WY 14643
Chemical Name: [[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
Purity: ≥98%
Biological Activity
WY 14643 is a selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice.
Li Y, Wong K, Walsh K, Gao B, Zang M
J Biol Chem, 2013;288(15):10490-504. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
The PPARs: from orphan receptors to drug discovery.
Willson et al.
J.Med.Chem., 2000;43:527 -
Peroxisome proliferator-activated receptors in the cardiovascular system.
Bishop-Bailey
Br.J.Pharmacol., 2000;129:823 -
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ.
Forman et al.
Proc.Natl.Acad.Sci.U.S.A., 1997;94:4312
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Citations for WY 14643
The citations listed below are publications that use Tocris products. Selected citations for WY 14643 include:
12 Citations: Showing 1 - 10
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Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats.
Authors: Strand Et al.
PPAR Res 2019;2019:8047627
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Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties.
Authors: Smith Et al.
Psychopharmacology (Berl) 2019;
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Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency.
Authors: Lee Et al.
J Clin Med 2018;7
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Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury.
Authors: Neuhaus Et al.
Front Mol Neurosci 2017;10:149
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Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.
Authors: Oruqaj Et al.
Proc Natl Acad Sci U S A 2015;112:E2048
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PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings.
Authors: Puligheddu Et al.
PLoS One 2013;8:e64541
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Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis.
Authors: Rizvi Et al.
Vascul Pharmacol 2013;59:144
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Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.
Authors: Mascia Et al.
Biol Psychiatry 2011;69:633
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5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
Authors: Bumpus and Johnson
Mol Psychiatry 2011;339:886
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Rapid non-genomic regulation of Ca2+ signals and Ins secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans.
Authors: Ropero Et al.
J Endocrinol 2009;200:127
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Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic DA neurons through nuclear receptors.
Authors: Melis Et al.
J Neurosci 2008;28:13985
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Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.
Authors: Lee Et al.
Biochem J 2004;378:983
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