Recombinant Mouse BAFFR/TNFRSF13C Fc Chimera Protein, CF
Recombinant Mouse BAFFR/TNFRSF13C Fc Chimera Protein, CF Summary
Product Specifications
(Catalog # 8876-BF).
| Mouse BAFF R (Ser10-Ala 71) Accession # Q9D8D0 |
DIEGRMD | Human IgG1 (Pro100-Lys330) |
| N-terminus | C-terminus | |
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
1357-BR
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: |
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Reconstitution Calculator
Background: BAFFR/TNFRSF13C
B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF ligand superfamily member and has been designated TNFSF13B. It is produced by macrophages, dendritic cells, and T lymphocytes. BAFF promotes the survival of B cells and is essential for B cell maturation (1 - 4). BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF-R selectively binds BAFF. Mouse BAFF-R cDNA encodes a 175 amino acid residue (aa) transmembrane protein with a 71 aa extracellular domain, a 21 aa transmembrane domain, and a 83 aa cytoplasmic region. A second isoform of BAFF R that has a 72 aa cytoplamic region can also be produced by alternative splicing. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cells, in resting CD4+ T cells, in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells and has profound defects in antibody mediated immune responses. Similarly, A/WySnJ mice that are defective in BAFF R intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. In contrast, BCMA- or TACI-deficient mice have no major defect in B-cell development. While the function of BCMA is not defined, TACI has been shown to control B-cell homeostasis and T-cell-independent immune responses.
- Rolink, A.G. and F. Melcher (2002) Curr. Opin. Immunol. 14:266.
- Mackay, F. and J.L. Browning (2002) Nature Reviews Immunology 2:464.
- Laabi, Y. et al. (2001) Current Biol. 11:R1013.
- Thompson, J.S. et al. (2001) Science 14:2108.
Citations for Recombinant Mouse BAFFR/TNFRSF13C Fc Chimera Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses
Nat. Immunol., 2016-10-31;0(0):.
Species: Mouse
Sample Types: Serum, Whole Cells
Applications: Bioassay, ELISA Developmet -
Splenic marginal zone granulocytes acquire an accentuated neutrophil B cell-helper phenotype in chronic lymphocytic leukemia
Cancer Res, 2016-08-03;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Functional analysis of recombinant calreticulin fragment 39-272: implications for immunobiological activities of calreticulin in health and disease.
Authors: Hong C, Qiu X, Li Y
J. Immunol., 2010-09-20;185(8):4561-9.
Species: Mouse
Sample Types:
Applications: ELISA Developmet -
BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice.
Authors: Matsushita T, Fujimoto M, Hasegawa M, Matsushita Y, Komura K, Ogawa F, Watanabe R, Takehara K, Sato S
J. Invest. Dermatol., 2007-06-21;127(12):2772-80.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo
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