Home / mAChR M4 Modulators / VU 10010

VU 10010

Catalog #: 3141
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3141/10
3141/50
VU 10010 | CAS No. 633283-39-3 | mAChR M4 Modulators
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Description: Selective positive allosteric modulator of M4 receptors

Chemical Name: 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.

Technical Data

M.Wt:
345.85
Formula:
C17H16ClN3OS
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
633283-39-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.
    Shirey et al.
    Nat.Chem.Biol., 2008;4:42

Product Datasheets

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Citation for VU 10010

The citations listed below are publications that use Tocris products. Selected citations for VU 10010 include:

1 Citation: Showing 1 - 1

  1. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    PLoS One  2015;9:115

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