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Universal Type I IFN Protein

Catalog #: 11200-2
31 Citations 1 Review Datasheet / COA / SDS
(Recombinant Human IFN-alpha A/D [BglII])
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11200-2
R&D Systems Recombinant Proteins and Enzymes
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Citations (31)
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Universal Type I IFN Protein Summary

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11200-2

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11200-2

Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
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Background: IFN-alpha

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Long Name
Interferon alpha
Entrez Gene IDs
3440 (Human)
Alternate Names
IFNA; IFNA2; IFNA2b; IFNalpha; IFN-alpha; IFN-alphaA; INFA2; interferon alpha 2; LeIF D

Citations for Universal Type I IFN Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

31 Citations: Showing 1 - 10
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  1. APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1
    Authors: Ikeda, T;Shimizu, R;Nasser, H;Carpenter, MA;Cheng, AZ;Brown, WL;Sauter, D;Harris, RS;
    mBio
    Species: Human
    Sample Types: Transduced Whole Cells
    Applications: Bioassay
  2. LRRC15 inhibits SARS-CoV-2 cellular entry in trans
    Authors: J Song, RD Chow, M Pena-Herna, L Zhang, SA Loeb, EY So, OD Liang, P Ren, S Chen, CB Wilen, S Lee
    PloS Biology, 2022-10-13;20(10):e3001805.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication
    Authors: B Los, M Preu beta ner, K Eschke, RM Vidal, A Abdelgawad, D Olofsson, S Keiper, M Paulo-Pedr, A Grindel, S Meinke, J Trimpert, F Heyd
    Nucleic Acids Research, 2022-07-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat
    Authors: X Yang, X Zhao, Y Zhu, Y Shen, Y Wang, P Lu, Z Jiang, H Pan, J Yang, J Xun, L Zhao, J Wang, Z Liang, X Shen, Y Liang, Q Lin, H Liang, L Jin, D Zhang, J Liu, B Wang, S Jiang, J Xu, H Wu, H Lu, H Zhu
    MBio, 2021-07-20;0(0):e0079521.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus
    Authors: N Buang, L Tapeng, V Gray, A Sardini, C Whilding, L Lightstone, TD Cairns, MC Pickering, J Behmoaras, GS Ling, M Botto
    Nature Communications, 2021-03-31;12(1):1980.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B co-infection
    Authors: KP Singh, JM Zerbato, W Zhao, S Braat, C Deleage, GS Tennakoon, H Mason, A Dantanaray, A Rhodes, JW Rhodes, J Torresi, AN Harman, PA Revill, M Crane, JD Estes, A Avihingsan, SR Lewin, J Audsley
    PLoS Pathog., 2020-09-08;16(9):e1008744.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1
    Authors: C Paulus, T Harwardt, B Walter, A Marxreiter, M Zenger, E Reuschel, MM Nevels
    PLoS Pathog., 2020-05-04;16(5):e1008537.
    Species: Human
    Sample Types:
    Applications: Cell Culture
  8. Diverse effects of interferon alpha on the establishment and reversal of HIV latency
    Authors: RM Van der Sl, JM Zerbato, JW Rhodes, RD Pascoe, A Solomon, NA Kumar, AI Dantanaray, S Tennakoon, J Dufloo, J McMahon, JJ Chang, VA Evans, PJ Hertzog, MR Jakobsen, AN Harman, SR Lewin, PU Cameron
    PLoS Pathog., 2020-02-28;16(2):e1008151.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. The Phenotype and Secretory Activity of Adipose-Derived Mesenchymal Stem Cells (ASCs) of Patients with Rheumatic Diseases
    Authors: E Kuca-Warna, U Skalska, I Janicka, U Musia?owic, K Bonek, P G?uszko, P Szcz?sny, M Olesi?ska, E Kontny
    Cells, 2019-12-17;8(12):.
    Species: Human
    Sample Types:
    Applications: Cell Culture
  10. IL-15 and IFN-? signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling
    Authors: F Vahedi, AJ Lee, SE Collins, MV Chew, E Lusty, B Chen, A Dubey, CD Richards, JJ Feld, RS Russell, KL Mossman, AA Ashkar
    Cytokine, 2018-06-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus
    Authors: K Matsuno, M Kajihara, R Nakao, N Nao, A Mori-Kajih, M Muramatsu, Y Qiu, S Torii, M Igarashi, N Kasajima, K Mizuma, K Yoshii, H Sawa, C Sugimoto, A Takada, H Ebihara
    mSphere, 2018-06-13;3(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
