TRO 19622
Chemical Name: Cholest-4-en-3-one oxime
Purity: ≥98%
Biological Activity
TRO 19622 is a neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.
Bordet et al.
J.Pharmacol.Exp.Ther., 2007;322:709
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Citations for TRO 19622
The citations listed below are publications that use Tocris products. Selected citations for TRO 19622 include:
2 Citations: Showing 1 - 2
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Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies.
Authors: González Et al.
Front Neurosci 2016;126:1023
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Bacterial RTX toxins allow acute ATP release from human erythrocytes directly through the toxin pore.
Authors: Skals Et al.
J Biol Chem 2014;289:19098
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