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Torin 1

Catalog #: 4247
249 Citations Datasheet / COA / SDS
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4247/50
Torin 1 | CAS No. 1222998-36-8 | mTOR Inhibitors
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Description: Potent and selective mTOR inhibitor

Chemical Name: 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one

Purity: ≥98%

Product Details
Citations (249)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Torin 1 is a potent and selective ATP-competitive mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin 1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. In HeLa cells, Torin 1 induces autophagy. Torin 1 impairs cell growth and proliferation by suppression of the rapamycin-resistant functions of mTORC1. In human monocytes and myeloid dendritic cells, Torin 1 prevents decreases the anti-inflammatory potency of glucocorticoids. In the human endocrine cell line BON, Torin 1 increases neurotensin secretion and gene expression through MEK/ERK/c-Jun pathway activation.

Technical Data

M.Wt:
607.62
Formula:
C35H28F3N5O2
Solubility:
Soluble to 1 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1222998-36-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Whitehead Institute for Biomedical Research.

Background References

  1. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
    Thoreen CC, Kang SA, Chang JW et al.
    J Biol Chem
  2. Keap1 degradation by autophagy for the maintenance of redox homeostasis.
    Taguchi, Keiko, Fujikawa, Nanako, Komatsu, Masaaki, Ishii, Tetsuro, Unno, Michiaki, Akaike, Takaaki, Motohashi, Hozumi, Yamamoto, Masayuki
    Proc Natl Acad Sci U S A, 2012;109(34):13561-6.
  3. Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
    G Figlia, C Norrmén, JA Pereira, D Gerber, U Suter
    Elife, 2017;6(0):.
  4. Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation.
    Shi Y, Chen J, Karner C, Long F
    Proc Natl Acad Sci U S A, 2015;112(15):4678-83.
  5. Multistep regulation of TFEB by MTORC1
    S Vega-Rubin, S Pe¤a-Llopi, M Konda, J Brugarolas
    Autophagy, 2017;0(0):0.
  6. mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci
    I Kelsey, M Zbinden, V Byles, M Torrence, BD Manning
    Sci Rep, 2017;7(1):16112.
  7. Immunometabolic Pathways in BCG-Induced Trained Immunity

    Cell Rep, 2016;17(10):2562-2571.
  8. The cerebral cavernous malformation 3 gene is necessary for senescence induction.
    Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, Zalvide J
    Aging Cell, 2015;14(2):274-83.
  9. ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction
    JM Park, M Seo, CH Jung, D Grunwald, M Stone, NM Otto, E Toso, Y Ahn, M Kyba, TJ Griffin, L Higgins, DH Kim
    Autophagy, 2018;0(0):1-28.
  10. The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization.
    Ando R, Shima H, Tamahara T, Sato Y, Watanabe-Matsui M, Kato H, Sax N, Motohashi H, Taguchi K, Yamamoto M, Nio M, Maeda T, Ochiai K, Muto A, Igarashi K
    J Biol Chem, 2016;291(4):1826-40.
  11. A? accumulation causes MVB enlargement and is modelled by dominant negative VPS4A
    K Willén, JR Edgar, T Hasegawa, N Tanaka, CE Futter, GK Gouras
    Mol Neurodegener, 2017;12(1):61.
  12. Penehyclidine effects the angiogenic potential of pulmonary microvascular endothelial cells
    P Xie, Z Zheng, L Jiang, S Wu
    Pulm Pharmacol Ther, 2019;0(0):.
  13. Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF.
    Bernard M, Dieude M, Yang B, Hamelin K, Underwood K, Hebert M
    Autophagy, 2014;10(12):2193-207.
  14. Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells
    M Mauro-Lizc, A López-Riva
    Cell Death Dis, 2018;9(2):205.
  15. Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9
    JA Schwartz, KL Clayton, S Mujib, H Zhang, AK Rahman, J Liu, FY Yue, E Benko, C Kovacs, MA Ostrowski
    J. Immunol, 2017;0(0):.
  16. Signaling mechanisms that suppress the cytostatic actions of rapamycin.
    Jahn S, Law M, Corsino P, Davis B, Harrison J, Law B
    PLoS ONE, 2014;9(6):e99927.
  17. Establishment and Characterization of a Pair of Patient-derived Human Non-small Cell Lung Cancer Cell Lines from a Primary Tumor and Corresponding Lymph Node Metastasis
    F Gebauer, D Wicklein, M Tachezy, T Grob, D Steinemann, G Manukjan, G Göhring, B Schlegelbe, H Maar, JR Izbicki, M Bockhorn, U Schumacher
    Anticancer Res, 2016;36(4):1507-18.
  18. Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons.
    Li, I-Hsun, Ma, Kuo-Hsin, Weng, Shao-Ju, Huang, Shiang-S, Liang, Chang-Mi, Huang, Yuahn-Si
    PLoS ONE, 2014;9(12):e116565.
  19. Interferon-gamma regulates cellular metabolism and mRNA translation to potentiate macrophage activation.
    Su X, Yu Y, Zhong Y, Giannopoulou E, Hu X, Liu H, Cross J, Ratsch G, Rice C, Ivashkiv L
    Nat Immunol, 2015;16(8):838-49.
  20. Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism
    Li He
    J Leukoc Biol, 2016;0(0):.
  21. Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.
    Tholen M, Wolanski J, Stolze B, Chiabudini M, Gajda M, Bronsert P, Stickeler E, Rospert S, Reinheckel T
    J Biol Chem, 2015;290(25):15758-69.
  22. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;
  23. The pharmacology of mTOR inhibition.
    Guertin and Sabatini
    Sci.Signal., 2009;2:pe24
  24. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
    Peterson et al.
    Cell., 2011;146:408
  25. Discovery of 1-(4(-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.
    Liu et al.
    J.Med.Chem., 2010;53:7146

