Toyocamycin
Chemical Name: 4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Purity: ≥98%
Biological Activity
Toyocamycin is an adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.
Ri et al.
Blood.Cancer.J., 2012;2:e79 -
Inhibition of phosphatidylinositol kinase by toyocamycin.
Nishioka et al.
J.Antibiot. (Tokyo)., 1990;43:1586 -
Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
Yen et al.
RNA, 2006;12:797
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Citation for Toyocamycin
The citations listed below are publications that use Tocris products. Selected citations for Toyocamycin include:
1 Citation: Showing 1 - 1
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IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma.
Authors: Tanabe Et al.
Oncotarget 2018;9:14428
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