    Authors: U Cytlak, A Resteu, D Bogaert, HS Kuehn, T Altmann, A Gennery, G Jackson, A Kumanovics, KV Voelkerdin, S Prader, M Dullaers, J Reichenbac, H Hill, F Haerynck, SD Rosenzweig, M Collin, V Bigley
    Nat Commun, 2018-03-27;9(1):1239.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Epidermal keratinocytes sense dsRNA via the NLRP3 inflammasome, mediating interleukin (IL)-1? and IL-18 release
    Authors: X Dai, M Tohyama, M Murakami, K Sayama
    Exp. Dermatol, 2017-05-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Type I IFN counters or promotes Coxiella burnetii replication dependent on tissue
    Authors: JF Hedges, A Robison, E Kimmel, K Christense, E Lucas, A Ramstead, MA Jutila
    Infect Immun, 2016-05-24;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  15. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
    Nature, 2016-05-18;533(7604):493-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. ATF3 Is a Key Regulator of Macrophage IFN Responses.
    Authors: Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D
    J Immunol, 2015-09-28;195(9):4446-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Annexin V incorporated into influenza virus particles inhibits gamma interferon signaling and promotes viral replication.
    Authors: Berri F, Haffar G, Le V, Sadewasser A, Paki K, Lina B, Wolff T, Riteau B
    J Virol, 2014-07-16;88(19):11215-28.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. An innate immunity-regulating virulence determinant is uniquely encoded by the Andes virus nucleocapsid protein.
    Authors: Cimica V, Dalrymple N, Roth E, Nasonov A, Mackow E
    MBio, 2014-02-18;5(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib.
    Authors: Ray A, Tian Z, Das D, Coffman R, Richardson P, Chauhan D, Anderson K
    Leukemia, 2014-01-30;28(8):1716-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness.
    Authors: Li X, Jiang L, Chen L, Ding M, Guo H, Zhang W, Zhang H, Ma X, Liu X, Xi X, Chen S, Chen Z, Zhu J
    Mol Cell, 2014-01-09;53(3):407-19.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18.
    Authors: Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H
    PLoS ONE, 2013-12-20;8(12):e82586.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway.
    Authors: Wang T, Ge Y, Xiao M, Lopez-Coral A, Li L, Roesch A, Huang C, Alexander P, Vogt T, Xu X, Hwang W, Lieu M, Belser E, Liu R, Somasundaram R, Herlyn M, Kaufman R
    J Invest Dermatol, 2013-10-24;134(4):1108-18.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus.
    Authors: Webster, Brian, Ott, Melanie, Greene, Warner C
    J Virol, 2013-10-02;87(24):13354-69.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway.
    Authors: Chen, Qian, Swaminathan, Sanjay, Yang, De, Dai, Lue, Sui, Hongyan, Yang, Jun, Hornung, Ronald L, Wang, Yanmei, Huang, Da Wei, Hu, Xiaojun, Lempicki, Richard, Imamichi, Tomozumi
    PLoS ONE, 2013-03-20;8(3):e59194.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis.
    Authors: Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S
    J Immunol, 2013-03-18;190(8):3959-66.
    Species: Human
    Sample Types: Plasma
    Applications: Bioassay
  26. Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
    Authors: Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R
    Clin Cancer Res, 2013-02-26;19(7):1858-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1).
    Authors: Jones P, Maric M, Madison M, Maury W, Roller R, Okeoma C
    Virology, 2013-02-12;438(1):37-49.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012-07-26;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival.
    Authors: Cilloniz C, Pantin-Jackwood MJ, Ni C, Carter VS, Korth MJ, Swayne DE, Tumpey TM, Katze MG
    J. Virol., 2011-12-21;86(5):2437-46.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  30. Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma.
    Authors: Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C
    PLoS Pathog., 2011-04-14;7(4):e1002016.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
    Authors: Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S
    J. Exp. Med., 2008-12-29;206(1):249-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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Universal Type I IFN Protein
By Anonymous on 07/05/2024
Application: CellProlif