Home / TGF-beta Receptor Inhibitors / SB 431542

SB 431542

Catalog #: 1614
263 Citations 4 Reviews Datasheet / COA / SDS
GMP Version Available: TB1614-GMP
GMP
Catalog # Availability Size / Price Qty
1614/10
1614/1
1614/50
SB 431542 | CAS No. 301836-41-9 | TGF-beta Receptor Inhibitors
2 Images
Description: Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

Purity: ≥99%

Product Details
Citations (263)
Supplemental Products
Reviews (4)
Biological Activity Scientific Data Technical Data Background Product Datasheets Calculators

Biological Activity

SB 431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines. Also used in a protocol to generate brain organoids from human iPSCs.

SB 431542 synthesized to cGMP guidelines also available.

For more information about how SB 431542 may be used, see our protocols: 3D Culture of Lung Alveolar Cells, Differentiation of Hematopoietic Progenitors from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Generating Vascular Organoids, Accelerated Induction of Cortical Neurons from hiPSCs.

Scientific Data

N/A dopaminergic neurons derived from hiPSCs using SB 431542 View Larger

Application of SB 431542 in dopaminergic neurons derived from hiPSCs. Dopaminergic neurons derived from human induced pluripotent stem cells (hiPSC) using SB 431542, CHIR 99021 (Catalog # 4423, Tocris), DAPT (Catalog # 2634, Tocris) and Purmorphamine (Catalog # 4551, Tocris). Cells cultured in Neuronal Media supplemented with TGF-3 (Catalog # 8420-B3, R&D Systems), cAMP, GDNF (Catalog # 212-GD, R&D Systems), BDNF (Catalog # 248-BDB, R&D Systems), N21-MAX (Catalog # AR008, R&D Systems). Differentiation shown at days 55 (left) and 62 (right). Images courtesy of Kevin Flynn, Bio-Techne.

Technical Data

M.Wt:
384.39
Formula:
C22H16N4O3
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
301836-41-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Differential regulation of CD103 (�E integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands
    MM Roe, S Swain, TA Sebrell, MA Sewell, MM Collins, BA Perrino, PD Smith, LE Smythies, D Bimczok
    J. Leukoc. Biol, 2017;0(0):.
  2. Dual small-molecule targeting of SMAD signaling stimulates human induced pluripotent stem cells toward neural lineages.
    Wattanapanitch M, Klincumhom N, Potirat P, Amornpisutt R, Lorthongpanich C, U-pratya Y, Laowtammathron C, Kheolamai P, Poungvarin N, Issaragrisil S
    PLoS ONE, 2014;9(9):e106952.
  3. Biglycan and decorin differentially regulate signaling in the fetal membranes.
    Wu Z, Horgan C, Carr O, Owens R, Iozzo R, Lechner B
    Matrix Biol, 2014;35(0):266-75.
  4. Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes
    C Lang, KR Campbell, BJ Ryan, P Carling, M Attar, J Vowles, OV Perestenko, R Bowden, F Baig, M Kasten, MT Hu, SA Cowley, C Webber, R Wade-Marti
    Cell Stem Cell, 2018;0(0):.
  5. Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis

