Metalloproteases and Regulators
Metalloproteases are secreted (ADAMTSs, BMP-1, MMPs and Pappalysins), membrane-bound (ACEs, ADAMs, MT-MMPs and Neprilysins), or cytosolic (Insulysin and THOP1). The majority of these proteases are endopeptidases in comparison to the aminopeptidases. MMPs, ADAMs and ADAMTSs are regulated by TIMPs, which have different specificity toward different members of these families.
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Aminopeptidases
- Aminopeptidase A/ENPEP
- Aminopeptidase B/RNPEP
- Aminopeptidase Inhibitors
- Aminopeptidase LRAP/ERAP2
- Aminopeptidase N/CD13
- Aminopeptidase O/ONPEP
- Aminopeptidase P1/XPNPEP1
- Aminopeptidase P2/XPNPEP2
- Aminopeptidase PILS/ARTS1
- BLMH/Bleomycin Hydrolase
- Leucyl-cystinyl Aminopeptidase/LNPEP
- Leukotriene A4 Hydrolase/LTA4H
- Methionine Aminopeptidase
- Methionine Aminopeptidase 1/METAP1
- Methionine Aminopeptidase 1D/MAP1D
- Methionine Aminopeptidase 2/METAP2
- PA2G4
- PGPEP-1
- Puromycin-sensitive aminopeptidase/NPEPPS
- TRH-degrading Ectoenzyme/TRHDE
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Angiotensin-Converting Enzyme
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Astacins & Astacin-like
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Botulinum and Tetanus Neurotoxins (BoNT and TeNT)
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Dipeptidases and Aminoacylase
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JAB1/MPN/Mov34 Metalloprotease (JAMM) Enzymes and Regulators
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Matrix Metalloproteinases (MMPs)
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Neprilysins
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TIMPs
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Metalloprotease Regulators
- alpha 2-Macroglobulin
- alpha 2-Macroglobulin-like 1/A2ML1
- Bestatin
- ECM1
- ECM2
- EMMPRIN/CD147
- Latexin
- LGI1
- Lipocalin-2/NGAL
- MBP-1
- Synthetic Metalloprotease Inhibitors
- Papilin
- PCPE-1
- Pregnancy Zone Protein/PZP
- PRG3/MBP2
- Protease Substrates
- RARRES1
- RARRES3
- RECK
- StcE
- Testican 1/SPOCK1
- Testican 2/SPOCK2
- Testican 3/SPOCK3
- TRA-1-85/CD147
- TSPAN12
- TSPAN13
- TSPAN14
- VISTA/B7-H5/PD-1H