Vinblastine sulfate

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro.
   Jordan et al.
   Cancer Res., 1985;45:2741
3. The chemotherapeutic agent PacT. inhibits autophagy through two distinct mechanisms that regulate apoptosis.
   Veldhoen et al.
   Oncogene, 2012;32:736
4. Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly.
   Rai and Wolf
   J.Biol.Chem., 1998;273:31131
5. Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes.
   Tsukidate et al.
   Am.J.Pathol., 1993;143:918

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