    PLoS ONE, 2016;11(9):e0162300.
  6. Reliability of human cortical organoid generation
    SJ Yoon, LS Elahi, AM Pa?ca, RM Marton, A Gordon, O Revah, Y Miura, EM Walczak, GM Holdgate, HC Fan, JR Huguenard, DH Geschwind, SP Pa?ca
    Nat. Methods, 2019;16(1):75-78.
  7. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling
    KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton
    Cell Stem Cell, 2017;0(0):.
  8. Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts.
    Li S, Meyer N, Quarto N, Longaker M
    PLoS ONE, 2013;8(3):e58610.
  9. TGF beta1-Induced Baf60c Regulates both Smooth Muscle Cell Commitment and Quiescence.
    Sohni A, Mulas F, Ferrazzi F, Luttun A, Bellazzi R, Huylebroeck D, Ekker S, Verfaillie C
    PLoS ONE, 2012;7(10):e47629.
  10. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta.
    Wiener Z, Band A, Kallio P, Hogstrom J, Hyvonen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K
    Proc Natl Acad Sci U S A, 2014;111(21):E2229-36.
  11. A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells
    JC Niclis, CW Gantner, CPJ Hunt, JA Kauhausen, JC Durnall, JM Haynes, CW Pouton, CL Parish, LH Thompson
    Stem Cell Reports, 2017;0(0):.
  12. Tissue-engineered vascular grafts created from human induced pluripotent stem cells.
    Sundaram S, One J, Siewert J, Teodosescu S, Zhao L, Dimitrievska S, Qian H, Huang A, Niklason L
    Stem Cells Transl Med, 2014;3(12):1535-43.
  13. Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells
    F Hawkins, P Kramer, A Jacob, I Driver, DC Thomas, KB McCauley, N Skvir, AM Crane, AA Kurmann, AN Hollenberg, S Nguyen, BG Wong, AS Khalil, SX Huang, S Guttentag, JR Rock, JM Shannon, BR Davis, DN Kotton
    J. Clin. Invest., 2017;127(6):2277-2294.
  14. Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci
    MP Forrest, H Zhang, W Moy, H McGowan, C Leites, LE Dionisio, Z Xu, J Shi, AR Sanders, WJ Greenleaf, CA Cowan, ZP Pang, PV Gejman, P Penzes, J Duan
    Cell Stem Cell, 2017;0(0):.
  15. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
    Tabata T, Petitt M, Zydek M, Fang-Hoover J, Larocque N, Tsuge M, Gormley M, Kauvar L, Pereira L
    J Virol, 2015;89(9):5134-47.
  16. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
    Wrighton, Paul J, Klim, Joseph R, Hernandez, Brandon, Koonce, Chad H, Kamp, Timothy, Kiessling, Laura L
    Proc Natl Acad Sci U S A, 2014;111(51):18126-31.
  17. IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics
    S O'Reilly, M Ciechomska, N Fullard, S Przyborski, JM van Laar
    Sci Rep, 2016;6(0):25066.
  18. miR-373 is regulated by TGFbeta signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells.
    Rosa A, Papaioannou M, Krzyspiak J, Brivanlou A
    Dev Biol, 2014;391(1):81-8.
  19. Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.
    Orlova, Valeria, van den Hil, Francijn, Petrus-Reurer, Sandra, Drabsch, Yvette, Ten Dijke, Peter, Mummery, Christin
    Nat Protoc, 2014;9(6):1514-31.
  20. Dynamic behaviour of human neuroepithelial cells in the developing forebrain
    L Subramania, M Bershteyn, MF Paredes, AR Kriegstein
    Nat Commun, 2017;8(0):14167.
  21. MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling
    N Mellios, DA Feldman, SD Sheridan, JPK Ip, S Kwok, SK Amoah, B Rosen, BA Rodriguez, B Crawford, R Swaminatha, S Chou, Y Li, M Ziats, C Ernst, R Jaenisch, SJ Haggarty, M Sur
    Mol. Psychiatry, 2017;0(0):.
  22. Regulators of Salmonella-host interaction identified by peripheral blood transcriptome profiling: roles of TGFB1 and TRP53 in intracellular Salmonella replication in pigs
    T Huang, X Huang, B Shi, F Wang, W Feng, M Yao
    Vet. Res., 2018;49(1):121.
  23. JNK inhibitor SP600125 enhances TGF-beta-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner.
    Lin Y, Zhang B, Liang H, Lu Y, Ai X, Zhang B, Chen X
    Mol Med Rep, 2013;8(6):1623-9.
  24. Transcriptionally and Functionally Distinct Mesenchymal Subpopulations Are Generated from Human Pluripotent Stem Cells
    CJ Chin, S Li, M Corselli, D Casero, Y Zhu, CB He, R Hardy, B Péault, GM Crooks
    Stem Cell Reports, 2018;0(0):.
  25. Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice
    A Moritake, N Kawao, K Okada, K Tatsumi, M Ishida, K Okumoto, O Matsuo, M Akagi, H Kaji
    BMC Musculoskelet Disord, 2017;18(1):392.
  26. GDF10 is a signal for axonal sprouting and functional recovery after stroke.
    Li S, Nie E, Yin Y, Benowitz L, Tung S, Vinters H, Bahjat F, Stenzel-Poore M, Kawaguchi R, Coppola G, Carmichael S
    Nat Neurosci, 2015;18(12):1737-45.
  27. A combination of curcumin and oligomeric proanthocyanidins offer superior anti-tumorigenic properties in colorectal cancer
    P Ravindrana, D Pasham, U Balaji, J Cardenas, J Gu, S Toden, A Goel
    Sci Rep, 2018;8(1):13869.
  28. Increased susceptibility to a? toxicity in neuronal cultures derived from familial Azheimer's disease (PSEN1-A246E) induced pluripotent stem cells
    Enrique Armijo
    Neurosci. Lett, 2016;0(0):.
  29. Dynamic Sialylation in Transforming Growth Factor-beta (TGF-beta)-induced Epithelial to Mesenchymal Transition.
    Du J, Hong S, Dong L, Cheng B, Lin L, Zhao B, Chen Y, Chen X
    J Biol Chem, 2015;290(19):12000-13.
  30. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling
    Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que
    Cell Stem Cell, 2018;0(0):.
  31. Principles of early human development and germ cell program from conserved model systems
    T Kobayashi, H Zhang, WWC Tang, N Irie, S Withey, D Klisch, A Sybirna, S Dietmann, DA Contreras, R Webb, C Allegrucci, R Alberio, MA Surani
    Nature, 2017;546(7658):416-420.
  32. TGF-? induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma
    N Tellios, JC Belrose, AC Tokarewicz, C Hutnik, H Liu, A Leask, M Motolko, M Iijima, SK Parapuram
    Sci Rep, 2017;7(1):812.
  33. p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration
    C Turnquist, I Horikawa, E Foran, EO Major, B Vojtesek, DP Lane, X Lu, BT Harris, CC Harris
    Cell Death Differ, 2016;0(0):.
  34. Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy.
    Okumura N, Minamiyama R, Ho L, Kay E, Kawasaki S, Tourtas T, Schlotzer-Schrehardt U, Kruse F, Young R, Quantock A, Kinoshita S, Koizumi N
    Lab Invest, 2015;95(11):1291-304.
  35. Fibrodysplasia ossificans progressiva-related activated activin-like kinase signaling enhances osteoclast formation during heterotopic ossification in muscle tissues.
    Yano M, Kawao N, Okumoto K, Tamura Y, Okada K, Kaji H
    J Biol Chem, 2014;289(24):16966-77.
  36. BMP and TGF-beta pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells.
    Cai J, Schleidt S, Pelta-Heller J, Hutchings D, Cannarsa G, Iacovitti L
    Dev Biol, 2013;376(1):62-73.
  37. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells
    F Sampazioti, MC de Brito, I Geti, A Bertero, NR Hannan, L Vallier
    Nat Protoc, 2017;12(4):814-827.
  38. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
    Cebola I, Rodriguez-Segui S, Cho C, Bessa J, Rovira M, Luengo M, Chhatriwala M, Berry A, Ponsa-Cobas J, Maestro M, Jennings R, Pasquali L, Moran I, Castro N, Hanley N, Gomez-Skarmeta J, Vallier L, Ferrer J
    Nat Cell Biol, 2015;17(5):615-26.
  39. Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells.
    Aguila J, Blak A, van Arensbergen J, Sousa A, Vazquez N, Aduriz A, Gayosso M, Lopez Mato M, Lopez de Maturana R, Hedlund E, Sonntag K, Sanchez-Pernaute R
    Stem Cells Transl Med, 2014;3(9):1032-42.
  40. Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-beta Signaling in the Retinal Pigment Epithelium.
    Li Y, Song D, Song Y, Zhao L, Wolkow N, Tobias J, Song W, Dunaief J
    J Biol Chem, 2015;290(19):11918-34.
  41. Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells
    M Jeong, M O'Reilly, NK Kirkwood, J Al-Aama, M Lako, CJ Kros, L Armstrong
    Cell Death Dis, 2018;9(9):922.
  42. Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
    Cheung C, Bernardo AS, Trotter MW
    Nat. Biotechnol., 2012;30(2):165-73.
  43. TGF-?1 (Transforming Growth Factor-?1) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity
    N Salvarani, A Maguy, SA De Simone, M Miragoli, F Jousset, S Rohr
    Circ Arrhythm Electrophysiol, 2017;10(5):e004567.
  44. Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
    JC Chiang, J Jiang, PE Newburger, JB Lawrence
    Nat Commun, 2018;9(1):5180.
  45. Integrin-mediated type II TGF-beta receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
    Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang Z, Vega-Montoto L, Vanacore R, Fassler R, Zent R, Pozzi A
    J Clin Invest, 2014;124(8):3295-310.
  46. Barrier properties and transcriptome expression in human iPSC-derived models of the blood-brain barrier
    L Delsing, P Dönnes, J Sánchez, M Clausen, D Voulgaris, A Falk, A Herland, G Brolén, H Zetterberg, R Hicks, J Synnergren
    Stem Cells, 2018;0(0):.
  47. Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
    AJ Alshawaf, S Viventi, W Qiu, G D'Abaco, B Nayagam, M Erlichster, G Chana, I Everall, J Ivanusic, E Skafidas, M Dottori
    Sci Rep, 2018;8(1):603.
  48. Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation.
    Yasmin N, Bauer T, Modak M, Wagner K, Schuster C, Koffel R, Seyerl M, Stockl J, Elbe-Burger A, Graf D, Strobl H
    J Exp Med, 2013;210(12):2597-610.
  49. Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System
    Alessandra Rigamonti
    Stem Cell Reports, 2016;6(6):993-1008.
  50. Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.
    Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
    Stem Cell Reports, 2014;2(5):648-61.
  51. Generation of multipotent foregut stem cells from human pluripotent stem cells.
    Hannan, Nicholas, Fordham, Robert P, Syed, Yasir A, Moignard, Victoria, Berry, Andrew, Bautista, Ruben, Hanley, Neil A, Jensen, Kim B, Vallier, Ludovic
    Stem Cell Reports, 2013;1(4):293-306.
  52. Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response
    M Bernhardt, D Novak, Y Assenov, E Orouji, N Knappe, K Weina, M Reith, L Larribere, C Gebhardt, C Plass, V Umansky, J Utikal
    Stem Cell Reports, 2017;0(0):.
  53. Endogenously produced Indian Hedgehog regulates TGFbeta-driven chondrogenesis of human bone marrow stromal/stem cells.
    Handorf A, Chamberlain C, Li W
    Stem Cells Dev, 2015;24(8):995-1007.
  54. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain.
    Deverman B, Pravdo P, Simpson B, Kumar S, Chan K, Banerjee A, Wu W, Yang B, Huber N, Pasca S, Gradinaru V
    Nat Biotechnol, 2015;34(2):204-9.
  55. Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways.
    Kulkarni N, Yi Z, Huehnken C, Agerberth B, Gudmundsson G
    Mol Immunol, 2015;63(2):530-9.
  56. Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-?-Slug signaling

