Recombinant Human TGF-alpha Protein, CF Summary
Product Specifications
Val40-Ala89
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
239-A
Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA. |
Reconstitution | Reconstitute at 100 μg/mL in sterile 10 mM Acetic Acid. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Reconstitution Calculator
Background: TGF-alpha
TGF-alpha was originally isolated from the conditioned media of oncogenically transformed cells as an EGF-like bioactivity. TGF-alpha is a member of the EGF family of cytokines that are synthesized as transmembrane precursors and are characterized by the presence of one or several EGF structural units in their extracellular domain. The soluble forms of these cytokines are released from the transmembrane protein by proteolytic cleavage. Membrane-bound proTGF-alpha is biologically active and seems to play a role in mediation of cell-cell adhesion and in juxtacrine stimulation of adjacent cells. Expression of TGF-alpha is widespread in tumors and transformed cells. TGF-alpha is also expressed in normal tissues during embryogenesis and in adult tissues, including pituitary, brain, keratinocytes and macrophages. Mature TGF-alpha shows approximately 93% amino acid sequence identity with mouse or rat TGF-alpha and is not species specific in its biological effects.
TGF-alpha binds to the EGF receptor and activates the receptor tyrosine kinase. Accordingly, TGF-alpha shows a similar potency to EGF as a mitogen for fibroblasts and as an inducer of epithelial development in vivo. TGF-alpha is reportedly more potent than EGF as an angiogenic factor in vivo and as a stimulator for keratinocyte migration. The EGF receptor gene represents the cellular homologue of the avian v-erb-B oncogene.
Citations for Recombinant Human TGF-alpha Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand binding
Authors: Wirth, D;Özdemir, E;Hristova, K;
Nature communications
Species: Chinese Hamster
Sample Types: Vesicles
Applications: Bioassay -
EGF, TGF-? and Amphiregulin Differently Regulate Endometrium-Derived Mesenchymal Stromal/Stem Cells
Authors: Kamentseva, RS;Kharchenko, MV;Gabdrahmanova, GV;Kotov, MA;Kosheverova, VV;Kornilova, ES;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ErbBs in Lens Cell Fibrosis and Secondary Cataract
Authors: VanSlyke, JK;Boswell, BA;Musil, LS;
Investigative ophthalmology & visual science
Species: Avian - Chicken
Sample Types: Whole Tissue
Applications: Bioassay -
Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis
Authors: Takada, H;Sasagawa, Y;Yoshimura, M;Tanaka, K;Iwayama, Y;Hayashi, T;Isomura-Matoba, A;Nikaido, I;Kurisaki, A;
Nature communications
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Reversal of liver failure using a bioartificial liver device implanted with clinical-grade human-induced hepatocytes
Authors: Y Wang, Q Zheng, Z Sun, C Wang, J Cen, X Zhang, Y Jin, B Wu, T Yan, Z Wang, Q Gu, X Lv, J Nan, Z Wu, W Sun, G Pan, L Zhang, L Hui, X Cai
Cell Stem Cell, 2023-04-13;0(0):.
Species: Human
Sample Types:
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Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
Authors: JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson
Cell Reports, 2022-12-06;41(10):111775.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ADAM17-mediated EGFR ligand shedding directs macrophage promoted cancer cell invasion
Authors: S Gnosa, L Puig-Blasc, KB Piotrowski, ML Freiberg, S Savickas, DH Madsen, U Auf dem Ke, P Kronqvist, M Kveiborg
JCI Insight, 2022-09-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation -
Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism
