TPCA-1

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. A highly conserved NF-kappaB-responsive enhancer is critical for thymic expression of Aire in mice.
   Haljasorg U, Bichele R, Saare M, Guha M, Maslovskaja J, Kond K, Remm A, Pihlap M, Tomson L, Kisand K, Laan M, Peterson P
   Eur J Immunol, 2015;45(12):3246-56.
2. Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNF? and co-treatments
   LH Loo, NM Bougen-Zhu, WC Tan
   Sci Rep, 2017;7(0):43541.
3. NF-kappaB and STAT1 control CXCL1 and CXCL2 gene transcription.
   Burke S, Lu D, Sparer T, Masi T, Goff M, Karlstad M, Collier J
   Am J Physiol Endocrinol Metab, 2014;306(2):E131-49.
4. Regulation of the CCL2 Gene in Pancreatic beta-Cells by IL-1beta and Glucocorticoids: Role of MKP-1.
   Burke S, Goff M, Updegraff B, Lu D, Brown P, Minkin S, Biggerstaff J, Zhao L, Karlstad M, Collier J
   PLoS ONE, 2012;7(10):e46986.
5. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IκB kinase 2, TPCA-1 (2-[aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and
   Podolin et al.
   J.Pharmacol.Exp.Ther., 2005;312:373
6. IK-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma.
   Birrell et al.
   Am.J.Respir.Crit.Care Med., 2005;172:962
7. IκB kinase-2-independent and-dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic.
   Birrell et al.
   Mol.Pharmacol., 2006;69:1791
8. CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic Malignancies
   A Rodriguez-, P Sharma, M Poussin, AC Boesteanu, NG Minutolo, SB Gitto, DK Omran, MK Robinson, GP Adams, F Simpkins, DJ Powell
   Mol. Ther., 2019;0(0):.
9. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer
   J O'Connell, J Porter, B Kroeplien, T Norman, S Rapecki, R Davis, D McMillan, T Arakaki, A Burgin, D Fox Iii, T Ceska, F Lecomte, A Maloney, A Vugler, B Carrington, BP Cossins, T Bourne, A Lawson
   Nat Commun, 2019;10(1):5795.
10. Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-kappaB-driven inflammation through redox-active mechanisms
    SC Koeberle, A Gollowitze, J Laoukili, O Kranenburg, O Werz, A Koeberle, AP Kipp
    Redox Biol, 2019;28(0):101388.

Product Datasheets