    Proc Natl Acad Sci USA, 2016;113(30):E4320-7.
  57. Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells.
    Rafiei S, Komarova S
    BMC Cancer, 2013;13(0):605.
  58. Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.
    He Q, Wang G, Wakade S, Dasgupta S, Dinkins M, Kong J, Spassieva S, Bieberich E
    Mol Biol Cell, 2014;25(11):1715-29.
  59. Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.
    Orlova, Valeria, Drabsch, Yvette, Freund, Christia, Petrus-Reurer, Sandra, van den Hil, Francijn, Muenthaisong, Suchitra, Dijke, Peter Te, Mummery, Christin
    Arterioscler Thromb Vasc Biol, 2014;34(1):177-86.
  60. Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.
    Pereira, Maria, Pfisterer, Ulrich, Rylander, Daniella, Torper, Olof, Lau, Shong, Lundblad, Martin, Grealish, Shane, Parmar, Malin
    Sci Rep, 2014;4(0):6330.
  61. Derivation and characterization of putative craniofacial mesenchymal progenitor cells from human induced pluripotent stem cells
    M Jamal, SL Lewandowsk, ML Lawton, GT Huang, L Ikonomou
    Stem Cell Res, 2018;33(0):100-109.
  62. A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium.
    Ferrer M, Corneo B, Davis J, Wan Q, Miyagishima K, King R, Maminishkis A, Marugan J, Sharma R, Shure M, Temple S, Miller S, Bharti K
    Stem Cells Transl Med, 2014;3(8):911-22.
  63. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus
    N Avaliani, U Pfisterer, A Heuer, M Parmar, M Kokaia, M Andersson
    Stem Cells Int, 2017;2017(0):5718608.
  64. Inhibition of transforming growth factor beta (TGF-beta) signaling can substitute for Oct4 protein in reprogramming and maintain pluripotency.
    Tan F, Qian C, Tang K, Abd-Allah S, Jing N
    J Biol Chem, 2015;290(7):4500-11.
  65. TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement.
    Bialas A, Stevens B
    Nat Neurosci, 2013;16(12):1773-82.
  66. A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family
    J Li, C Narayanan, J Bian, D Sambo, T Brickler, W Zhang, S Chetty
    PLoS ONE, 2018;13(12):e0208110.
  67. Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.
    Weedon M, Cebola I, Patch A, Flanagan S, De Franco E, Caswell R, Rodriguez-Segui S, Shaw-Smith C, Cho C, Lango Allen H, Houghton J, Roth C, Chen R, Hussain K, Marsh P, Vallier L, Murray A, Ellard S, Ferrer J, Hattersley A
    Nat Genet, 2014;46(1):61-4.
  68. Loss of Klotho contributes to kidney injury by derepression of Wnt/beta-catenin signaling.
    Zhou L, Li Y, Zhou D, Tan R, Liu Y
    J Am Soc Nephrol, 2013;24(5):771-85.
  69. miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification

    Proc Natl Acad Sci USA, 2016;0(0):.
  70. Hepatitis C virus depends on E-cadherin as an entry factor and regulates its expression in epithelial-to-mesenchymal transition
    Qisheng Li
    Proc Natl Acad Sci USA, 2016;0(0):.
  71. A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model
    X Yuan, Z Li, AC Baines, E Gavriilaki, Z Ye, Z Wen, EM Braunstein, LG Biesecker, L Cheng, X Dong, RA Brodsky
    PLoS ONE, 2017;12(4):e0174074.
  72. Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells.
    Bayin, N Sumru, Modrek, Aram S, Dietrich, August, Lebowitz, Jonathan, Abel, Tobias, Song, Hae-Ri, Schober, Markus, Zagzag, David, Buchholz, Christia, Chao, Moses V, Placantonakis, Dimitris
    PLoS ONE, 2014;9(12):e116114.
  73. Generation and assembly of human brain region-specific three-dimensional cultures
    SA Sloan, J Andersen, AM Pa?ca, F Birey, SP Pa?ca
    Nat Protoc, 2018;0(0):.
  74. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.
    Li C, Peart N, Xuan Z, Lewis D, Xia Y, Jin J
    Cell Signal, 2014;26(7):1369-78.
  75. TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Suresh Babu S, Valdez Y, Xu A, O'Byrne A, Calvo F, Lei V, Conway E
    BMC Cancer, 2014;14(0):113.
  76. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.
    Barmada, Sami J, Serio, Andrea, Arjun, Arpana, Bilican, Bilada, Daub, Aaron, Ando, D Michae, Tsvetkov, Andrey, Pleiss, Michael, Li, Xingli, Peisach, Daniel, Shaw, Christop, Chandran, Siddhart, Finkbeiner, Steven
    Nat Chem Biol, 2014;10(8):677-85.
  77. GLIS3 Transcriptionally Activates WNT Genes to Promote Differentiation of Human Embryonic Stem Cells into Posterior Neural Progenitors
    K Jeon, D Kumar, AE Conway, K Park, R Jothi, AM Jetten
    Stem Cells, 2018;0(0):.
  78. TGF-? and Physiological Root Resorption of Deciduous Teeth

    Int J Mol Sci, 2016;18(1):.
  79. Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Via Multiple Distinct Biochemical Pathways

    Stem Cells Dev., 2016;0(0):.
  80. Generation of robust vascular networks from cardiovascular blast populations derived from human induced pluripotent stem cells in vivo and ex vivo organ culture system.
    Kawamoto T, Kobayashi Y, Nakajima H, Yamagishi Y
    Biochem Biophys Res Commun, 2013;441(1):180-5.
  81. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    Hadland B, Varnum-Finney B, Poulos M, Moon R, Butler J, Rafii S, Bernstein I
    J Clin Invest, 2015;125(5):2032-45.
  82. Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes.
    Maury Y, Come J, Piskorowski R, Salah-Mohellibi N, Chevaleyre V, Peschanski M, Martinat C, Nedelec S
    Nat Biotechnol, 2015;33(1):89-96.
  83. Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons
    N Bayó-Puxan, AP Terrasso, S Creyssels, D Simão, C Begon-Pesc, M Lavigne, S Salinas, F Bernex, A Bosch, V Kalatzis, T Levade, AM Cuervo, P Lory, A Consiglio, C Brito, EJ Kremer
    Sci Rep, 2018;8(1):16644.
  84. Nodal signaling regulates the entry into meiosis in fetal germ cells.
    Souquet B, Tourpin S, Messiaen S, Moison D, Habert R, Livera G
    Endocrinology, 2012;153(5):2466-73.
  85. Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation
    KE Worley, AS Chin, LQ Wan
    Stem Cells Int, 2018;2018(0):1848605.
  86. Assembly of functionally integrated human forebrain spheroids
    F Birey, J Andersen, CD Makinson, S Islam, W Wei, N Huber, HC Fan, KRC Metzler, G Panagiotak, N Thom, NA O'Rourke, LM Steinmetz, JA Bernstein, J Hallmayer, JR Huguenard, SP Pa?ca
    Nature, 2017;545(7652):54-59.
  87. Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.
    Maroof A, Keros S, Tyson J, Ying S, Ganat Y, Merkle F, Liu B, Goulburn A, Stanley E, Elefanty A, Widmer H, Eggan K, Goldstein P, Anderson S, Studer L
    Cell Stem Cell, 2013;12(5):559-72.
  88. The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway.
    Wilson C, Ottewell P, Coleman R, Holen I
    BMC Cancer, 2015;15(0):55.
  89. Small molecules increase direct neural conversion of human fibroblasts

