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Tilfrinib

Catalog #: 5579 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5579/50
5579/10
Tilfrinib | CAS No. 1600515-49-8 | Src Family Kinase Inhibitors
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Description: Potent and selective breast tumor kinase (Brk) inhibitor

Chemical Name: 3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Tilfrinib is a potent and selective breast tumor kinase (Brk, also known as tyrosine-protein kinase 6, PTK6) inhibitor (IC50 = 3.15 nM). Exhibits >1000-fold selectivity for Brk over a panel of other kinases. Inhibits proliferation of breast cancer cells in vitro.

Technical Data

M.Wt:
275.3
Formula:
C17H13N3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1600515-49-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Martin-Luther-Universität-Halle-Wittenburg

Background References

  1. Discovery of 4-anilino α-carbolines as novel Brk inhibitors.
    Mahmoud et al.
    Bioorg.Med.Chem.Lett., 2014;24:1948

Product Datasheets

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