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OAC-1

Catalog #: 4887 Datasheet / COA / SDS

Discontinued Product

4887 has been discontinued.
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OAC-1 | CAS No. 300586-90-7 | Additional Stem Cell Dedifferentiation Products
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Description: Oct4 activator; enhances iPSC reprogramming efficiency

Chemical Name: N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide

Purity: ≥98%

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Biological Activity

OAC-1 is a Oct4 activator. Enhances and accelerates iPSC reprogramming in the presence of 4F (Oct4, Sox2, c-Myc and Klf4) by ~20-fold compared to 4F alone. Induces mRNA expression of Oct4, Sox2 and Nanog and also Tet1. Displays no effects on p53-p21 pathway or Wnt-β-catenin signaling.

Technical Data

M.Wt:
237.26
Formula:
C14H11N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
300586-90-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of Oct4-activating compounds that enhance reprogramming efficiency.
    Li et al.
    Proc.Natl.Acad.Sci.USA., 2012;109:20853

Product Datasheets

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