    Sci Rep, 2016;6(0):38290.
  90. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.
    Edri, Reuven, Yaffe, Yakey, Ziller, Michael, Mutukula, Naresh, Volkman, Rotem, David, Eyal, Jacob-Hirsch, Jasmine, Malcov, Hagar, Levy, Carmit, Rechavi, Gideon, Gat-Viks, Irit, Meissner, Alexande, Elkabetz, Yechiel
    Nat Commun, 2015;6(0):6500.
  91. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia
    N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, J Tchieu, MA Soliman, G Lee, JL Casanova, L Studer
    Nat. Med., 2016;22(12):1421-1427.
  92. mTOR-dependent proliferation defect in human ES-derived neural stem cells affected by myotonic dystrophy type 1.
    Denis J, Gauthier M, Rachdi L, Aubert S, Giraud-Triboult K, Poydenot P, Benchoua A, Champon B, Maury Y, Baldeschi C, Scharfmann R, Pietu G, Peschanski M, Martinat C
    J Cell Sci, 2013;126(0):1763-72.
  93. Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells.
    Iyer D, Gambardella L, Bernard W, Serrano F, Mascetti V, Pedersen R, Talasila A, Sinha S
    Development, 2015;142(8):1528-41.
  94. Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
    O'Reilly S, Ciechomska M, Cant R, van Laar J
    J Biol Chem, 2014;289(14):9952-60.
  95. SMAD-independent down-regulation of caveolin-1 by TGF-beta: effects on proliferation and survival of myofibroblasts.
    Sanders Y, Cui Z, Le Saux C, Horowitz J, Rangarajan S, Kurundkar A, Antony V, Thannickal V
    PLoS ONE, 2015;10(2):e0116995.
  96. Physiological characterisation of human iPS-derived dopaminergic neurons.
    Hartfield, Elizabet, Yamasaki-Mann, Michiko, Ribeiro Fernandes, Hugo J, Vowles, Jane, James, William, Cowley, Sally A, Wade-Martins, Richard
    PLoS ONE, 2014;9(2):e87388.
  97. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Huang, Sarah X, Islam, Mohammad, O'Neill, John, Hu, Zheng, Yang, Yong-Gua, Chen, Ya-Wen, Mumau, Melanie, Green, Michael, Vunjak-Novakovic, Gordana, Bhattacharya, Jahar, Snoeck, Hans-Wil
    Nat Biotechnol, 2014;32(1):84-91.
  98. A New Glucocerebrosidase Chaperone Reduces ?-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

    J Neurosci, 2016;36(28):7441-52.
  99. TGFbeta1 protects cells from gamma-IR by enhancing the activity of the NHEJ repair pathway.
    Kim M, Lee J, An Y, Jin Y, Park I, Chung E, Shin I, Barcellos-Hoff M, Yi J
    Mol Cancer Res, 2015;13(2):319-29.
  100. HEB associates with PRC2 and SMAD2/3 to regulate developmental fates.
    Yoon, Se-Jin, Foley, Joseph W, Baker, Julie C
    Nat Commun, 2015;6(0):6546.
  101. TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells.
    Watabe et al.
    J.Cell Biol., 2003;163:163
  102. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.
    Halder et al.
    Neoplasia, 2005;7:509
  103. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I AVNreceptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.
    Inman et al.
    Mol.Pharmacol., 2002;62:65
  104. Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542.
    Laping et al.
    Mol.Pharmacol., 2002;62:58
  105. SB-431542 and Gle. inhibit transforming growth factor-β-induced proliferation of human osteosarcoma cells.
    Matsuyama et al.
    Cancer Res., 2003;63:7791
  106. miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7
    M Wang, L Xiong, LJ Jiang, YZ Lu, F Liu, LJ Song, F Xiang, XL He, F Yu, SY Shuai, WL Ma, H Ye
    EBioMedicine, 2019;41(0):670-682.
  107. Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures
    RM Marton, Y Miura, SA Sloan, Q Li, O Revah, RJ Levy, JR Huguenard, SP Pa?ca
    Nat. Neurosci., 2019;0(0):.
  108. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
    FH Siddiqi, FM Menzies, A Lopez, E Stamatakou, C Karabiyik, R Ureshino, T Ricketts, M Jimenez-Sa, MA Esteban, L Lai, MD Tortorella, Z Luo, H Liu, E Metzakopia, HJR Fernandes, A Bassett, E Karran, BL Miller, A Fleming, DC Rubinsztei
    Nat Commun, 2019;10(1):1817.
  109. Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs
    M Chen, SH Laursen, M Habekost, CH Knudsen, SH Buchholdt, J Huang, F Xu, X Liu, L Bolund, Y Luo, P Nissen, F Febbraro, M Denham
    Front Cell Dev Biol, 2018;6(0):5.
  110. Intracellular pH Regulation in iPSCs-derived Astrocytes from Subjects with Chronic Mountain Sickness
    H Yao, H Zhao, J Wang, GG Haddad
    Neuroscience, 2018;0(0):.
  111. Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons
    T Ahfeldt, A Ordureau, C Bell, L Sarrafha, C Sun, S Piccinotti, T Grass, GM Parfitt, JA Paulo, F Yanagawa, T Uozumi, Y Kiyota, JW Harper, LL Rubin
    Stem Cell Reports, 2020;14(1):75-90.
  112. Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
    MP Zafeiriou, G Bao, J Hudson, R Halder, A Blenkle, MK Schreiber, A Fischer, D Schild, WH Zimmermann
    Nat Commun, 2020;11(1):3791.
  113. Neuronal impact of patient-specific aberrant NRXN1alpha splicing
    E Flaherty, S Zhu, N Barretto, E Cheng, PJM Deans, MB Fernando, N Schrode, N Francoeur, A Antoine, K Alganem, M Halpern, G Deikus, H Shah, M Fitzgerald, I Ladran, P Gochman, J Rapoport, NM Tsankova, R McCullumsm, GE Hoffman, R Sebra, G Fang, KJ Brennand
    Nat. Genet., 2019;51(12):1679-1690.
  114. Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2
    F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen
    Res Sq, 2020;0(0):.
  115. Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease
    CW Gantner, IR de Luzy, JA Kauhausen, N Moriarty, JC Niclis, CR Bye, V Penna, CPJ Hunt, CM Ermine, CW Pouton, D Kirik, LH Thompson, CL Parish
    Cell Stem Cell, 2020;0(0):.
  116. Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells
    Y Miura, MY Li, F Birey, K Ikeda, O Revah, MV Thete, JY Park, A Puno, SH Lee, MH Porteus, SP Pa?ca
    Nature Biotechnology, 2020;38(12):1421-1430.
  117. Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis
    JW Kim, X Yin, A Jhaldiyal, MR Khan, I Martin, Z Xie, T Perez-Rose, M Kumar, L Abalde-Atr, J Xu, L Chen, SM Eacker, DJ Surmeier, NT Ingolia, TM Dawson, VL Dawson
    Cell Stem Cell, 2020;27(4):633-645.e7.
  118. S-endoglin expression is induced in hyperoxia and contributes to altered pulmonary angiogenesis in bronchopulmonary dysplasia development
    Y Lee, J Lee, SK Nam, Y Hoon Jun
    Sci Rep, 2020;10(1):3043.
  119. Human stem cells harboring a suicide gene improve the�safety and standardisation of neural transplants in Parkinsonian rats
    IR de Luzy, KCL Law, N Moriarty, CPJ Hunt, JC Durnall, LH Thompson, A Nagy, CL Parish
    Nature Communications, 2021;12(1):3275.
  120. Attenuation of apoptotic cell detection triggers thymic regeneration after damage
    S Kinsella, CA Evandy, K Cooper, L Iovino, PC deRoos, KS Hopwo, DW Granadier, CW Smith, S Rafii, JA Dudakov
    Cell Reports, 2021;37(1):109789.
  121. Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica
    Y Hong, S Shan, Y Gu, H Huang, Q Zhang, Y Han, Y Dong, Z Liu, M Huang, T Ren
    Nature Communications, 2022;13(1):1309.
  122. ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation
    J Zhou, H He, JJ Zhang, X Liu, W Yao, C Li, T Xu, SY Yin, DY Wu, CL Dou, Q Li, J Xiang, WJ Xiong, LY Wang, JM Tang, Z Xue, X Zhang, YL Miao
    Autophagy, 2022;0(0):.
  123. TGFbeta1-Smad canonical and -Erk noncanonical pathways participate in interleukin-17-induced epithelial-mesenchymal transition in Sj�gren's syndrome
    M Sisto, L Lorusso, G Ingravallo, D Ribatti, S Lisi
    Lab. Invest., 2020;100(6):824-836.
  124. Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate
    TM Lu, S Houghton, T Magdeldin, JGB Durán, AP Minotti, A Snead, A Sproul, DT Nguyen, J Xiang, HA Fine, Z Rosenwaks, L Studer, S Rafii, D Agalliu, D Redmond, R Lis
    Proceedings of the National Academy of Sciences of the United States of America, 2021;118(8):.
  125. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use
    TW Kim, J Piao, SY Koo, S Kriks, SY Chung, D Betel, ND Socci, SJ Choi, S Zabierowsk, BN Dubose, EJ Hill, EV Mosharov, S Irion, MJ Tomishima, V Tabar, L Studer
    Cell Stem Cell, 2021;28(2):343-355.e5.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SB 431542

