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Vincristine sulfate

Catalog #: 1257
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1257/10
1257/50
Vincristine sulfate | CAS No. 2068-78-2 | Microtubule Binding Compounds
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Description: Disrupts microtubules

Chemical Name: 22-Oxovincaleukoblastine

Purity: ≥96%

Product Details
Citations (9)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Vincristine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.

Technical Data

M.Wt:
923.04
Formula:
C46H56N4O10.H2SO4
Solubility:
Soluble to 100 mM in water
Purity:
≥96%
Storage:
Store at -20°C
CAS No:
2068-78-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Vincristine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Vincristine sulfate

The citations listed below are publications that use Tocris products. Selected citations for Vincristine sulfate include:

9 Citations: Showing 1 - 9

  1. Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer.
    Authors: Mabe Et al.
    J Clin Invest  2018;128:4413
  2. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther  2017;16(6):1021
  3. Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells.
    Authors: Torres Et al.
    Oncotarget  2016;7:67373
  4. MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM.
    Authors: Stojcheva Et al.
    Oncotarget  2016;7:12937
  5. Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition.
    Authors: Goldman Et al.
    Nat Commun  2015;6:6139
  6. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
    Authors: Kathawala Et al.
    Oncotarget  2015;6:510
  7. Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.
    Authors: Knutson Et al.
    PLoS One  2014;9:e111840
  8. Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study.
    Authors: Kathawala Et al.
    Mol Cancer Ther  2014;13:714
  9. Synergistic effects of oncolytic reovirus and doce. chemotherapy in prostate cancer.
    Authors: Heinemann Et al.
    Sci Rep  2011;11:221

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