YC 1

Biological Activity

YC 1 is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC₅₀ = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC₅₀ = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G₁ cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. YC-1, a novel activator of platelet guanylate cyclase.
   Ko et al.
   Blood., 1994;84:4226
2. YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
   Martin et al.
   Proc.Natl.Sci.U.S.A., 2001;98:12938
3. YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells.
   Wang et al.
   J.Pharmacol.Exp.Ther., 2005;312:917
4. Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4
   Teixeira et al.
   J.Pharmacol.Exp.Ther., 2006;317:258

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