The citations listed below are publications that use Tocris products. Selected citations for SB 431542 include:

263 Citations: Showing 1 - 10

  1. Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons.
    Authors: Hergenreder Et al.
    Nat.Biotechnol.  2024;
  2. An in vivo neuroimmune organoid model to study human microglia phenotypes.
    Authors: Schafer
    Cell  2023;186:2111
  3. An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells
    Authors: Surendran Et al.
    STAR Protoc  2022;3:101803
  4. Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells.
    Authors: Rosebrock Et al.
    Nat Cell Biol  2022;24:981
  5. Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use.
    Authors: Kim Et al.
    Cell Stem Cell  2021;28:343
  6. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01
    Authors: Piao Et al.
    Cell Stem Cell  2021;28:217
  7. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: Yang Et al.
    Cell Stem Cell  2020;27:125
  8. Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate.
    Authors: Frith and Tsakiridis
    Curr Protoc Stem Cell Biol  2019;:e81
  9. Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors.
    Authors: Baror Et al.
    Glia  2019;67:1374
  10. Neurons Derived from Human Induced Pluripotent Stem Cells Integrate into Rat Brain Circuits and Maintain Both Excitatory and Inhibitory Synaptic Activities.
    Authors: Yin Et al.
    Eneuro  2019;6
  11. Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart.
    Authors: Bise Et al.
    NPJ Regen Med  2019;4:2
  12. Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm.
    Authors: Sharma Et al.
    Arterioscler Thromb Vasc Biol  2019;39:212
  13. Long-term functional maintenance of primary human hepatocytes in vitro.
    Authors: Xiang Et al.
    Science  2019;364:399
  14. A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.
    Authors: Serrano Et al.
    Stem Cells Dev  2019;28:81
  15. Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
    Authors: Paonessa Et al.
    Cell Rep  2019;26:582
  16. Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.
    Authors: Colunga Et al.
    Cell Rep  2019;26:2566
  17. Supporting data on in vitro cardioprotective and proliferative paracrine effects by the human amniotic fluid stem cell secretome.
    Authors: Balbi Et al.
    Data Brief  2019;25:104324
  18. Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
    Authors: Lang Et al.
    Cell Stem Cell  2019;24:93
  19. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells.
    Authors: Montel-Hagen Et al.
    Cell Stem Cell  2019;24:376
  20. Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches.
    Authors: Varghese Et al.
    Stem Cells Int  2019;2019:5968236
  21. Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
    Authors: Nguyen Et al.
    Stem Cells Int  2019;2019:3298432
  22. Reliability of human cortical organoid generation.
    Authors: Yoon Et al.
    Nat Methods  2019;16:75
  23. The Spatiotemporal Control of Zygotic Genome Activation.
    Authors: Gentsch Et al.
    iScience  2019;16:485
  24. An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons.
    Authors: Canfield Et al.
    Fluids Barriers CNS  2019;16:25
  25. Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.
    Authors: Haidar Et al.
    Autophagy  2019;15:1051
  26. A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology.
    Authors: Yoshimatsu Et al.
    PLoS One  2019;14:e0221164
  27. Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration.
    Authors: Aquino-Martínez Et al.
    PLoS One  2019;14:e0210301
  28. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
    Authors: Garcia Et al.
    Front Neurosci  2019;13:669
  29. Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways.
    Authors: Yin Et al.
    Stem Cell Reports  2019;12:488
  30. Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo.
    Authors: Easterbrook Et al.
    Stem Cell Reports  2019;12:1056
  31. Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals.
    Authors: Gentsch Et al.
    Nat Commun  2019;10:4269
  32. Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.
    Authors: Caron Et al.
    Stem Cell Res Ther  2019;10:221
  33. A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
    Authors: Sheng Et al.
    Nat Commun  2018;9:4047
  34. Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids.
    Authors: Magro-Lopez Et al.
    Stem Cell Res.Ther.  2018;9:186
  35. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
    Authors: Caires-J?nior
    Nat Commun  2018;9(1):475
  36. Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish.
    Authors: Yang Et al.
    Sci Rep  2018;8:8495
  37. Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.
    Authors: Bayo-Puxan Et al.
    Sci Rep  2018;8:16644
  38. Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.
    Authors: Hsu Et al.
    Elife  2018;7
  39. Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling.
    Authors: Subramanian Et al.
    Elife  2018;7
  40. TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.
    Authors: Smyth Et al.
    Int J Parasitol  2018;48:379
  41. Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells.
    Authors: McCauley Et al.
    Curr Protoc Stem Cell Biol  2018;45:e51
  42. Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.
    Authors: Noskovičová Et al.
    Am J Physiol Lung Cell Mol Physiol  2018;314:L695
  43. Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.
    Authors: Bernard Et al.
    J Biol Chem  2018;293:1218
  44. Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation.
    Authors: Mehta Et al.
    Cell Rep  2018;25:1081
  45. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
    Authors: Wang
    Nat Med  2018;24(5):647
  46. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.
    Authors: Nehme Et al.
    Cell Rep  2018;23:2509
  47. Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
    Authors: Sommer Et al.
    Cell Stem Cell.  2018;23:123
  48. The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development.
    Authors: Tebbenkamp Et al.
    Cell  2018;175:1088
  49. Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
    Authors: Wu Et al.
    Cell  2018;172:423
  50. MAPK and GSK3/�-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo.
    Authors: Molina Et al.
    PLoS Genet  2018;14:e1007621
  51. Generation and assembly of human brain region-specific three-dimensional cultures.
    Authors: Sloan Et al.
    Nat Protoc  2018;13:2062
  52. BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.
    Authors: Raykhel Et al.
    J Cell Sci  2018;131
  53. Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells.
    Authors: Li Et al.
    Stem Cell Reports  2018;11:998
  54. Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain.
    Authors: Fr?hlich Et al.
    Front Mol Neurosci  2018;11:81
  55. TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation.
    Authors: Albers Et al.
    Int J Stem Cells  2018;11:111
  56. Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.
    Authors: Medelnik Et al.
    Stem Cell Reports  2018;10:1751
  57. Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
    Authors: Sloan Et al.
    Neuron  2017;95:779
  58. MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.
    Authors: Offermann Et al.
    Oncotarget  2017;8:7964
  59. Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
    Authors: Subramanian Et al.
    Nat Commun  2017;8:14167
  60. Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage.
    Authors: Christoforou Et al.
    Sci Rep  2017;7:40285
  61. Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
    Authors: Kunnen Et al.
    Cell Mol Life Sci  2017;74:2283
  62. Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation.
    Authors: Song Et al.
    Mol Cell  2017;67:148
  63. Learning induces the translin/trax RNase complex to express activ. receptors for persistent memory.
    Authors: Park Et al.
    Elife  2017;6
  64. Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.
    Authors: Takata Et al.
    Immunity  2017;47:183
  65. Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.
    Authors: Charney Et al.
    Dev Cell  2017;40:595
  66. Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma.
    Authors: Yang Et al.
    Cell Mol Gastroenterol Hepatol  2017;3:484
  67. Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells.
    Authors: Major Et al.
    Curr Protoc Stem Cell Biol  2017;39:1H.10.1
  68. Chemotherapy enhances programmed cell death 1/ligand 1 expression via TGF-β induced epithelial mesenchymal transition in non-small cell lung cancer.
    Authors: Funaki Et al.
    Oncol Rep  2017;38:2277
  69. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.
    Authors: Ruetz Et al.
    Cell Stem Cell  2017;21:791
