) enhanced antiproliferative and apoptotic response in bladder cancer
Authors: H Sevim Nalk, D Akcora Yil, F Saydam, AI Guzel, I Nalkiran
Saudi journal of biological sciences, 2023-01-23;30(3):103564. 2023-01-23
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A mitotic chromatin phase transition prevents perforation by microtubules
Authors: MWG Schneider, BA Gibson, S Otsuka, MFD Spicer, M Petrovic, C Blaukopf, CCH Langer, P Batty, T Nagaraju, LK Doolittle, MK Rosen, DW Gerlich
Nature, 2022-08-03;0(0):. 2022-08-03
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Self-assembly of pericentriolar material in interphase cells lacking centrioles
Authors: F Chen, J Wu, MK Iwanski, D Jurriens, A Sandron, M Pasolli, G Puma, JZ Kromhout, C Yang, W Nijenhuis, LC Kapitein, F Berger, A Akhmanova
Elife, 2022-07-05;11(0):. 2022-07-05
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Epigenetic, genetic and maternal effects enable stable centromere inheritance
Authors: A Das, A Iwata-Otsu, A Destouni, JM Dawicki-Mc, KG Boese, BE Black, MA Lampson
Nature Cell Biology, 2022-05-09;24(5):748-756. 2022-05-09
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Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation
Authors: S Carvalhal, I Bader, MA Rooimans, AB Oostra, JA Balk, RG Feichtinge, C Beichler, MR Speicher, JM van Hagen, Q Waisfisz, M van Haelst, M Bruijn, A Tavares, JA Mayr, RMF Wolthuis, RA Oliveira, J de Lange
Science Advances, 2022-01-19;8(3):eabk0114. 2022-01-19
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The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assembly
Authors: T Tischer, J Yang, D Barford
Journal of Cell Science, 2022-01-18;0(0):. 2022-01-18
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A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
Authors: C Thomas, B Wetherall, MD Levasseur, RJ Harris, ST Kerridge, JMG Higgins, OR Davies, S Madgwick
Nature Communications, 2021-07-14;12(1):4322. 2021-07-14
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The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance
Authors: S Zhang, Y Shen, H Li, C Bi, Y Sun, X Xiong, W Wei, Y Sun
Cell Rep, 2020-09-08;32(10):108102. 2020-09-08
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CRISPR-mediated gene targeting of CK1&delta/&epsilon leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1
Authors: RX Guillen, JR Beckley, JS Chen, KL Gould
Sci Rep, 2020-04-22;10(1):6797. 2020-04-22
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ProTAME Arrest in Mammalian Oocytes and Embryos Does Not Require Spindle Assembly Checkpoint Activity
Authors: L Radonova, T Svobodova, M Skultety, O Mrkva, L Libichova, P Stein, M Anger
Int J Mol Sci, 2019-09-13;20(18):. 2019-09-13
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Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability
Authors: M Raab, M Sanhaji, S Zhou, F Rödel, A El-Balat, S Becker, K Strebhardt
Neoplasia, 2019-03-07;21(4):363-375. 2019-03-07
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The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence
Authors: AJ Bainor, S Saini, A Calderon, R Casado-Pol, B Giner-Rami, C Moncada, DJ Cantor, A Ernlund, L Litovchick, G David
Cell Rep, 2018-12-04;25(10):2797-2807.e8. 2018-12-04
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EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle
Authors: SD Cappell, KG Mark, D Garbett, LR Pack, M Rape, T Meyer
Nature, 2018-06-06;0(0):. 2018-06-06
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ATP depletion during mitotic arrest induces mitotic slippage and APC/CCdh1-dependent cyclin B1 degradation
Authors: YY Park, JH Ahn, MG Cho, JH Lee
Exp. Mol. Med., 2018-04-27;50(4):46. 2018-04-27
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Reciprocal Regulation between 53BP1 and the Anaphase-Promoting Complex/Cyclosome Is Required for Genomic Stability during Mitotic Stress
Authors: TJ Kucharski, PE Minshall, M Moustafa-K, AS Turnell, JG Teodoro
Cell Rep, 2017-02-21;18(8):1982-1995. 2017-02-21
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APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry
Cell Rep, 2016-09-20;16(12):3359-72. 2016-09-20
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AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest.
Authors: Domenech E, Maestre C, Esteban-Martinez L, Partida D, Pascual R, Fernandez-Miranda G, Seco E, Campos-Olivas R, Perez M, Megias D, Allen K, Lopez M, Saha A, Velasco G, Rial E, Mendez R, Boya P, Salazar-Roa M, Malumbres M
Nat Cell Biol, 2015-08-31;17(10):1304-16. 2015-08-31
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Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.
Authors: Boekhout M, Wolthuis R
J Cell Sci, 2015-02-11;128(8):1639-53. 2015-02-11
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APC/C is an essential regulator of centrosome clustering.
Authors: Drosopoulos, Konstant, Tang, Chan, Chao, William, Linardopoulos, Spiros
Nat Commun, 2014-04-22;5(0):3686. 2014-04-22
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Microtubule-dependent regulation of mitotic protein degradation.
Authors: Song L, Craney A, Rape M
Mol Cell, 2014-01-23;53(2):179-92. 2014-01-23
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