Home / Apoptosis Inducer Compounds / UC 112

UC 112

Catalog #: 5251
1 Citation Datasheet / COA / SDS

Discontinued Product

5251 has been discontinued.
View all Apoptosis Inducer Compounds products.
UC 112 | CAS No. 383392-66-3 | Apoptosis Inducer Compounds
1 Image
Description: IAP and XIAP inhibitor; antitumor

Chemical Name: 5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

UC 112 is an iAP inhibitor (IC50 values from 0.7 - 3.4 μM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.

Technical Data

M.Wt:
348.44
Formula:
C22H24N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
383392-66-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for UC 112

The citations listed below are publications that use Tocris products. Selected citations for UC 112 include:

1 Citation: Showing 1 - 1

  1. A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins
    Authors: Schwalm Et al.
    Front.Cell.Dev.Biol.  2022;10:886537

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for UC 112

There are currently no reviews for this product. Be the first to review UC 112 and earn rewards!

Have you used UC 112?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.