  70. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
    Authors: Kotton Et al.
    Cell Stem Cell.  2017;21:472
  71. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell  2017;21:399
  72. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.
    Authors: McCauley Et al.
    Cell Stem Cell  2017;20:844
  73. Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration.
    Authors: Saini Et al.
    Cell Stem Cell  2017;20:635
  74. Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.
    Authors: Bershteyn Et al.
    Cell Stem Cell  2017;20:435
  75. In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
    Authors: Xi
    Cell Rep  2017;18(6):1573
  76. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.
    Authors: de la Mare
    BMC Cancer  2017;17(1):202
  77. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
    Authors: Yang Et al.
    Cell  2017;169:243
  78. p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation.
    Authors: Molina Et al.
    Development  2017;144:2270
  79. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.
    Authors: Sampaziotis Et al.
    Nat Protoc  2017;12:814
  80. Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions.
    Authors: Bao Et al.
    Nat Protoc  2017;12:1890
  81. Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers.
    Authors: Guo Et al.
    Biomaterials  2017;122:179
  82. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
    Authors: Young
    Proc Natl Acad Sci U S A.  2017;114(28):E5599
  83. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices.
    Authors: Oenema Et al.
    Stem Cells  2016;8:e65580
  84. Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.
    Authors: Spender Et al.
    Oncotarget  2016;7:81995
  85. Human fetal and adult epicardial-derived cells: a novel model to study their activation
    Authors: Moerkamp Et al.
    Stem Cell Research & Therapy  2016;7:174
  86. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
    Authors: Kapeli Et al.
    Nature Communications  2016;7:12143
  87. Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
    Authors: Vargel Et al.
    Nat Protoc  2016;6:21518
  88. Generating trunk neural crest from human pluripotent stem cells.
    Authors: Huang Et al.
    Sci Rep  2016;6:19727
  89. The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of AVNA/TGFβ and β1 integrin signalling.
    Authors: Morris Et al.
    Mol Cell Biol  2016;6:19533
  90. Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer.
    Authors: Buczek Et al.
    Oncogene  2016;35:3465
  91. Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation.
    Authors: Genbacev Et al.
    Hum Reprod  2016;31:1300
  92. Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.
    Authors: Topalovski Et al.
    J Biol Chem  2016;291:22244
  93. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
    Authors: Zeltner Et al.
    Nat Med  2016;22:1421
  94. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  95. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.
    Authors: Nott Et al.
    Nat Neurosci  2016;19:1497
  96. AVNA programs the differentiation of human TFH cells.
    Authors: Locci Et al.
    Nat Immunol  2016;17:976
  97. Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
    Authors: Manno Et al.
    Cell  2016;167:566
  98. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.
    Authors: Maturana Et al.
    J Neuroinflammation  2016;13:295
  99. A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes
    Authors: Sulaiman Et al.
    PLoS Pathogens  2016;12:e1005991
  100. Collagen XII contributes to epicardial and connective tissues in the Zebrafish heart during ontogenesis and regeneration
    Authors: Marro Et al.
    PLoS One  2016;11:e0165497
  101. Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells.
    Authors: Ghaedi and Niklason
    Methods Mol Biol  2016;
  102. Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta.
    Authors: Tabata Et al.
    Sci Rep  2015;89:5134
  103. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
    Authors: Rempel Et al.
    Arch Toxicol  2015;89:1599
  104. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
    Authors: Sakaguchi Et al.
    Mol Neurobiol  2015;6:8896
  105. Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
    Authors: Aspalter Et al.
    Nat Commun  2015;6:7264
  106. The Nodal signaling pathway controls left-right asymmetric development in amphioxus.
    Authors: Soukup Et al.
    J Clin Invest  2015;6:5
  107. Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury.
    Authors: Oh Et al.
    Stem Cell Res Ther  2015;6:125
  108. Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish.
    Authors: Yan Et al.
    J Hepatol  2015;63:420
  109. Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells.
    Authors: Honsho Et al.
    BMC Cancer  2015;61:42626
  110. Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.
    Authors: Agu Et al.
    Exp Neurol  2015;5:660
  111. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency.
    Authors: Singh Et al.
    Stem Cells Dev  2015;5:323
  112. Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.
    Authors: Ramnath Et al.
    Evodevo  2015;5:16872
  113. A key role for TGF-β1 in hippocampal synaptic plasticity and memory.
    Authors: Caraci Et al.
    PLoS Comput Biol  2015;5:11252
  114. Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.
    Authors: Imaizumi Et al.
    J Clin Invest  2015;5:1010
  115. Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.
    Authors: Ooi Et al.
    PLoS One  2015;52:1850
  116. TGFβ2 regulates hypothalamic Trh expression through the TGFβ inducible early gene-1 (TIEG1) during fetal development.
    Authors: Martínez-Armenta Et al.
    J Clin Invest  2015;400:129
  117. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
    Authors: Kumar Et al.
    Elife  2015;4
  118. Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells.
    Authors: Lages Et al.
    J Reprod Dev  2015;3:e1486
  119. TGFβ loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
    Authors: Bras Et al.
    Mol Med  2015;330:29
  120. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.
    Authors: Niederst Et al.
    Hum Mol Genet  2015;26:205
  121. Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.
    Authors: Saporta Et al.
    Nat Commun  2015;263:190
  122. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
    Authors: Sposito Et al.
    Stem Cell Reports  2015;24:5260
  123. Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling.
    Authors: Hu Et al.
    J Virol  2015;24:2591
  124. Pen. Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-κB and Smad2/3 Signaling.
    Authors: Chen Et al.
    Brain  2015;21:276
  125. Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.
    Authors: Zhang Et al.
    Cell Stem Cell  2015;17:735
  126. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
    Authors: Cebola Et al.
    Mol Cell Endocrinol  2015;17:615
  127. Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
    Authors: Piao Et al.
    Cell Stem Cell  2015;16:198
  128. The differential anti-tumour effects of Zol. acid in breast cancer - evidence for a role of the AVNsignaling pathway.
    Authors: Wilson Et al.
    Sci Rep  2015;15:55
  129. Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.
    Authors: Jönsson Et al.
    Stem Cell Reports  2015;142:3166
  130. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
    Authors: Iovino Et al.
    Development  2015;138:3345
  131. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
    Authors: Pasca Et al.
    Nat Methods  2015;12:671
  132. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
    Authors: Li Et al.
    Sci Rep  2015;125:3008
  133. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    Authors: Hadland Et al.
    Nat Cell Biol  2015;125:2032
  134. Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.
    Authors: Ziv Et al.
    Mol Biol Cell  2015;11:e1004453
  135. TGF-β Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells.
    Authors: Kawahara Et al.
    PeerJ  2015;10:e0125590
  136. Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation.
    Authors: Woods Et al.
    PLoS One  2015;10:e0123641
  137. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts.
    Authors: Sanders Et al.
    PLoS One  2015;10:e0116995
  138. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Exp Cell Res  2015;10:413
  139. Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state.
    Authors: Ginsberg Et al.
    Nat Protoc  2015;10:1975
  140. Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells.
    Authors: Nishimura Et al.
    PLoS One  2014;9:e91269
  141. Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients.
    Authors: Grunseich Et al.
    Neurobiol Dis  2014;70:12
