Recombinant Mouse Cardiotrophin-1/CT-1 Protein
Recombinant Mouse Cardiotrophin-1/CT-1 Protein Summary
Product Specifications
Ser2-Ala203
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
438-CT
| Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
438-CT/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile 4 mM HCl. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: Cardiotrophin-1/CT-1
Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT-1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Mouse CT-1 encodes a 203 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. The mechanism of CT-1 release from cells is currently not understood. Human and mouse CT-1 share 80% aa sequence identity and exhibit cross‑species activity. CT-1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels of CT-1 expression is also seen in testis and brain. CT-1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor beta subunit. A third alpha receptor subunit has also been implicated in the receptor complex.
Citations for Recombinant Mouse Cardiotrophin-1/CT-1 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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Induction of Stem-Cell-Derived Cardiomyogenesis by Fibroblast Growth Factor 10 (FGF10) and Its Interplay with Cardiotrophin-1 (CT-1)
Authors: F Khosravi, N Ahmadvand, M Wartenberg, H Sauer
Biology, 2022-03-30;11(4):.
Species: Mouse
Sample Types: Spheroid
Applications: Bioassay -
Maintenance of the Undifferentiated State in Myogenic Progenitor Cells by TGFbeta Signaling is Smad Independent and Requires MEK Activation
Authors: T Miyake, A Aziz, JC McDermott
Int J Mol Sci, 2020-02-05;21(3):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons
Authors: S Schaller, D Buttigieg, A Alory, A Jacquier, M Barad, M Merchant, D Gentien, P de la Gran, G Haase
Proc. Natl. Acad. Sci. U.S.A, 2017-03-07;114(12):E2486-E2493.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nuclear function of Smad7 promotes myogenesis.
Authors: Miyake T, Alli NS, McDermott JC
Mol. Cell. Biol., 2009-12-07;30(3):722-35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling.
Authors: Walker EC, McGregor NE, Poulton IJ, Pompolo S, Allan EH, Quinn JM, Gillespie MT, Martin TJ, Sims NA
J. Bone Miner. Res., 2008-12-01;23(12):2025-32.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system.
Authors: Gard AL, Gavin E, Solodushko V, Pennica D
Neuroscience, 2004-01-01;127(1):43-52.
Applications: Western Blot -
In vivo electrotransfer of the cardiotrophin-1 gene into skeletal muscle slows down progression of motor neuron degeneration in pmn mice.
Authors: Lesbordes JC, Bordet T, Haase G, Castelnau-Ptakhine L, Rouhani S, Gilgenkrantz H, Kahn A
Hum. Mol. Genet., 2002-07-01;11(14):1615-25.
Applications: ELISA (Standard)
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