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Citations for Torin 1

The citations listed below are publications that use Tocris products. Selected citations for Torin 1 include:

249 Citations: Showing 1 - 10

  1. A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.
    Authors: Yumei Et al.
    Mol Cell  2023;83:57-73.e9
  2. TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.
    Authors: Atsushi Et al.
    JCI Insight  2023;8
  3. TFEB-dependent lysosome biogenesis is required for senescence.
    Authors: Rachel Et al.
    EMBO J  2023;42:e111241
  4. Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix.
    Authors: Sandra L Et al.
    iScience  2023;26:105965
  5. Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition.
    Authors: Markus Et al.
    Int J Mol Sci  2023;24
  6. RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome.
    Authors: Giancarlo Et al.
    Nat Commun  2023;14:2775
  7. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
    Authors: Wendy H Et al.
    Acta Neuropathol  2023;145:749-772
  8. Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
    Authors: Philip G Et al.
    Life Sci Alliance  2022;5
  9. LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function.
    Authors: Yan Et al.
    EMBO J  2022;41:e108119
  10. Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
    Authors: Jing Et al.
    Cell Rep  2022;40:111092
  11. Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex.
    Authors: Chin-Lee Et al.
    iScience  2022;25:105458
  12. Measuring Autophagic Cargo Flux with Keima-Based Probes.
    Authors: Lisa B Et al.
    Methods Mol Biol  2022;2445:99-115
  13. Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins.
    Authors: Koji L Et al.
    EMBO Rep  2022;23:e54801
  14. The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3.
    Authors: Jose A Et al.
    Autophagy  2022;18:2333-2349
  15. SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
    Authors: Joo-Yeon Et al.
    Autophagy  2022;18:1613-1628
  16. Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy.
    Authors: Florian A Et al.
    Autophagy  2022;18:1486-1502
  17. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy.
    Authors: Catherine Et al.
    Brain  2022;145:4368-4384
  18. Targeting of Ubiquitin E3 Ligase RNF5 as a Novel Therapeutic Strategy in Neuroectodermal Tumors.
    Authors: Alessandra Et al.
    Cancers (Basel)  2022;14
  19. SETD2 transcriptional control of ATG14L/S isoforms regulates autophagosome-lysosome fusion.
    Authors: Daniel J Et al.
    Cell Death Dis  2022;13:953
  20. mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1.
    Authors: Florian Et al.
    Nat Commun  2022;13:4685
  21. Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
    Authors: Keith Et al.
    Nat Commun  2022;13:4146
  22. A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress.
    Authors: Devrim Et al.
    Sci Rep  2022;12:8134
  23. Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner.
    Authors: Xinyi Et al.
    FEBS Open Bio  2022;12:118-129
  24. Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells.
    Authors: Frank Et al.
    Metabolites  2022;12
  25. 3D chromatin remodeling potentiates transcriptional programs driving cell invasion.
    Authors: Adriana Et al.
    Proc Natl Acad Sci U S A  2022;119:e2203452119
  26. A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag.
    Authors: Noboru Et al.
    Elife  2022;11
  27. Local anesthetics elicit immune-dependent anticancer effects.
    Authors: Peter Et al.
    J Immunother Cancer  2022;10
  28. Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.
    Authors: Jing Et al.
    Mol Cell  2021;81:4191-4208.e8
  29. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.
    Authors: John M Et al.
    Mol Cell  2021;81:2076-2093.e9
  30. mTORC1 promotes cell growth via m6A-dependent mRNA degradation.
    Authors: Joshua D Et al.
    Mol Cell  2021;81:2064-2075.e8
  31. Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals.
    Authors: Qiong Et al.
    Sci Immunol  2021;6
  32. p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway.
    Authors: Markus Et al.
    Cell Stress  2021;5:176-182
  33. FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62.
    Authors: Päivi Et al.
    Mol Neurobiol  2021;58:5438-5458
  34. Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.
    Authors: Paul F Et al.
    Dev Cell  2021;56:811-825.e6
  35. NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
    Authors: Roberto Et al.
    Dev Cell  2021;56:260-276.e7
  36. Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.
    Authors: David C Et al.
    Dev Cell  2021;56:1961-1975.e5
  37. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
    Authors: John M Et al.
    Mol Metab  2021;53:101309
  38. Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway.
    Authors: Neysan Et al.
    Commun Biol  2021;4:831
  39. The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction.
    Authors: Carolyn Et al.
    Nucleic Acids Res  2021;49:458-478
  40. mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.
    Authors: An-Dao Et al.
    Nucleic Acids Res  2021;49:3461-3489
  41. Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease.
    Authors: Andrew Et al.
    Cell Rep  2021;36:109636
  42. Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells.
    Authors: Michael Et al.
    FASEB J  2021;35:e21909
  43. Increased fidelity of protein synthesis extends lifespan.
    Authors: Mario Et al.
    Cell Metab  2021;33:2288-2300.e12
  44. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
    Authors: Costas A Et al.
    Cell Metab  2021;33:1013-1026.e6
  45. pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells.
    Authors: Torsten Et al.