  142. Combining TGF-β signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes.
    Authors: Dai Et al.
    PLoS One  2014;4:7323
  143. Immunoevasive pericytes from human pluripotent stem cells preferentially modulate induction of allogeneic regulatory T cells.
    Authors: Domev Et al.
    Stem Cells Transl Med  2014;3:1169
  144. Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for DA Neurons From Human Pluripotent Stem Cells.
    Authors: Aguila Et al.
    Stem Cells Transl Med  2014;3:1032
  145. miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells.
    Authors: Rosa Et al.
    Dev Biol  2014;391:81
  146. Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation.
    Authors: Magaña Et al.
    Dev Biol  2014;387:15
  147. ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
    Authors: Curado Et al.
    Exp Neurol  2014;34:4389
  148. Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.
    Authors: Orlova Et al.
    Arterioscler Thromb Vasc Biol  2014;34:177
  149. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol  2014;32:84
  150. Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
    Authors: O'Reilly Et al.
    J Biol Chem  2014;289:9952
  151. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.
    Authors: Wu Et al.
    Fibrogenesis Tissue Repair  2014;289:20193
  152. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.
    Authors: Li Et al.
    Cell Signal  2014;26:1369
  153. Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells.
    Authors: Fang Et al.
    J Pharm Sci Pharmacol  2014;1:175
  154. Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions.
    Authors: Soares Et al.
    Cell Stem Cell  2014;173:53
  155. TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Babu Et al.
    BMC Cancer  2014;14:113
  156. The development of zebrafish tendon and ligament progenitors.
    Authors: Chen
    Development  2014;141:2035
  157. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
    Authors: Wrighton Et al.
    J Cell Sci  2014;111:18126
  158. Profiling of microRNA in human and mouse ES and iPS cells reveals overlapping but distinct microRNA expression patterns.
    Authors: Razak Et al.
    Nat Neurosci  2013;8:e73532
  159. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway.
    Authors: Voon Et al.
    PLoS One  2013;8:e70427
  160. Sustained levels of FGF2 maintain undifferentiated stem cell cultures with biweekly feeding.
    Authors: Lotz Et al.
    PLoS One  2013;8:e56289
  161. A novel model of dormancy for bone metastatic breast cancer cells.
    Authors: Marlow Et al.
    Cancer Res  2013;73:6886
  162. Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.
    Authors: Briones-Orta Et al.
    Am J Stem Cells  2013;73:1800
  163. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
    Authors: Kirkeby Et al.
    Front.Cell Neurosci.  2013;6:64
  164. The presenilin-1 δE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.
    Authors: Woodruff Et al.
    Cell Rep  2013;5:974
  165. Translating dosage compensation to trisomy 21.
    Authors: Jiang Et al.
    Nature  2013;500:296
  166. High-power femtosecond-terahertz pulse induces a wound response in mouse skin.
    Authors: Kim Et al.
    Proc Natl Acad Sci U S A  2013;3:2296
  167. A robust method to derive functional neural crest cells from human pluripotent stem cells.
    Authors: Kreitzer Et al.
    Nat Methods  2013;2:119
  168. Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.
    Authors: Spender Et al.
    J Biol Chem  2013;288:5198
  169. Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells.
    Authors: Honda Et al.
    ACS Chem Neurosci  2013;288:26157
  170. Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate.
    Authors: Pol Et al.
    Stem Cell Res  2013;247:694
  171. Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts.
    Authors: Davila Et al.
    J Neurosci Methods  2013;216:104
  172. Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells.
    Authors: Lee-Chang Et al.
    J Immunol  2013;191:4141
  173. TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement.
    Authors: Bialas and
    Nat Neurosci  2013;16:1773
  174. Identification of repurposed small molecule drugs for chordoma therapy.
    Authors: Xia Et al.
    Cancer Biol Ther  2013;14:638
  175. Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells.
    Authors: Rafiei and Komarova
    BMC Cancer  2013;13:605
  176. TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung.
    Authors: McQualter Et al.
    Stem Cell Res  2013;11:1222
  177. Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.
    Authors: Crompton Et al.
    PLoS One  2013;11:1206
  178. Snail cooperates with KrasG12D to promote pancreatic fibrosis.
    Authors: Shields Et al.
    Mol Cancer Res  2013;11:1078
  179. Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.
    Authors: Shalom-Feuerstein Et al.
    Neuropsychopharmacology  2013;110:2152
  180. Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix.
    Authors: Kusuma Et al.
    Antimicrob Agents Chemother  2013;110:12601
  181. A simple tool to improve pluripotent stem cell differentiation.
    Authors: Chetty Et al.
    Cell  2013;10:553
  182. High-throughput screening assay for embryoid body differentiation of human embryonic stem cells.
    Authors: Outten Et al.
    Curr Protoc Stem Cell Biol  2012;Chapter 1:Unit 1D.6
  183. Modulation of pluripotency in the porcine embryo and iPS cells.
    Authors: Rodríguez Et al.
    Nat Biotechnol  2012;7:e49079
  184. TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence.
    Authors: Sohni Et al.
    PLoS One  2012;7:e47629
  185. Transposon-mediated BAC transgenesis in human ES cells.
    Authors: Rostovskaya Et al.
    Nucleic Acids Res  2012;40:e150
  186. A novel co-operative mechanism linking TGFβ and Lyn kinase activation to Im.nib resistance in chronic myeloid leukaemia cells.
    Authors: Smith Et al.
    PLoS One  2012;3:518
  187. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.
    Authors: Neely Et al.
    Proc Natl Acad Sci U S A  2012;3:482
  188. Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes.
    Authors: Grönroos Et al.
    Mol Cell Biol  2012;32:2904
  189. Glycogen synthase kinase 3β and act./nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage.
    Authors: Denham Et al.
    J Neurosci  2012;30:2400
  190. TGF-β blockade does not improve control of an established persistent viral infection.
    Authors: Boettler Et al.
    Viral Immunol  2012;25:232
  191. Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage.
    Authors: Mak Et al.
    Stem Cells Int  2012;2012:140427
  192. Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
    Authors: Shi Et al.
    Cancer Res  2012;15:477
  193. Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients.
    Authors: Patsialou Et al.
    Breast Cancer Res  2012;14:R139
  194. BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors.
    Authors: Boeuf Et al.
    BMC Cancer  2012;12:488
  195. Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells.
    Authors: Varela Et al.
    Sci Rep  2012;122:569
  196. Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity.
    Authors: Valdez Et al.
    Nature  2012;11:676
  197. Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
    Authors: Luo and Su
    PLoS Biol  2012;10:e1001402
  198. Suppression of AVNA signals inhibits growth of malignant pleural mesothelioma cells.
    Authors: Hoda Et al.
    Br J Cancer  2012;107:1978
  199. Transforming Growth Factor-β1 Antagonizes Interleukin-5 Pro-Survival Signaling by Activating Calpain-1 in Primary Human Eosinophils.
    Authors: Xie Et al.
    Proc Natl Acad Sci U S A  2011;Suppl 1
  200. Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-beta signalling.
    Authors: Kurita and Wada
    Biol Lett  2011;7:759
  201. Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4+ T cells to T-regulatory cells.
    Authors: Olkhanud Et al.
    Cancer Res  2011;71:3505
  202. Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells.
    Authors: Bedel Et al.
    Cancer Res  2011;71:1615
  203. Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.
    Authors: Wilson Et al.
    PLoS One  2011;6:e22842
  204. Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4.
    Authors: Tan Et al.
    Nat Cell Biol  2011;6:e17124
  205. Dedifferentiation of immortalized human podocytes in response to transforming growth factor-β: a model for diabetic podocytopathy.
    Authors: Herman-Edelstein Et al.
    Diabetes  2011;60:1779
  206. Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism.
    Authors: Chen Et al.
    PLoS One  2011;4:9
  207. Increased transforming growth factor β contributes to deterioration of refrigerated fresh frozen plasma's effects in vitro on endothelial cells.
    Authors: Duan Et al.
