uPSEM 792 hydrochloride
Chemical Name: 1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride
Purity: ≥98%
Biological Activity
uPSEM 792 hydrochloride is a ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over α7-GlyR, α7-5HT3, and 5HT3-R, and 230-fold selectivity over α4β2 nAChR. Also weak partial agonist (~10 %) at α4β2 nAChR. Retains the potency of varenicline (Cat.No. 3754) for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.
Background References
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Ultrapotent chemogenetics for research and potential clinical applications.
Magnus et al.
Science, 2019;
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Citations for uPSEM 792 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for uPSEM 792 hydrochloride include:
3 Citations: Showing 1 - 3
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Neocortical synaptic engrams for remote contextual memories.
Authors: Ji-Hye Et al.
Nat Neurosci 2023;26:259-273
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A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons
Authors: Perez-Sanchez Et al.
Sci.Transl.Med 2023;15:eadh3839
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Extrinsic control and intrinsic computation in the hippocampal CA1 circuit.
Authors: Manuel Et al.
Neuron 2022;110:658-673.e5
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