Verteporfin
Chemical Name: (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
Purity: ≥95%
Biological Activity
Verteporfin is a YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties.
Song et al.
Cancer Res., 2014;74:4170 -
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.
Liu-Chittenden et al.
Genes Dev., 2012;26:1300 -
The clinically used photosensitizer vertep. (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation.
Brodowska et al.
Exp.Eye Res., 2014;124:67
Product Datasheets
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Citations for Verteporfin
The citations listed below are publications that use Tocris products. Selected citations for Verteporfin include:
14 Citations: Showing 1 - 10
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Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers.
Authors: Ute Et al.
Exp Dermatol 2022;31:1477-1499
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Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases.
Authors: Jacob A Et al.
Int J Mol Sci 2021;22
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Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional.
Authors: Hong Wei Et al.
Nat Commun 2021;12:4566
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Sox9EGFP Defines Biliary Epithelial Heterogeneity Downstream of Yap Activity.
Authors: Adam D Et al.
Cell Mol Gastroenterol Hepatol 2021;11:1437-1462
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Derivation of trophoblast stem cells from naïve human pluripotent stem cells.
Authors: Bo Et al.
Elife 2020;9
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Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer.
Authors: Jun Et al.
Clin Cancer Res 2019;25:1070-1086
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A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells.
Authors: Jose P Et al.
Mol Cancer Res 2019;17:1735-1747
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Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.
Authors: Li Et al.
Cell 2019;179:687
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Pulmonary pericytes regulate lung morphogenesis.
Authors: Kato Et al.
Nat Commun 2018;9:2448
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Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species.
Authors: Eales
Sci Rep 2018;8(1):14358
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Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size.
Authors: Yosefzon Et al.
Mol Cell 2018;70:573
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Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.
Authors: An Et al.
Cell Rep 2018;25:702
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Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells.
Authors: Fisher Et al.
Oncotarget 2017;8:110257
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A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.
Authors: Seong Et al.
Cancer Res 2017;77:696
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