Authors: C Monteiro, L Miarka, M Perea-Garc, N Priego, P García-Góm, L Álvaro-Esp, A de Pablos-, N Yebra, D Retana, P Baena, C Fustero-To, O Graña-Cast, K Troulé, E Caleiras, P Tezanos, P Muela, E Cintado, JL Trejo, JM Sepúlveda, P González-L, L Jiménez-Ro, LM Moreno, O Esteban, Á Pérez-Núñe, A Hernández-, J Mazarico G, I Ferrer, R Suárez, EM Garrido-Ma, L Paz-Ares, C Dalmasso, E Cohen-Jona, A Siegfried, A Hegarty, S Keelan, D Varešlija, LS Young, M Mohme, Y Goy, H Wikman, J Fernández-, G Blasco, L Alcázar, C Cabañuz, SI Grivenniko, A Ianus, N Shemesh, CC Faria, R Lee, P Lorigan, E Le Rhun, M Weller, R Soffietti, L Bertero, U Ricardi, J Bosch-Barr, E Sais, E Teixidor, A Hernández-, A Calvo, J Aristu, SM Martin, A Gonzalez, O Adler, N Erez, RENACER, M Valiente
Nature Medicine, 2022-04-11;28(4):752-765.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias
Authors: C Hu, CA Leche, A Kiyatkin, Z Yu, SE Stayrook, KM Ferguson, MA Lemmon
Nature, 2022-02-09;602(7897):518-522.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer
Authors: S Steiner, GM Seleznik, T Reding, M Stopic, D Lenggenhag, E Ten Buren, D Eshmuminov, K Endhardt, C Hagedorn, AM Heidenblut, A Bratus-Neu, J Grossmann, C Trachsel, KS Jabbar, SA Hahn, JV Berg, R Graf, A Gupta
Oncogene, 2022-01-26;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
SERMs (selective estrogen receptor modulator), acting as estrogen receptor beta agonists in hepatocellular carcinoma cells, inhibit the transforming growth factor-alpha-induced migration via specific inhibition of AKT signaling pathway
Authors: R Matsushima, N Yamada, Y Hattori, Y Hosokawa, J Tachi, T Hori, O Kozawa
PLoS ONE, 2022-01-10;17(1):e0262485.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional
Authors: IT Stancil, JE Michalski, D Davis-Hall, HW Chu, JA Park, CM Magin, IV Yang, BJ Smith, E Dobrinskik, DA Schwartz
Nature Communications, 2021-07-27;12(1):4566.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cardiac macrophages prevent sudden death during heart stress
Authors: J Sugita, K Fujiu, Y Nakayama, T Matsubara, J Matsuda, T Oshima, Y Liu, Y Maru, E Hasumi, T Kojima, H Seno, K Asano, A Ishijima, N Tomii, M Yamazaki, F Kudo, I Sakuma, R Nagai, I Manabe, I Komuro
Nature Communications, 2021-03-26;12(1):1910.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs
Authors: K Nomi, R Hayashi, Y Ishikawa, Y Kobayashi, T Katayama, AJ Quantock, K Nishida
Cell Reports, 2021-02-02;34(5):108715.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells
Authors: S Feng, J Wu, WL Qiu, L Yang, X Deng, Y Zhou, Y Chen, X Li, L Yu, H Li, ZR Xu, Y Xiao, X Ren, L Zhang, C Wang, Z Sun, J Wang, X Ding, Y Chen, P Gadue, G Pan, M Ogawa, S Ogawa, J Na, P Zhang, L Hui, H Yin, L Chen, CR Xu, X Cheng
Cell Reports, 2020-12-08;33(10):108455.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Heat shock protein 70 positively regulates transforming growth factor-&alpha-induced hepatocellular carcinoma cell migration via the AKT signaling pathway
Authors: K Kobayashi, R Matsushima, N Yamada, S Migita, T Hioki, D Mizutani, O Kozawa
Heliyon, 2020-09-23;6(9):e05002.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy
Authors: S Liu, Y Wang, Y Han, W Xia, L Zhang, S Xu, H Ju, X Zhang, G Ren, L Liu, W Ye, Z Zhang, J Hu
Theranostics, 2020-08-25;10(23):10589-10605.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Quercetin suppresses the migration of hepatocellular carcinoma cells stimulated by hepatocyte growth factor or transforming growth factor-&alpha: Attenuation of AKT signaling pathway
Authors: N Yamada, R Matsushima, O Kozawa
Arch. Biochem. Biophys., 2020-02-04;682(0):108296.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking
Authors: L Yammine, A Zablocki, W Baron, F Terzi, M Gallazzini
Cell Rep, 2019-11-12;29(7):2067-2077.e6.
