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WAY 170523

Catalog #: 2633 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2633/1
2633/10
WAY 170523 | CAS No. 307002-73-9 | Synthetic Metalloprotease Inhibitors
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Description: Potent and selective inhibitor of MMP-13

Chemical Name: N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide

Purity: ≥99%

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Biological Activity

WAY 170523 is a potent and selective inhibitor of MMP-13 (IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively).

Technical Data

M.Wt:
613.68
Formula:
C33H31N3O7S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
307002-73-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. �-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells.
    Jaffr? et al.
    Circulation, 2012;125:2993
  2. Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design.
    Chen et al.
    J.Am.Chem.Soc., 2000;122:9648

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