    J Clin Cell Immunol  2011;36:54
  208. Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells.
    Authors: Seibler Et al.
    Shock  2011;31:5970
  209. Reversible differentiation of myofibroblasts by MyoD.
    Authors: Hecker Et al.
    PLoS One  2011;317:1914
  210. Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression.
    Authors: Dangi-Garimella Et al.
    Oncogene  2011;30:1002
  211. Neural crest cells organize the eye via TGF-β and canonical Wnt signalling.
    Authors: Grocott Et al.
    Stem Cell Reports  2011;2:265
  212. Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble Hep. and heparan sulfate saccharides.
    Authors: Holley Et al.
    J Biol Chem  2011;286:6241
  213. Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion.
    Authors: Shields Et al.
    J Biol Chem  2011;286:10495
  214. β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4.
    Authors: Paek Et al.
    Dev Cell  2011;20:689
  215. A poised chromatin platform for TGF-β access to master regulators.
    Authors: Xi Et al.
    Biochem Biophys Res Commun  2011;147:1511
  216. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
    Authors: Ewan Et al.
    Cancer Res  2010;70:5963
  217. Role of TGF-β1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells.
    Authors: Redondo Et al.
    PLoS One  2010;5:e9800
  218. Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1.
    Authors: Krueger
    PLoS One  2010;5:e15511
  219. Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes.
    Authors: Wang Et al.
    Nat Commun  2010;4:15
  220. Phosphorylation of Junb family proteins by the Jun N-terminal kinase supports tissue regeneration in zebrafish.
    Authors: Ishida Et al.
    Dev Biol  2010;340:468
  221. Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent.
    Authors: James Et al.
    Nat Biotechnol  2010;28:161
  222. Tumor-supportive and osteoclastogenic changes induced by breast cancer-derived factors are reversed by inhibition of {gamma}-secretase.
    Authors: Fong Et al.
    J Biol Chem  2010;285:31427
  223. Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells.
    Authors: Moyano Et al.
    Mol Biol Cell  2010;21:3654
  224. Pig epiblast stem cells depend on act./nodal signaling for pluripotency and self-renewal.
    Authors: Alberio Et al.
    Stem Cells Dev  2010;19:1627
  225. PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins.
    Authors: Ham Et al.
    J Cell Mol Med  2010;14:1747
  226. Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.
    Authors: Hannigan Et al.
    J Clin Invest  2010;120:2842
  227. Extracellular matrix-induced gene expression in human breast cancer cells.
    Authors: Garamszegi Et al.
    Mol Cancer Res  2009;7:319
  228. Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.
    Authors: Patsialou Et al.
    Cancer Res  2009;69:9498
  229. Pharmacological inhibition of transforming growth factor β signaling decreases infection and prevents heart damage in acute Chagas' disease.
    Authors: Waghabi Et al.
    Sci Rep  2009;53:4694
  230. SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism.
    Authors: Xiao Et al.
    Invest Ophthalmol Vis Sci  2009;50:1698
  231. act./Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.
    Authors: Patani Et al.
    Oncotarget  2009;4:e7327
  232. TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature.
    Authors: Walshe Et al.
    PLoS One  2009;4:e5149
  233. Nodal signalling is involved in left-right asymmetry in snails.
    Authors: Grande and Patel
    J Cell Commun Signal  2009;457:1007
  234. Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis.
    Authors: Cacheaux Et al.
    J Neurosci  2009;29:8927
  235. Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics.
    Authors: Clarke Et al.
    Mol Cell Biol  2009;29:2443
  236. Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.
    Authors: Li Et al.
    Stem Cells  2009;27:2992
  237. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling.
    Authors: Chambers Et al.
    J Biotechnol  2009;27:275
  238. Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei.
    Authors: Roussigne Et al.
    Development  2009;136:1549
  239. Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility.
    Authors: Giampieri Et al.
    J Biol Chem  2009;11:1287
  240. Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype.
    Authors: Bharathy Et al.
    Cancer Res  2008;68:1656
  241. Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-α.
    Authors: Ding and Warburton
    Hypertens Res  2008;375:460
  242. TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.
    Authors: Ho and Whitman
    Dev Biol  2008;315:203
  243. Rb/E2F4 and Smad2/3 link survivin to TGF-beta-induced apoptosis and tumor progression.
    Authors: Yang Et al.
    Oncogene  2008;27:5326
  244. A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization.
    Authors: Stoikos Et al.
    Hum Reprod  2008;23:1447
  245. Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor.
    Authors: Gressner Et al.
    J Cell Mol Med  2008;12:2717
  246. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
    Authors: Zhang Et al.
    Blood  2008;111:1933
  247. Low concentrations of transforming growth factor-beta-1 induce tubulogenesis in cultured mammary epithelial cells.
    Authors: Montesano Et al.
    BMC Dev Biol  2007;7:7
  248. The role of maternal act.-like signals in zebrafish embryos.
    Authors: Hagos Et al.
    Dev Biol  2007;309:245
  249. Transforming growth factor: beta signaling is essential for limb regeneration in axolotls.
    Authors: L&eacutevesque Et al.
    PLoS One  2007;2:e1227
  250. AVNacutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I.
    Authors: Zhu Et al.
    J Neurosci  2007;27:13770
  251. Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.
    Authors: Horowitz Et al.
    Cell Signal  2007;19:761
  252. Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules.
    Authors: Dai Et al.
    Mol Biol Cell  2007;18:2264
  253. TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis.
    Authors: Ivens Et al.
    Brain  2007;130:535
  254. Signaling by ALK5 mediates TGF-β-induced ET-1 expression in endothelial cells: a role for migration and proliferation.
    Authors: Castañares Et al.
    Genes Dev  2007;120:1256
  255. PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.
    Authors: Zhao Et al.
    Biochem Biophys Res Commun  2006;350:385
  256. Transforming growth factor-β signaling enhances transdifferentiation of macrophages into smooth muscle-like cells.
    Authors: Ninomiya Et al.
    Mol Cell Biol  2006;29:269
  257. Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.
    Authors: Ho Et al.
    Dev Biol  2006;295:730
  258. Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
    Authors: Shi-Wen Et al.
    Exp Cell Res  2006;26:5518
  259. Identification of phosphatases for Smad in the BMP/DPP pathway.
    Authors: Chen Et al.
    Sci Rep  2006;20:648
  260. Restoration of TGF-beta signalling reduces tumorigenicity in human lung cancer cells.
    Authors: Anumanthan Et al.
    Br J Cancer  2005;93:1157
  261. TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling.
    Authors: König Et al.
    J Cell Biol  2005;168:1077
  262. Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/act.-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
    Authors: Chen Et al.
    Am J Pathol  2005;167:1699
  263. Tra.Mab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma.
    Authors: Mimura Et al.
    Clin Cancer Res  2005;11:4898

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Loading...

Reviews for SB 431542

Average Rating: 4.8 (Based on 4 Reviews)

5 Star
25%
4 Star
8.33%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used SB 431542?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


culture
By Do-Hyun Kim on 05/23/2023
Species: Mouse

using for organoid culture. (lot#16A/281017)

Inhibition of pSmad 2/3 in a human epithelial cell line
By Anonymous on 10/26/2020
Species: Human

Tested a human lung epithelial cell line pretreated with SB431542 at either 10, 1 or 0.1uM for 30 min and then added TGFb1 at 5ng/ml in two different matrices. Incubated 24hr and then lysed cells to look at pSmad 2/3 levels by immunoassay

Inhibition of pSmad 2/3 in a human epithelial cell line 1614
3D cultures
By Anonymous on 02/06/2020
Species: Human

Worked consistently in generation of cerebral organoids from human iPS cells

3D cultures 1614
Works really well as a TGF-beta receptor Inhibitor
By Prasanna Ekambaram on 12/08/2019
Species: Human

I used it as a TGF-beta receptor Inhibitor in Breast cancer Cells to study the impact of blocking TGF-beta pathway on EMT. I used the concentration 5uM and it works really well.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.