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Recombinant Human IL-17A Protein, CF

Catalog #: 317-ILB
92 Citations 4 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
317-ILB-050
Recombinant Human IL-17A Protein Bioactivity
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Product Details
Citations (92)
FAQs
Reviews (4)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human IL-17A Protein, CF Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce CXCL1/GRO alpha secretion in HT‑29 human colon adenocarcinoma cells. The ED50 for this effect is 0.4-4 ng/mL. Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. Yao, Z. et al. (1995) Immunity 3:811. The ED50 for this effect is 1.5-7.5 ng/mL.
Source
E. coli-derived human IL-17/IL-17A protein
Ile20-Ala155, with an N-terminal Met
Accession #
Q16552
N-terminal Sequence
Analysis
Met
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
16 kDa (monomer)

Product Datasheets

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317-ILB

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

317-ILB

Formulation Lyophilized from a 0.2 μm filtered solution in HCl.
Reconstitution Reconstitute at 100 μg/mL in 4 mM HCl.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Human IL-17A Protein Bioactivity View Larger

Recombinant Human IL-17 (Catalog # 317-ILB) induces CXCL1/GRO alpha secretion in HT‑29 human colon adenocarcinoma cells. The ED50 for this effect is 0.4-4 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-17/IL-17A

Interleukin-17A (IL-17A), also known as CTLA-8, is a 15-20 kDa glycosylated cytokine that plays an important role in anti-microbial and chronic inflammation. The six IL-17 cytokines (IL-17A-F) are encoded by separate genes but adopt a conserved cystine knot fold (1, 2). Mature human IL-17A shares 60% amino acid sequence identity with mouse and rat IL-17A (3, 4). IL-17A is secreted by Th17 cells, gamma /δ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells (2). It forms disulfide-linked homodimers as well as disulfide-linked heterodimers with IL-17F (5, 6). IL-17A exerts its effects through the transmembrane IL-17RA in complex with IL-17RC or IL-17RD (7, 8). Both IL-17RA and IL-17RC are required for responsiveness to heterodimeric IL-17A/F (7). IL-17A promotes protective mucosal and epidermal inflammation in response to microbial infection (9‑12). It induces chemokine production, neutrophil influx, and the production of antibacterial peptides (9‑11). IL-17A/F likewise induces neutrophil migration, but IL-17F does not (11). IL-17A additionally enhances the production of inflammatory mediators by rheumatoid synovial fibroblasts and contributes to TNF-alpha induced shock (4, 13). In contrast, it can protect against the progression of colitis by limiting chronic inflammation (12). IL-17A encourages the formation of autoreactive germinal centers and exacerbates the onset and progression of experimental models of autoimmunity (14, 15).
IL-17A has been shown to exert either tumorigenic or anti-tumor effects (16, 17).

References
  1. Gaffen, S.L. (2009) Nat. Rev. Immunol. 9:556.
  2. Cua, D.J. and C.M. Tato (2010) Nat. Rev. Immunol. 10:479.
  3. Yao, Z. et al. (1995) J. Immunol. 155:5483.
  4. Fossiez, F. et al. (1996) J. Exp. Med. 183:2593.
  5. Chang, S.H. and C. Dong (2007) Cell Res. 17:435.
  6. Wright, J.F. et al. (2007) J. Biol. Chem. 282:13447.
  7. Wright, J.F. et al. (2008) J. Immunol. 181:2799.
  8. Rong, Z. et al. (2009) Cell Res. 19:208.
  9. Cho, J.S. et al. (2010) J. Clin. Invest. 120:1762.
  10. Liang, S.C. et al. (2006) J. Exp. Med. 203:2271.
  11. Liang, S.C. et al. (2007) J. Immunol. 179:7791.
  12. O’Connor Jr., W. et al. (2009) Nat. Immunol. 10:603.
  13. Takahashi, N. et al. (2008) J. Exp. Med. 205:1755.
  14. Hsu, H. et al. (2008) Nat. Immunol. 9:166.
  15. Rohn, T.A. et al. (2006) Eur. J. Immunol. 36:2857.
  16. Wang, L. et al. (2009) J. Exp. Med. 206:1457.
  17. Kryczek, I. et al. (2009) Blood 114:357.
Long Name
Interleukin 17
Entrez Gene IDs
3605 (Human); 16171 (Mouse); 301289 (Rat); 449530 (Porcine); 481837 (Canine); 102119976 (Cynomolgus Monkey)
Alternate Names
CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A