Species: Human
Sample Types: Whole Cell
Applications: Cell Culture -
Production of piglets from in�vitro-produced blastocysts by ultrasound-guided ovum pick-up from live donors
Authors: K Yoshioka, K Uchikura, T Suda, S Matoba
Theriogenology, 2019-09-12;141(0):113-119.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay -
Activating a Reserve Neural Stem Cell Population In�Vitro Enables Engraftment and Multipotency after Transplantation
Authors: J Peterson, B Lin, CM Barrios-Ca, DB Herrick, EH Holbrook, W Jang, JH Coleman, JE Schwob
Stem Cell Reports, 2019-03-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation -
Blockage of TGF-? Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells
Authors: Y Li, H Li, Y Duan, X Cai, D You, F Zhou, C Yang, X Tuo, Z Liu
Biomed Res Int, 2019-02-18;2019(0):8231267.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
Authors: N Priego, L Zhu, C Monteiro, M Mulders, D Wasilewski, W Bindeman, L Doglio, L Martínez, E Martínez-S, SRY Cajal, D Megías, E Hernández-, C Blanco-Apa, L Martínez, E Zarzuela, J Muñoz, C Fustero-To, E Pineiro, A Hernández-, L Bertero, V Poli, M Sánchez-Ma, JA Menendez, R Soffietti, J Bosch-Barr, M Valiente
Nat. Med., 2018-06-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Epiregulin and EGFR interactions are involved in pain processing
Authors: LJ Martin, SB Smith, A Khoutorsky, CA Magnussen, A Samoshkin, RE Sorge, C Cho, N Yosefpour, S Sivaselvac, S Tohyama, T Cole, TM Khuong, E Mir, DG Gibson, JS Wieskopf, SG Sotocinal, JS Austin, CB Meloto, JH Gitt, C Gkogkas, N Sonenberg, JD Greenspan, RB Fillingim, R Ohrbach, GD Slade, C Knott, R Dubner, AG Nackley, A Ribeiro-da, GG Neely, W Maixner, DV Zaykin, JS Mogil, L Diatchenko
J. Clin. Invest., 2017-08-07;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNF?-TGF?-EGFR
Authors: TS Lau, LK Chan, EC Wong, CW Hui, K Sneddon, TH Cheung, SF Yim, JH Lee, CS Yeung, TK Chung, J Kwong
Oncogene, 2017-02-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation
Proc. Natl. Acad. Sci. U.S.A., 2016-11-28;113(50):14360-14365.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Phosphorylated Heat Shock Protein 20 (HSPB6) Regulates Transforming Growth Factor-?-Induced Migration and Invasion of Hepatocellular Carcinoma Cells
Authors: R Matsushima, H Toyoda, T Nagasawa, E Yasuda, N Chiba, S Okuda, A Maeda, Y Kaneoka, T Kumada, O Kozawa
PLoS ONE, 2016-04-05;11(4):e0151907.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1
Cytokine, 2015-12-31;82(0):58-69.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
RAF inhibitors that evade paradoxical MAPK pathway activation.
Authors: Zhang C, Spevak W, Zhang Y, Burton E, Ma Y, Habets G, Zhang J, Lin J, Ewing T, Matusow B, Tsang G, Marimuthu A, Cho H, Wu G, Wang W, Fong D, Nguyen H, Shi S, Womack P, Nespi M, Shellooe R, Carias H, Powell B, Light E, Sanftner L, Walters J, Tsai J, West B, Visor G, Rezaei H, Lin P, Nolop K, Ibrahim P, Hirth P, Bollag G
Nature, 2015-10-14;526(7574):583-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences.
Authors: Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, Bertelsen V, Sitek J, Hol J, Haraldsen G, Khnykin D
J Invest Dermatol, 2015-03-04;135(7):1771-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Temporal expression of growth factors triggered by epiregulin regulates inflammation development.
Authors: Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, Atsumi T, Meng J, Bando H, Singh R, Sabharwal L, Jiang J, Kumai N, Miyasaka N, Sakoda S, Yamauchi-Takihara K, Ogura H, Hirano T, Murakami M
J Immunol, 2015-01-02;194(3):1039-46.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A comprehensive transcriptional portrait of human cancer cell lines.
Authors: Klijn C, Durinck S, Stawiski E, Haverty P, Jiang Z, Liu H, Degenhardt J, Mayba O, Gnad F, Liu J, Pau G, Reeder J, Cao Y, Mukhyala K, Selvaraj S, Yu M, Zynda G, Brauer M, Wu T, Gentleman R, Manning G, Yauch R, Bourgon R, Stokoe D, Modrusan Z, Neve R, de Sauvage F, Settleman J, Seshagiri S, Zhang Z
Nat Biotechnol, 2014-12-08;33(3):306-12.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Signaling by the extracellular matrix protein Reelin promotes granulosa cell proliferation in the chicken follicle.
Authors: Eresheim, Christin, Leeb, Christia, Buchegger, Patricia, Nimpf, Johannes
J Biol Chem, 2014-02-26;289(14):10182-91.
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay -
Alveolar progenitor and stem cells in lung development, renewal and cancer.