    Mol Biol Cell  2021;32:131-142
  46. Development of a specific live-cell assay for native autophagic flux.
    Authors: Sami J Et al.
    J Biol Chem  2021;297:101003
  47. Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade.
    Authors: Guido Et al.
    Cell Death Differ  2021;28:1733-1752
  48. Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex.
    Authors: Anne-Claude Et al.
    J Cell Biol  2021;220
  49. Genistein Activates Transcription Factor EB and Corrects Niemann-Pick C Phenotype.
    Authors: Juan Et al.
    Int J Mol Sci  2021;22
  50. Impaired TRIM16-Mediated Lysophagy in Chronic Obstructive Pulmonary Disease Pathogenesis.
    Authors: Jun Et al.
    J Immunol  2021;207:65-76
  51. Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells.
    Authors: Selim Et al.
    Int J Med Sci  2021;18:137-149
  52. TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium.
    Authors: Sung Hoon Et al.
    Autophagy  2021;17:761-778
  53. Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response.
    Authors: Joel D Et al.
    Autophagy  2021;17:3740-3752
  54. A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway.
    Authors: Hanna Et al.
    Autophagy  2021;17:3124-3139
  55. The DNA methyltransferase DNMT3A contributes to autophagy long-term memory.
    Authors: Michael G Et al.
    Autophagy  2021;17:1259-1277
  56. Generation of mouse-human chimeric embryos.
    Authors: Boyang Et al.
    Nat Protoc  2021;16:3954-3980
  57. Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response.
    Authors: Mathilde Et al.
    Mol Brain  2021;14:87
  58. Evidence for Lysosomal Dysfunction within the Epidermis in Psoriasis and Atopic Dermatitis.
    Authors: Hans-Uwe Et al.
    J Invest Dermatol  2021;141:2838-2848.e4
  59. Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence.
    Authors: M Et al.
    Nat Commun  2021;12:5507
  60. Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis.
    Authors: Shuang Et al.
    Nat Commun  2021;12:5214
  61. Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24.
    Authors: Yang Et al.
    Nat Commun  2021;12:508
  62. NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
    Authors: Koji L Et al.
    Nat Commun  2021;12:3292
  63. Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis.
    Authors: Konstantinos Et al.
    Nat Commun  2021;12:2424
  64. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
    Authors: John M Et al.
    Elife  2021;10
  65. 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis.
    Authors: Steven P Et al.
    Mol Cell  2020;80:828-844.e6
  66. Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos.
    Authors: Jingxin Et al.
    Sci Adv  2020;6:eaaz0298
  67. A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
    Authors: Pier Paolo Et al.
    Nature  2020;585:597-602
  68. Decoy exosomes provide protection against bacterial toxins.
    Authors: Derya Et al.
    Nature  2020;579:260-264
  69. Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment.
    Authors: Jun Et al.
    EMBO J  2020;39:e103790
  70. mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR.
    Authors: David C Et al.
    Cell Rep  2020;33:108564
  71. CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci.
    Authors: Ignacio Et al.
    Cell Rep  2020;33:108545
  72. Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation.
    Authors: Anne Et al.
    Cell Rep  2020;32:108154
  73. BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells.
    Authors: Christopher J Et al.
    Cell Rep  2020;31:107474
  74. The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1.
    Authors: Jürg Et al.
    Cell Rep  2020;30:3240-3249.e4
  75. Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition.
    Authors: Jurre J Et al.
    Cell Rep  2020;30:2729-2742.e4
  76. Von Hippel-Lindau tumor suppressor (VHL) stimulates TOR signaling by interacting with phosphoinositide 3-kinase (PI3K).
    Authors: Wonho Et al.
    J Biol Chem  2020;295:2336-2347
  77. The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases.
    Authors: Cosima T Et al.
    Cell Death Differ  2020;27:310-328
  78. Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
    Authors: Satoru Et al.
    Nat Struct Mol Biol  2020;27:1194-1201
  79. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.
    Authors: Chen Et al.
    Nat Cell Biol  2020;22:246-256
  80. Effects of mTOR inhibitors on neuropathic pain revealed by optical imaging of the insular cortex in rats.
    Authors: Bae Hwan Et al.
    Brain Res  2020;1733:146720
  81. Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.
    Authors: Yan Et al.
    Autophagy  2020;16:1683-1696
  82. De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy.
    Authors: Vladimir Et al.
    Autophagy  2020;16:1044-1060
  83. MITF and TFEB cross-regulation in melanoma cells.
    Authors: Valerie Et al.
    PLoS One  2020;15:e0238546
  84. The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling.
    Authors: Jing Et al.
    J Cell Sci  2020;133
  85. Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
    Authors: JoAnn Et al.
    Nat Commun  2020;11:6088
  86. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.
    Authors: Florian Et al.
    Nat Commun  2020;11:5133
  87. Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy.
    Authors: Guido Et al.
    Cell Death Dis  2020;11:433
  88. Macropinocytosis drives T cell growth by sustaining the activation of mTORC1.
    Authors: Di Et al.
    Nat Commun  2020;11:180
  89. Microglial metabolic flexibility supports immune surveillance of the brain parenchyma.
    Authors: Louis-Philippe Et al.
    Nat Commun  2020;11:1559
  90. Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.
    Authors: Sang Gyun Et al.