Citations for Recombinant Human IL-17A Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

92 Citations: Showing 1 - 10
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  1. The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis
    Authors: Caratis, F;Opie?ka, M;Hausmann, M;Velasco-Estevez, M;Rojek, B;de Vallière, C;Seuwen, K;Rogler, G;Karaszewski, B;Rutkowska, A;
    PloS one
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis
    Authors: Ma, F;Plazyo, O;Billi, AC;Tsoi, LC;Xing, X;Wasikowski, R;Gharaee-Kermani, M;Hile, G;Jiang, Y;Harms, PW;Xing, E;Kirma, J;Xi, J;Hsu, JE;Sarkar, MK;Chung, Y;Di Domizio, J;Gilliet, M;Ward, NL;Maverakis, E;Klechevsky, E;Voorhees, JJ;Elder, JT;Lee, JH;Kahlenberg, JM;Pellegrini, M;Modlin, RL;Gudjonsson, JE;
    Nature communications
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. JAK Signaling Is Critically Important in Cytokine-Induced Viral Susceptibility of Keratinocytes
    Authors: Arnold, KA;Peterson, LF;Beck, LA;Brewer, MG;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury
    Authors: G Xiao, R Kumar, Y Komuro, J Burguet, V Kakarla, I Azizkhania, SA Sheth, CK Williams, XR Zhang, M Macknicki, A Brumm, R Kawaguchi, P Mai, N Kaneko, HV Vinters, ST Carmichael, LA Havton, C DeCarli, JD Hinman
    Cell Reports, 2022-12-20;41(12):111848.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris
    Authors: S Shao, J Chen, WR Swindell, LC Tsoi, X Xing, F Ma, R Uppala, MK Sarkar, O Plazyo, AC Billi, R Wasikowski, KM Smith, P Honore, VE Scott, E Maverakis, JM Kahlenberg, G Wang, NL Ward, PW Harms, JE Gudjonsson
    JCI Insight, 2021-10-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration
    Authors: P Ebner-Peki, L Krisch, M Wolf, S Hochmann, A Hoog, B Vári, K Muigg, R Poupardin, C Scharler, S Schmidhube, E Russe, H Stachelsch, A Schneeberg, K Schallmose, D Strunk
    Theranostics, 2021-07-25;11(17):8430-8447.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. MicroRNA-378a-3p is overexpressed in psoriasis and modulates cell cycle arrest in keratinocytes via targeting BMP2 gene
    Authors: W Soonthornc, P Tangtanata, K Meesilpavi, V Dalm, P Kueanjinda, J Wongpiyabo
    Scientific Reports, 2021-07-09;11(1):14186.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Biomarkers for Comorbidities Modulate the Activity of T-Cells in COPD
    Authors: K Jamal Jame, WJ Gallert, SD Yanik, S Panek, J Kronsbein, D Jungck, A Koch, J Knobloch
    International Journal of Molecular Sciences, 2021-07-02;22(13):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity
    Authors: L Gorchs, S Ahmed, C Mayer, A Knauf, C Fernández, M Svensson, R Heuchel, E Rangelova, P Bergman, H Kaipe
    Sci Rep, 2020-10-15;10(1):17444.
    Species: Human
    Sample Types: Reference Standard
  10. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
    Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
    Cell Rep, 2020-06-30;31(13):107820.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. NADPH oxidase 1 is highly expressed in human large and small bowel cancers
    Authors: J Lu, G Jiang, Y Wu, S Antony, JL Meitzler, A Juhasz, H Liu, K Roy, H Makhlouf, R Chuaqui, D Butcher, MM Konaté, JH Doroshow
    PLoS ONE, 2020-05-19;15(5):e0233208.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins
    Authors: RA Lu, AA Zeki, S Ram-Mohan, N Nguyen, Y Bai, K Chmiel, S Pecic, X Ai, R Krishnan, CC Ghosh
    Front Pharmacol, 2020-05-06;11(0):469.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  13. Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21
    Authors: L Mercurio, D Lulli, F Mascia, E Dellambra, C Scarponi, M Morelli, C Valente, ML Carbone, S Pallotta, G Girolomoni, C Albanesi, S Pastore, S Madonna
    Aging (Albany NY), 2020-04-17;12(8):6823-6851.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  14. Integrated microRNA/mRNA expression profiling of the skin of psoriasis patients
    Authors: D Deli?, K Wolk, R Schmid, O Gabrielyan, D Christou, K Rieber, M Rolser, I Jakob, F Wiech, M Griesser, C Wohnhaas, G Kokolakis, E Witte-Händ, P Baum, R Sabat
    J. Dermatol. Sci., 2019-11-30;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues
