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Recombinant Mouse XCL1/Lymphotactin Protein

Catalog #: 486-LT
8 Citations Datasheet / COA / SDS

Discontinued Product

486-LT has been discontinued.
View all XCL1/Lymphotactin products.
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Citations (8)
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Recombinant Mouse XCL1/Lymphotactin Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human XCR1. The ED50 for this effect is 0.05‑0.1 µg/mL.
Source
E. coli-derived mouse XCL1/Lymphotactin protein
Val22-Gly114, with an N-terminal Met
Accession #
AAA56752.1
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
10 kDa

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486-LT (with carrier)

Product Datasheet
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486-LT/CF (carrier free)

Discontinued Product

486-LT

Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: XCL1/Lymphotactin

Mouse lymphotactin (Lptn) and its human homologue (also named human SCM-1 and ATAC) belong to the C or gamma subfamily of chemokines. The C chemokines lack two (the 1st and 3rd) of the four invariant cysteine residues normally found in the CC and CXC chemokines and have an extended carboxy terminus. Mouse lymphotactin encodes a 114 amino acid residue precursor protein with a 21 amino acid residue predicted signal peptide. The expression of lymphotactin is restricted to activated mouse pro-T cells and to activated, class I MHC restricted T cells. The gene for lymphotactin has been mapped to chromosome 1 in both human and mouse. Recombinant mouse lymphotactin has been shown to have chemotactic activity for lymphocytes, NK cells and mouse splenocytes.

References
  1. Kelner, G. et al. (1994) Science 266:1395.
  2. Hedrick, J.A. et al. (1997) J. Immunol. 158:1533.
Long Name
Chemokine [C Motif] Ligand 1
Entrez Gene IDs
6375 (Human); 16963 (Mouse)
Alternate Names
ATAC; ATACSmall-inducible cytokine C1; C motif chemokine 1; chemokine (C motif) ligand 1; Cytokine SCM-1; LPTNSCM-1-alpha; LTNXC chemokine ligand 1; Lymphotactin; lymphotaxin; SCM-1 alpha; SCM-1; SCM1A; SCM-1a; SCYC1SCM1; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); XCL1

Citations for Recombinant Mouse XCL1/Lymphotactin Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. Anticancer effects of chemokine-directed antigen delivery to a cross-presenting dendritic cell subset with immune checkpoint blockade
    Authors: Y Mizumoto, H Hemmi, M Katsuda, M Miyazawa, Y Kitahata, A Miyamoto, M Nakamori, T Ojima, K Matsuda, M Nakamura, K Hayata, Y Fukuda-Oht, M Sugiyama, T Ohta, T Orimo, S Okura, I Sasaki, K Tamada, H Yamaue, T Kaisho
    Br. J. Cancer, 2020-02-18;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  2. Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity
    Authors: S Sharif, N Ueda, Y Nakatani, LM Wise, S Clifton, Z Lateef, AA Mercer, SB Fleming
    Front Microbiol, 2019-06-25;10(0):1421.
    Species: Mouse
    Sample Types:
    Applications: Binding Assay
  3. NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control
    Authors: JP Böttcher, E Bonavita, P Chakravart, H Blees, M Cabeza-Cab, S Sammicheli, NC Rogers, E Sahai, S Zelenay, C Reis E Sou
    Cell, 2018-02-08;172(5):1022-1037.e14.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine
    Authors: K Li, G Wei, Y Cao, D Li, P Li, J Zhang, H Bao, Y Chen, Y Fu, P Sun, X Bai, X Ma, Z Lu, Z Liu
    PLoS ONE, 2017-01-27;12(1):e0170575.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Viral semaphorin inhibits dendritic cell phagocytosis and migration but is not essential for gammaherpesvirus-induced lymphoproliferation in malignant catarrhal fever.
    Authors: Myster F, Palmeira L, Sorel O, Bouillenne F, DePauw E, Schwartz-Cornil I, Vanderplasschen A, Dewals B
    J Virol, 2015-01-14;89(7):3630-47.
    Species: Ovine
    Sample Types: Whole Cells
    Applications: Bioassay
  6. A parenteral DNA vaccine protects against pneumonic plague.
    Authors: Yamanaka H, Hoyt T, Yang X, Bowen R, Golden S, Crist K, Becker T, Maddaloni M, Pascual DW
    Vaccine, 2010-03-01;28(18):3219-30.
    Applications: ELISA (Standard)
  7. Exercise enhances vaccine-induced antigen-specific T cell responses.
    Authors: Rogers CJ, Zaharoff DA, Hance KW, Perkins SN, Hursting SD, Schlom J, Greiner JW
    Vaccine, 2008-08-14;26(42):5407-15.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  8. XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability.
    Authors: Ordway D, Higgins DM, Sanchez-Campillo J, Spencer JS, Henao-Tamayo M, Harton M, Orme IM, Gonzalez Juarrero M
    J. Leukoc. Biol., 2007-08-15;82(5):1221-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

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