Veratridine
Chemical Name: 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
Purity: ≥98%
Biological Activity
Veratridine is a voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Purification, solubility and pKa of veratridine.
McKinney et al.
Anal.Biochem., 1986;153:33 -
Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine.
Maroto et al.
Eur.J.Pharmacol., 1994;270:331 -
Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy.
Fekete et al.
J.Neurochem., 2009;111:745 -
Cytotoxicity of amide-linked local anesthetics on melanoma cells via inhibition of Ras and RhoA signaling independent of sodium channel blockade
Q Zheng, X Peng, Y Zhang
BMC Anesthesiol, 2020;20(1):43.
Product Datasheets
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Citations for Veratridine
The citations listed below are publications that use Tocris products. Selected citations for Veratridine include:
6 Citations: Showing 1 - 6
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Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
Authors: Agarwal Et al.
Neuron 2017;93:587
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An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
Authors: McKeithan Et al.
Front Physiol 2017;8:766
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Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity.
Authors: Battefeld Et al.
Biol Psychiatry 2016;7:11298
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High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes.
Authors: Bedut Et al.
Am J Physiol Heart Circ Physiol 2016;311:H44
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Human macrophage SCN5A activates an innate immune signaling pathway for antiviral host defense.
Authors: Jones Et al.
J Biol Chem 2014;289:35326
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Neural progenitors organize in small-world networks to promote cell proliferation.
Authors: Malmersjö Et al.
Nat Commun 2013;110:E1524
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