    Authors: X Xu, H Fukui, Y Ran, X Wang, Y Inoue, N Ebisudani, H Nishimura, T Tomita, T Oshima, J Watari, H Kiyama, H Miwa
    Mediators Inflamm., 2019-11-06;2019(0):7859460.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress
    Authors: C Merriman, D Fu
    J. Biol. Chem., 2019-10-07;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells
    Authors: Y Wu, MM Konaté, J Lu, H Makhlouf, R Chuaqui, S Antony, JL Meitzler, MJ Difilippan, H Liu, A Juhasz, G Jiang, I Dahan, K Roy, JH Doroshow
    J. Immunol., 2019-09-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models
    Authors: JC Chamcheu, S Esnault, VM Adhami, AL Noll, S Banang-Mbe, T Roy, SS Singh, S Huang, KG Kousoulas, H Mukhtar
    Cells, 2019-09-15;8(9):.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Standard
  19. The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis
    Authors: X Qin, M Liu, S Zhang, C Wang, T Zhang
    Cytokine, 2019-03-01;117(0):84-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment
    Authors: L Mercurio, M Morelli, C Scarponi, EZ Eisenmesse, N Doti, G Pagnanelli, E Gubinelli, C Mazzanti, A Cavani, M Ruvo, CA Dinarello, C Albanesi, S Madonna
    Cell Death Dis, 2018-10-30;9(11):1104.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation
    Authors: M Croes, MC Kruyt, WM Groen, KMA van Dorenm, WJA Dhert, FC Öner, J Alblas
    Sci Rep, 2018-05-08;8(1):7269.
    Species: Rabbit
    Sample Types: Complex Sample Type
    Applications: In Vivo
  22. EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes
    Authors: A Rutkowska, DR Shimshek, AW Sailer, KK Dev
    Neuropharmacology, 2018-01-31;133(0):121-128.
    Species: Human, Mouse, Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  23. BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells
    Authors: M Carretta, AZ Brouwers-V, M Bosman, SJ Horton, JHA Martens, E Vellenga, JJ Schuringa
    PLoS ONE, 2017-12-14;12(12):e0189102.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression
    Authors: Y Wang, JB Mumm, R Herbst, R Kolbeck, Y Wang
    J. Immunol., 2017-09-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Ets Homologous Factor (EHF) has Critical Roles in Epithelial Dysfunction in Airway Disease
    Authors: SL Fossum, MJ Mutolo, A Tugores, S Ghosh, SH Randell, LC Jones, SH Leir, A Harris
    J. Biol. Chem., 2017-05-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes
    Authors: KA Cho, M Park, YH Kim, SY Woo
    Biochem. Biophys. Res. Commun., 2017-04-27;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Interferon-? induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps
    Authors: BF Wang, PP Cao, ZC Wang, ZY Li, ZZ Wang, J Ma, B Liao, YK Deng, XB Long, K Xu, H Wang, H Wang, M Zeng, X Lu, Z Liu
    Allergy, 2017-04-04;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36?
    Authors: JS Ainscough, T Macleod, D McGonagle, R Brakefield, JM Baron, A Alase, M Wittmann, M Stacey
    Proc. Natl. Acad. Sci. U.S.A, 2017-03-13;114(13):E2748-E2757.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis
    Authors: Dobrina N Hull
    Arthritis Res. Ther, 2016-12-23;18(1):303.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA (Standard)
  30. Interleukin-17A-Induced Epithelial-Mesenchymal Transition of Human Intrahepatic Biliary Epithelial Cells: Implications for Primary Biliary Cirrhosis
    Authors: Qingshui Huang
    Tohoku J. Exp. Med, 2016-12-01;240(4):269-275.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells
    Sci Rep, 2016-11-09;6(0):36795.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. A Novel PEGylation Method for Improving the Pharmacokinetic Properties of Anti-Interleukin-17A RNA Aptamers
    Authors: Hiroaki Yamazaki
    Nucleic Acid Ther, 2016-11-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations
    Authors: Robert Sabat
    Mediators Inflamm., 2016-10-23;2016(0):4097574.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
    Sci Rep, 2016-05-17;6(0):26071.
    Species: Complex Species Category
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development (Detection)
  35. Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1
    Authors: TM Garcia-Bat, E Kim, F Concha-Ben, S Trivedi, RB Mailliard, A Gambotto, RL Ferris
