Urolithin A

Catalog #: 6762 Datasheet / COA / SDS

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Urolithin A | CAS No. 1143-70-0 | PI 3-Kinase Inhibitors

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Description: PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Chemical Name: 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one

Purity: ≥98%

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Biological Activity

Urolithin A is a PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell lines in vitro (IC₅₀ values are 10.23 - 62.28 μM). Suppresses tumor growth and improves survival in mice bearing pancreatic tumor xenografts. Also blocks amyloid-β fibrillation in vitro.

Technical Data

M.Wt:

228.2

Formula:

C₁₃H₈O₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1143-70-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer.
Totiger et al.
Mol.Cancer Ther., 2019;18:301
Pomegranate's neuroprotective effects against Alzheimer's disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites.
Yuan et al.
ACS Chem.Neurosci., 2016;7:26

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