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tri-GalNAc biotin

Catalog #: 7635 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7635/50U
tri-GalNAc biotin | Degrader Building Blocks
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Description: Biotinylated ASGPR ligand for LYTAC research and development

Purity: ≥90%

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Biological Activity

Tri-GalNAc-biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development, comprising a triantennary N-acetylgalactosamine (GalNAc) joined by a PEG linker to biotin. Tri-GalNAc-biotin can induce ASGPR-mediated endocytosis and trafficking of fluorescently labeled neutravidin for lysosomal degradation in HepG2 cells in a time-dependent manner. The increase in fluorescent signal within cells plateaus after 16-20h, and this effect can be inhibited by addition of tri-GalNAc COOH (Cat. No. 7401).

Technical Data

M.Wt:
1916.21
Formula:
C83H146N14O34S
Solubility:
Soluble to 50 mM in water
Purity:
≥90%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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