    J. Immunol, 2016-02-05;196(6):2870-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
    Authors: Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, Ikinciogullari A, Dogu F, Belkadi A, Levy R, Migaud M, Boisson B, Bolze A, Itan Y, Goudin N, Cottineau J, Picard C, Abel L, Bustamante J, Casanova J, Puel A
    J Exp Med, 2015-04-27;212(5):619-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
    Authors: Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C
    Respir Res, 2015-02-07;16(0):14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. The expression and regulation of chemerin in the epidermis.
    Authors: Banas M, Zegar A, Kwitniewski M, Zabieglo K, Marczynska J, Kapinska-Mrowiecka M, LaJevic M, Zabel B, Cichy J
    PLoS ONE, 2015-02-06;10(2):e0117830.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells.
    Authors: Adams, Kelly M, Abraham, Valsamma, Spielman, Daniel, Kolls, Jay K, Rubenstein, Ronald C, Conner, Gregory, Cohen, Noam A, Kreindler, James L
    PLoS ONE, 2014-08-20;9(8):e103263.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling.
    Authors: Wu L, Wang C, Boisson B, Misra S, Rayman P, Finke J, Puel A, Casanova J, Li X
    J Immunol, 2014-07-14;193(4):1590-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M.
    Authors: Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F
    PLoS ONE, 2014-07-10;9(7):e101937.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Interleukin 17A promotes gastric cancer invasiveness via NF-kappaB mediated matrix metalloproteinases 2 and 9 expression.
    Authors: Wang Y, Wu H, Wu X, Bian Z, Gao Q
    PLoS ONE, 2014-06-06;9(6):e96678.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Interleukin-17A promotes MUC5AC expression and goblet cell hyperplasia in nasal polyps via the Act1-mediated pathway.
    Authors: Xia, Wentong, Bai, Jing, Wu, Xingmei, Wei, Yi, Feng, Shaoyan, Li, Lei, Zhang, Jia, Xiong, Guanxia, Fan, Yunping, Shi, Jianbo, Li, Huabin
    PLoS ONE, 2014-06-03;9(6):e98915.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair.
    Authors: MacLeod A, Rudolph R, Corriden R, Ye I, Garijo O, Havran W
    J Immunol, 2014-05-07;192(12):5695-702.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  45. Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.
    Authors: Ardeljan, Daniel, Wang, Yujuan, Park, Stanley, Shen, Defen, Chu, Xi Kathy, Yu, Cheng-Ro, Abu-Asab, Mones, Tuo, Jingshen, Eberhart, Charles, Olsen, Timothy, Mullins, Robert F, White, Gary, Wadsworth, Sam, Scaria, Abraham, Chan, Chi-Chao
    PLoS ONE, 2014-04-29;9(4):e95900.
    Species: Human, Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Whole Cells
    Applications: Bioassay
  46. IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model.
    Authors: Chiricozzi, Andrea, Nograles, Kristine, Johnson-Huang, Leanne M, Fuentes-Duculan, Judilyn, Cardinale, Irma, Bonifacio, Kathleen, Gulati, Nicholas, Mitsui, Hiroshi, Guttman-Yassky, Emma, Suarez-Farinas, Mayte, Krueger, James G
    PLoS ONE, 2014-02-28;9(2):e90284.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  47. Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement.
    Authors: Truchetet M, Brembilla N, Montanari E, Lonati P, Raschi E, Zeni S, Fontao L, Meroni P, Chizzolini C
    Arthritis Rheum, 2013-05-01;65(5):1347-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis.
    Authors: Chen Z, Kim S, Chamberlain N, Pickens S, Volin M, Volkov S, Arami S, Christman J, Prabhakar B, Swedler W, Mehta A, Sweiss N, Shahrara S
    J Immunol, 2013-04-19;190(10):5256-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.
    Authors: Zizzo G, Cohen P
    J Immunol, 2013-04-17;190(10):5237-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis.
    Authors: Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S
    J Immunol, 2013-03-18;190(8):3959-66.
    Species: Human
    Sample Types: Plasma
    Applications: Bioassay
  51. Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.
    Authors: Johnston A, Xing X, Swindell W, Kochkodan J, Riblett M, Nair R, Stuart P, Ding J, Voorhees J, Elder J, Gudjonsson J
