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PIT 1

Catalog #: 4168
1 Citation Datasheet / COA / SDS

Discontinued Product

4168 has been discontinued.
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PIT 1 | CAS No. 53501-41-0 | Inositol Lipid Antagonists
1 Image
Description: PIP3 antagonist. Blocks PIP3-PH interaction; inhibits Akt signaling

Chemical Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PIT 1 is a selective PIP3 antagonist. Blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 μM). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo.

Technical Data

M.Wt:
351.76
Formula:
C14H10ClN3O4S
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
53501-41-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.
    Miao et al.
    Proc.Natl.Acad.Sci., 2010;107:2012

Product Datasheets

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Citation for PIT 1

The citations listed below are publications that use Tocris products. Selected citations for PIT 1 include:

1 Citation: Showing 1 - 1

  1. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.
    Authors: Juvekar Et al.
    Proc Natl Acad Sci U S A  2016;113:E4338

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