Authors: Desai, Tushar J, Brownfield, Douglas, Krasnow, Mark A
Nature, 2014-02-05;507(7491):190-4.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
Authors: Huang, Sarah X, Islam, Mohammad, O'Neill, John, Hu, Zheng, Yang, Yong-Gua, Chen, Ya-Wen, Mumau, Melanie, Green, Michael, Vunjak-Novakovic, Gordana, Bhattacharya, Jahar, Snoeck, Hans-Wil
Nat Biotechnol, 2013-12-01;32(1):84-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation.
Authors: Meijer I, Kerperien J, Sotoca A, van Zoelen E, van Leeuwen J
Cell Signal, 2013-01-17;25(4):919-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells.
Authors: Kim S, Lewis C, Nadel JA
Exp. Cell Res., 2011-09-07;317(18):2650-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
Authors: Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M
Stem Cells, 2011-06-01;29(6):964-71.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells.
Authors: Kim S, Lewis C, Nadel JA
J. Immunol., 2011-02-07;186(6):3392-400.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress.
Authors: Park JA, Drazen JM, Tschumperlin DJ
J. Biol. Chem., 2010-07-22;285(39):29817-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Evidence for altered Wnt signaling in psoriatic skin.
Authors: Gudjonsson JE, Johnston A, Stoll SW
J. Invest. Dermatol., 2010-04-08;130(7):1849-59.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ependymal stem cells divide asymmetrically and transfer progeny into the subventricular zone when activated by injury.
Authors: Gleason D, Fallon JH, Guerra M, Liu JC, Bryant PJ
Neuroscience, 2008-07-11;156(1):81-8.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo -
Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model.
Authors: Sasaki T, Nakamura T, Rebhun RB, Cheng H, Hale KS, Tsan RZ, Fidler IJ, Langley RR
Am. J. Pathol., 2008-07-01;173(1):205-16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Development and validation of sandwich ELISA microarrays with minimal assay interference.
Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
J. Proteome Res., 2008-04-19;7(6):2406-14.
Applications: ELISA (Standard) -
Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine.
Authors: Garcia B, Neninger E, de la Torre A, Leonard I, Martinez R, Viada C, Gonzalez G, Mazorra Z, Lage A, Crombet T
Clin. Cancer Res., 2008-02-01;14(3):840-6.
Species: Human
Sample Types: Serum
Applications: ELISA Developmet -
EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases.
Authors: Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L
J. Biol. Chem., 2007-07-17;282(37):26656-64.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells.
Authors: Wolff GS, Chiang PJ, Smith SM, Romero R, Armant DR
Biol. Reprod., 2007-03-28;77(1):53-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.
Authors: Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons DM, Newton RC, Fridman JS, Minna JD, Scherle PA
Cancer Cell, 2006-07-01;10(1):39-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.
Authors: Li Y, Fan J, Chen M, Li W, Woodley DT
J. Invest. Dermatol., 2006-05-11;126(9):2096-105.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines.
Authors: Rhodes KE, Raivich G, Fawcett JW
Neuroscience, 2006-04-21;140(1):87-100.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo -
Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli.
Authors: Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC
Am. J. Respir. Cell Mol. Biol., 2006-03-16;35(2):165-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor.
Authors: Armant DR, Kilburn BA, Petkova A, Edwin SS, Duniec-Dmuchowski ZM, Edwards HJ, Romero R, Leach RE
Development, 2006-01-11;133(4):751-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.
Authors: Beer HD, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, Werner S
Oncogene, 2005-08-11;24(34):5269-77.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Novel regulators of kidney development from the tips of the ureteric bud.
Authors: Schmidt-Ott KM, Yang J, Chen X, Wang H, Paragas N, Mori K, Li JY, Lu B, Costantini F, Schiffer M, Bottinger E, Barasch J
J. Am. Soc. Nephrol., 2005-05-25;16(7):1993-2002.
Species: Rat
Sample Types: Whole Tissue
Applications: Bioassay -
Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
J. Cell. Physiol., 2005-04-01;203(1):35-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Central administration of transforming growth factor-alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters.
Authors: Snodgrass-Belt P, Gilbert JL, Davis FC
Brain Res., 2005-03-21;1038(2):171-82.
Species: Hamster
Sample Types: In Vivo
Applications: In Vivo -
Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype.
Authors: Leach RE, Kilburn B, Wang J, Liu Z, Romero R, Armant DR
Dev. Biol., 2004-02-15;266(2):223-37.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
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