    Hum Mol Genet, 2013-01-31;22(9):1807-15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis.
    Authors: Gordon K, Kochkodan J, Blatt H, Lin S, Kaplan N, Johnston A, Swindell W, Hoover P, Schlosser B, Elder J, Gudjonsson J, Getsios S
    J Invest Dermatol, 2012-11-29;133(3):712-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
    Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
    PLoS Biol, 2012-09-25;10(9):e1001395.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012-07-26;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
    Authors: Ramirez-Carrozzi V, Sambandam A, Luis E
    Nat. Immunol., 2011-10-12;12(12):1159-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. IL-17A and TNF-alpha Exert Synergistic Effects on Expression of CXCL5 by Alveolar Type II Cells In Vivo and In Vitro.
    Authors: Liu Y, Mei J, Gonzales L, Yang G, Dai N, Wang P, Zhang P, Favara M, Malcolm KC, Guttentag S, Worthen GS
    J. Immunol., 2011-01-31;186(5):3197-205.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression.
    Authors: Johnston A, Xing X, Guzman AM, Riblett M, Loyd CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Kang S, Voorhees JJ, Elder JT, Gudjonsson JE
    J. Immunol., 2011-01-17;186(4):2613-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Evidence for altered Wnt signaling in psoriatic skin.
    Authors: Gudjonsson JE, Johnston A, Stoll SW
    J. Invest. Dermatol., 2010-04-08;130(7):1849-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes.
    Authors: Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Immunol., 2010-03-31;184(9):4880-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis.
    Authors: Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F
    J. Immunol., 2010-03-24;184(0):5263-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines.
    Authors: Kisand K, Boe Wolff AS, Podkrajsek KT, Tserel L, Link M, Kisand KV, Ersvaer E, Perheentupa J, Erichsen MM, Bratanic N, Meloni A, Cetani F, Perniola R, Ergun-Longmire B, Maclaren N, Krohn KJ, Pura M, Schalke B, Strobel P, Leite MI, Battelino T, Husebye ES, Peterson P, Willcox N, Meager A
    J. Exp. Med., 2010-02-01;207(2):299-308.
    Species: Human
    Sample Types: Serum
    Applications: ELISA (Capture)
  62. Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.
    Authors: Nishida A, Andoh A, Imaeda H, Inatomi O, Shiomi H, Fujiyama Y
    Gut, 2009-12-08;59(4):531-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis.
    Authors: Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R
    Eur. J. Immunol., 2009-12-01;39(12):3570-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells.
    Authors: Xu G, Zhang L, Wang DY, Xu R, Liu Z, Han DM, Wang XD, Zuo KJ, Li HB
    Allergy, 2009-11-25;65(5):581-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients.
    Authors: Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK
    Immunol. Lett., 2009-11-04;127(2):150-6.
    Applications: ELISA (Standard)
  66. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema.
    Authors: Shan M, Cheng HF, Song LZ
    Sci Transl Med, 2009-10-28;1(4):4ra10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression.
    Authors: Tohyama M, Hanakawa Y, Shirakata Y, Dai X, Yang L, Hirakawa S, Tokumaru S, Okazaki H, Sayama K, Hashimoto K
    Eur. J. Immunol., 2009-10-01;39(10):2779-88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages.
    Authors: Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, Ponsoda S, Delneste Y, Hebbar M, Jeannin P
    Int. J. Cancer, 2009-07-15;125(2):367-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Interleukin-32 expression in the pancreas.
    Authors: Nishida A, Andoh A, Inatomi O, Fujiyama Y
    J. Biol. Chem., 2009-04-21;284(26):17868-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. IL-17 induces monocyte migration in rheumatoid arthritis.
    Authors: Shahrara S, Pickens SR, Dorfleutner A, Pope RM
    J. Immunol., 2009-03-15;182(6):3884-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
    Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
    Bone, 2009-03-02;44(6):1143-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
    Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
