VU 0365114

Catalog #: 4404 Datasheet / COA / SDS

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VU 0365114 | CAS No. 1208222-39-2 | mAChR M5 Modulators

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Description: Positive allosteric modulator of M5 receptors

Chemical Name: 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

Purity: ≥98%

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Biological Activity

VU 0365114 is a selective positive allosteric modulator of M₅ (EC₅₀ values are 2.7 μM for human M₅, and >30 μM for M₁, M₂, M₃ and M₄ receptors).

Technical Data

M.Wt:

397.35

Formula:

C₂₂H₁₄F₃NO₃

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Purity:

≥98%

Storage:

Store at RT

CAS No:

1208222-39-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Chemical lead optimization of a pan G_q mAChR M₁, M₃, M₅ positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M₅ PAM.
Bridges et al.
Bioorg.Med.Chem.Lett., 2010;20:558
Heterobiaryl and heterobiaryl ether derived M₅ positive allosteric modulators.
Bridges et al.
Bioorg.Med.Chem.Lett., 2010;20:5617

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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