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VL 285

Catalog #: 7903 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7903/10
VL 285 | CAS No. 1448188-57-5 | VHL
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Description: VHL inhibitor

Chemical Name: (2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity: ≥97%

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Biological Activity

VL 285 is an E3 ubiquitin ligase VHL inhibitor (IC50= 340 nM). VL 285 treatment competitively reduces or reverses target protein degradation by AU-15330 and HaloPROTAC3 Degraders.

Technical Data

M.Wt:
532.66
Formula:
C29H32N4O4S
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1448188-57-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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