VU 0238429

Catalog #: 3634 Datasheet / COA / SDS

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3634/50

VU 0238429 | CAS No. 1160247-92-6 | mAChR M5 Modulators

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Description: Selective positive allosteric modulator of M5 receptors

Chemical Name: 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin

Purity: ≥97%

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Biological Activity

VU 0238429 is a selective positive allosteric modulator of M₅ receptors (EC₅₀ values are 1.16, >30 and >30 μM at M₅, M₁ and M₃ receptors respectively). Displays no activity at M₂ and M₄ receptors.

Technical Data

M.Wt:

351.28

Formula:

C₁₇H₁₂F₃NO₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥97%

Storage:

Store at -20°C

CAS No:

1160247-92-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.
Bridges et al.
J.Med.Chem., 2009;52:3445

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