    Nat Commun  2020;11:1416
  91. Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing.
    Authors: Asma Et al.
    Proc Natl Acad Sci U S A  2020;117:9477-9482
  92. The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling.
    Authors: Jing Et al.
    J Cell Sci  2020;
  93. HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
    Authors: Neubert Et al.
    Autophagy  2019;:1
  94. Lysophosphatidic acid represses autophagy in prostate carcinoma cells.
    Authors: Roberto J Et al.
    Biochem Cell Biol  2019;97:387-396
  95. Mammalian cell growth dynamics in mitosis.
    Authors: Scott R Et al.
    Elife  2019;8
  96. Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity.
    Authors: Seyed Mehdi Et al.
    Cell Rep  2019;29:3620-3635.e7
  97. The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress.
    Authors: Andreas Et al.
    J Biol Chem  2019;294:8197-8217
  98. NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression.
    Authors: Masaya Et al.
    Cell Rep  2019;28:1282-1295.e8
  99. Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.
    Authors: Sica Et al.
    Cell Rep  2019;27:820
  100. Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β-cells.
    Authors: Ji Et al.
    J Cell Mol Med  2019;23:2890
  101. ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
    Authors: Daniel S Et al.
    Nat Cell Biol  2019;21:1206-1218
  102. Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis.
    Authors: Jun Et al.
    J Immunol  2019;202:1428-1440
  103. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition.
    Authors: Charles A Et al.
    Nat Chem Biol  2019;15:776-785
  104. MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress.
    Authors: Arzu Et al.
    Autophagy  2019;15:375-390
  105. Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.
    Authors: Hua Et al.
    Autophagy  2019;15:1954-1969
  106. TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy.
    Authors: Andrea Et al.
    Autophagy  2019;15:151-164
  107. VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
    Authors: Conrad C Et al.
    Autophagy  2019;15:1082-1099
  108. Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model.
    Authors: Dong-Hyung Et al.
    Cell Death Dis  2019;10:952
  109. Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis.
    Authors: Lambelet Et al.
    Cell Death Dis  2018;9:96
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  116. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.
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  117. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.
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    Cancer Cell  2018;34:85
  118. Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.
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    Cell Rep  2018;25:2878
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    Autophagy  2018;14:1586
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  133. TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.
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    Cancer Res  2017;77:5077
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    Mol Cell  2017;65:999
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    Dev Cell  2017;43:673-688.e5
  141. DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.
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    Dev Cell  2017;42:9
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    J Immunol  2017;198:3181
  144. TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
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    EMBO Rep  2017;18:2197
  145. Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation.
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    Mol Cancer Res  2017;15:117
  146. Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.
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    PLoS Pathog  2017;13:e1006635
  147. The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
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    Autophagy  2017;13:2041
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    Curr Protoc Chem Biol  2016;8:225-233
  151. The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport.
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    Oncotarget  2016;7:86871
  152. TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress.
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    Oncotarget  2016;7:85365
  153. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
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    Oncotarget  2016;7:20016
  154. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
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    Nature Communications  2016;7:13130
  155. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.
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    Nat Commun  2016;7:11127
  156. mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
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    Mol Biol Cell  2016;7:10786
  157. Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway.
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    PLoS One  2016;6:28423
  158. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
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    Nature  2016;539:390
  159. An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK.
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    Proc Natl Acad Sci U S A  2016;5
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  161. Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.
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    Oncogene  2016;35:1250
  162. TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.
