Mouse IL‑12/IL‑23 p40 Biotinylated Antibody Summary
Met23-Ser355
Accession # P43432
Applications
Mouse IL-12/IL-23 p40 Allele-specific Sandwich Immunoassay
Mouse IL-23 Sandwich Immunoassay
Mouse IL-12/IL-23 p40 Nonallele-specific Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-12/IL-23 p40
Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. IL-12 has multiple effects on T cells and NK cells and is a key mediator in the development of Th1 cells. IL-12 is a heterodimeric cytokine containing two disulfide-linked subunits, p35 and p40. Human and mouse IL-12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. Although mouse IL-12 is active on human or mouse IL-12 responsive cells, human IL-12 is not active on mouse cells. The disulfide-linked mouse p40 homodimer can bind to IL-12 receptors and is an antagonist of IL-12 activities in vitro. The mouse p40 monomer is at least ten times less active than the homodimer as an IL-12 antagonist. At the present time, the existence and the physiological role of mouse p40 homodimer in vivo remains to be determined.
Product Datasheets
Citations for Mouse IL‑12/IL‑23 p40 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells
Authors: Seon-Yeong Lee, Su-Jin Moon, Young-Mee Moon, Hyeon-Beom Seo, Jun-Geol Ryu, A Ram Lee et al.
Cellular & Molecular Immunology
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Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rbeta1 and subsequent signal transduction
Authors: J Georgy, Y Arlt, JM Moll, M Ouzin, HT Weitz, L Gremer, D Willbold, J Grötzinger, F Thives-Kur, J Scheller, DM Floss
The Journal of Biological Chemistry, 2021-10-09;0(0):101295.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1
Genes Dev, 2016-05-01;30(9):1070-85.
Species: Human
Sample Types: Recombinant Protein
Applications: Western Blot -
IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice.
Authors: Flores R, Kim E, Zhou L, Yang C, Zhao J, Gambotto A, Robbins P
Eur J Immunol, 2015-09-01;45(11):3114-25.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Direct ELISA -
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production.
Authors: Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ
Proc. Natl. Acad. Sci. U.S.A., 2009-03-16;106(14):5954-9.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA Development -
Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages.
Authors: An HJ, Jeong HJ, Um JY, Kim HM, Hong SH
J Ethnopharmacol, 2006-03-10;106(3):418-24.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells.
Authors: Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA
Blood, 2004-05-13;104(5):1404-10.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.
Authors: Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ
Am. J. Pathol., 2002-04-01;160(4):1353-60.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA Development
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