    Circulation, 2009-03-02;119(10):1424-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes.
    Authors: Zrioual S, Ecochard R, Tournadre A, Lenief V, Cazalis MA, Miossec P
    J. Immunol., 2009-03-01;182(0):3112-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.
    Authors: Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H
    J. Allergy Clin. Immunol., 2008-12-03;123(1):179-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
    Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.
    Authors: Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J
    Arthritis Rheum., 2008-12-01;58(12):3820-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis.
    Authors: Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, Zaba LC, Cardinale I, Nograles KE, Khatcherian A, Novitskaya I, Carucci JA, Bergman R, Krueger JG
    J. Immunol., 2008-11-15;181(10):7420-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils.
    Authors: Rahmoun M, Moles JP, Pedretti N, Mathieu M, Fremaux I, Raison-Peyron N, Lecron JC, Yssel H, Pene J
    J. Invest. Dermatol., 2008-10-09;129(3):671-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis.
    Authors: Watanabe H, Kawaguchi M, Fujishima S, Ogura M, Matsukura S, Takeuchi H, Ohba M, Sueki H, Kokubu F, Hizawa N, Adachi M, Huang SK, Iijima M
    J. Invest. Dermatol., 2008-10-02;129(3):650-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities.
    Authors: Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, Anders PM, Tocker JE, Comeau MR, Budelsky AL
    J. Immunol., 2008-09-15;181(6):4299-310.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex.
    Authors: Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, Tomkinson KN, Fitz LJ, Wolfman NM, Collins M, Dunussi-Joannopoulos K, Chatterjee-Kishore M, Carreno BM
    J. Immunol., 2008-08-15;181(4):2799-805.
    Species: Human
    Sample Types: Recombinant Protein, Whole Cells
    Applications: Bioassay, Surface Plasmon Resonance
  82. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
    Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
    J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.
    Authors: Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK
    Nat. Med., 2008-02-10;14(3):275-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood.
    Authors: Zrioual S, Toh ML, Tournadre A, Zhou Y, Cazalis MA, Pachot A, Miossec V, Miossec P
    J. Immunol., 2008-01-01;180(1):655-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Ultrasensitive flow-based immunoassays using single-molecule counting.
    Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
    Clin. Chem., 2007-09-21;53(11):1990-5.
    Applications: ELISA (Standard)
  86. Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease.
    Authors: Shioya M, Nishida A, Yagi Y, Ogawa A, Tsujikawa T, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y, Andoh A
    Clin. Exp. Immunol., 2007-06-22;149(3):480-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
    Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
    J. Immunol., 2007-05-01;178(9):5973-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.
    Authors: Brechter AB, Lerner UH
    Arthritis Rheum., 2007-03-01;56(3):910-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum.
    Authors: Witowski J, Ksiazek K, Warnecke C, Kuzlan M, Korybalska K, Tayama H, Wisniewska-Elnur J, Pawlaczyk K, Trominska J, Breborowicz A, Jorres A
    Kidney Int., 2007-01-17;71(6):514-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils.
    Authors: Filer A, Parsonage G, Smith E, Osborne C, Thomas AM, Curnow SJ, Rainger GE, Raza K, Nash GB, Lord J, Salmon M, Buckley CD
    Arthritis Rheum., 2006-07-01;54(7):2096-108.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.
    Authors: Vaknin-Dembinsky A, Balashov K, Weiner HL
    J. Immunol., 2006-06-15;176(12):7768-74.
    Applications: ELISA (Specificity Testing)
  92. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
    Authors: Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H
    J. Immunol., 2005-11-01;175(9):6177-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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