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  166. Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation.
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    J Biol Chem  2016;291:10772-82
  167. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells.
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  168. nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.
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    Genome Res  2016;26:636
  169. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis.
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    J Immunol  2016;197:504
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  177. IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells.
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  183. The MAPK and PI3K pathways mediate CNTF-induced neuronal survival and process outgrowth in hypothalamic organotypic cultures.
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    Mol Cancer Res  2015;8:ra34
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    Neuron  2015;85:303
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    Cell Death Dis  2015;6:e1880
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    Nat Commun  2015;6:8048
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    Autophagy  2015;67:966
  191. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
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    Autophagy  2015;519:477
  192. Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1.
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  193. Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy.
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    Mol Cell Biol  2015;35:2479
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    J Biol Chem  2015;290:9571-87
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    J Biol Chem  2015;290:15996
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  205. mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation.
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    Cell Rep  2015;12:102
  206. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis.
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  211. mTORC2 regulates cardiac response to stress by inhibiting MST1.
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    Elife  2015;11:125
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  213. Hedgehog signaling activates a positive feedback mechanism involving Ins-like growth factors to induce osteoblast differentiation.
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    Sci Signal  2014;7:ra9
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    Dis Model Mech  2014;7:63
  219. Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway.
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    Diabetes  2014;63:3404
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    J Exp Med  2014;211:2249
  221. OE and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.
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    BMC Biochem  2014;211:15
  222. Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages.
    Authors: Zullo Et al.
    Proc Natl Acad Sci U S A  2014;15:4
  223. An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway.
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    PLoS Pathog  2014;10:e1004196
  224. Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions.
    Authors: Viktor I Et al.
    PLoS Comput Biol  2014;10:e1003728
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    PLoS Genet  2014;10:901
  226. Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids.
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    Autophagy  2014;10:431
  227. Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF.
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    Cell Cycle  2014;10:2193
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    Arthritis Rheumatol  2014;10:1637
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    Autophagy  2013;9:1418
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  232. Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.
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    Diabetes  2013;62:1227
  233. Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.
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    J Lipid Res  2013;54:1662
  234. Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.
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    Oncotarget  2013;4:1948
  235. Epigenetic regulation of autophagy by the methyltransferase G9a.
    Authors: Narvajas Et al.
    Mol Cell Biol  2013;33:3983
  236. Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation.
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    Mol Cell Biol  2013;33:2285
  237. Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.
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    J Biol Chem  2013;288:35769
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  239. SYK regulates mTOR signaling in AML.
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    Leukemia  2013;27:2118
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  242. Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy.
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  243. Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes.
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  244. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.
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    Cell Metab  2013;18:698
  245. WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.
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  246. Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer.
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