16,16-Dimethyl Prostaglandin E2

Catalog #: 4027
3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4027/1

16,16-Dimethyl Prostaglandin E2 | CAS No. 39746-25-3 | Prostanoid Receptor Agonists

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Description: Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development

Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid

Purity: ≥95%

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Product Details

Citations (3)

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Biological Activity

16,16-Dimethyl Prostaglandin E2 is a synthetic derivative of prostaglandin E₂ (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.

Technical Data

M.Wt:

380.52

Formula:

C₂₂H₃₆O₅

Solubility:

Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

Purity:

≥95%

Storage:

Store at -80°C

CAS No:

39746-25-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via beta-catenin stabilization.
Jansen S, Holman R, Hedemann I, Frankes E, Elzinga C, Timens W, Gosens R, de Bont E, Schmidt M
J Cell Mol Med, 2015;19(1):210-26.
Prostaglandin E₂ increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells.
Heffner et al.
Mol.Ther, 2018;26:320
Prostaglandin E₂ regulates vertebrate haematopoietic stem cell homeostasis.
North et al.
Nature., 2007;447:1007
Prostaglandin E₂: making more of your marrow.
Lord et al.
Cell Cycle., 2007;6:3054
Genetic interaction of PGE₂ and wnt signaling regulates developmental specification of stem cells and regeneration.
Goessling et al.
Cell., 2009;136:1136

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Citations for 16,16-Dimethyl Prostaglandin E2

The citations listed below are publications that use Tocris products. Selected citations for 16,16-Dimethyl Prostaglandin E2 include:

3 Citations: Showing 1 - 3

COX2 regulates senescence secretome composition and senescence surveillance through PGE2.
Authors: Yoko Et al.
Cell Rep 2021;34:108860
Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength.
Authors: Helen M Et al.
Proc Natl Acad Sci U S A 2017;114:6675-6684
Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
Authors: Jansen Et al.
Oncotarget 2015;19:210

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