VU 0365114
Chemical Name: 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
Purity: ≥98%
Biological Activity
VU 0365114 is a selective positive allosteric modulator of M5 (EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4 receptors).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M5 PAM.
Bridges et al.
Bioorg.Med.Chem.Lett., 2010;20:558 -
Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.
Bridges et al.
Bioorg.Med.Chem.Lett., 2010;20:5617
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