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IDE 2

Catalog #: 4016 Datasheet / COA / SDS

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4016 has been discontinued.
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IDE 2 | CAS No. 1136466-93-7 | Compounds for Stem Cell Differentiation
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Description: Induces definitive endoderm formation in mouse and human ESCs

Chemical Name: Heptanedioic acid-1-(2-cyclopentylidenehydrazide)

Purity: ≥98%

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Biological Activity

IDE 2 is a cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). Reported to activate TGF-β signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Promotes pancreatic progenitor cell formation in vitro, and gut tube formation in vivo.

Technical Data

M.Wt:
240.3
Formula:
C12H20N2O3
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1136466-93-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purpose under license from Harvard University.

Background References

  1. Using small molecules to great effect in stem cell differentiation.
    Zaret
    Cell Stem Cell, 2009;4:373
  2. Stimulation of AVNA/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.
    Filby et al.
    Stem Cell Res.Ther., 2011;2:16
  3. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
    Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
    Cell Stem Cell, 2009-04-03;4(4):348-58.

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