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VH 032, amine

Catalog #: 6462
1 Citation Datasheet / COA / SDS
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6462/100
VH 032, amine | CAS No. 2137142-47-1 | Degrader Building Blocks
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Description: Functionalized VHL ligand for PROTACs

Chemical Name: (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032; commonly used as a precursor to a PROTAC® that hijacks VHL as the E3 ubiquitin ligase component. Supplied with a primary amine functional handle at a position known not to significantly affect binding to VHL, for ready conjugation to a linker/target protein ligand.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
503.49
Formula:
C22H30N4O3S.2HCl
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
2137142-47-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective small molecule induced degradation of the BET bromodomain protein BRD4.
    Zengerle et al.
    ACS Chem.Biol., 2015;10:1770
  2. Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.
    Galdeano et al.
    J.Med.Chem., 2014;57:8657

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Citation for VH 032, amine

The citations listed below are publications that use Tocris products. Selected citations for VH 032, amine include:

1 Citation: Showing 1 - 1

  1. PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes.
    Authors: Smalley Et al.
    Chem.Commun.(Camb)  2020;56:4476

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