Recombinant Mouse CXCL15/Lungkine Protein Summary
Product Specifications
Gln26-Ala167, with an N-terminal Met
Analysis
Product Datasheets
442-LK
| Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Reconstitution Calculator
Background: CXCL15/Lungkine
Mouse Lungkine/CXCL15 (1), also named WECHE (2), is a member of the ELR motif-containing CXC chemokines. The cDNA of mouse Lungkine encodes a protein of 167 amino acids (aa) with a 25 aa predicted signal peptide and a 142 aa mature protein with an extremely long C terminal tail that protrudes beyond the chemokine fold. Mouse Lungkine shares 35% aa sequence identity with human ENA-78 and 31% identity with human IL-8. The gene for mouse Lungkine has been mapped to chromosome 5. By Northern blot and in situ hybridization, Lungkine transcripts are only specifically detected in the adult and fetal lung, and its expression is up-regulated under inflammatory conditions (1). Lungkine protein is secreted into bronchoalveolar space and is involved in lung-specific neutrophils trafficking (1). Studies from Lungkine knock out mice suggests that Lungkine is an important mediator of neutrophil migration from the lung parenchyma into the airspace (3). Lungkine is also chemotactic for bone marrow progenitor cells and modulates hematopoietic cell differentiation (2).
Citations for Recombinant Mouse CXCL15/Lungkine Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-kappaB signaling pathway
Authors: H Xiong, J Ye, K Xie, W Hu, N Xu, H Yang
Lipids in Health and Disease, 2022-12-29;21(1):147.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation
Authors: YM Hyun, SU Seo, WS Choi, HJ Kwon, DY Kim, S Jeong, GY Kang, E Yi, M Kim, HJ Ryu, MR Looney, EY Choi, HS Kim
Sci Adv, 2020-11-06;6(45):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TGFbeta signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions.
Authors: Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, Novitskiy S
PLoS ONE, 2015-01-28;10(1):e0117908.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The role of CCL21 in recruitment of T-precursor cells to fetal thymi.
Authors: Ueno T, Kuse S, Saito F, Nitta T, Kakiuchi T, Hollander GA, Takahama Y
Blood, 2004-09-09;105(1):31-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Circulating CXC-chemokine concentrations in a murine intestinal ischemia-reperfusion model.
Authors: Maheshwari A, Christensen RD, Calhoun DA
Fetal Pediatr Pathol, 2004-03-01;23(2):145-57.
Applications: ELISA (Standard)
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