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THIP hydrochloride

Catalog #: 0807
13 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0807/50
THIP hydrochloride | CAS No. 85118-33-8 | GABA-A Receptor Agonists
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Description: GABAA agonist
Alternative Names: Gaboxadol

Chemical Name: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride

Purity: ≥98%

Product Details
Citations (13)
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Biological Activity

THIP hydrochloride is a systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

Technical Data

M.Wt:
176.6
Formula:
C6H8N2O2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
85118-33-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
    Seifi M, Brown J, Mills J, Bhandari P, Belelli D, Lambert J, Rudolph U, Swinny J
    , 2014;0(0):.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. GABAC receptors: relatively simple transmitter-gated ion channels?
    Johnston
    TiPS, 1996;17:319
  4. 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
    Krogsgaard-Larson
    J.Med.Chem., 1983;26:895
  5. Gaboxadol. Lundbeck/Merck
    Huckle
    Curr.Opin.Investig.Drugs, 2004;5:766
  6. Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine.
    Krogsgaard-Larson
    Drugs Future., 1984;9:597

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Citations for THIP hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for THIP hydrochloride include:

13 Citations: Showing 1 - 10

  1. Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive.
    Authors: Ki and Lim
    Elife  2019;8
  2. HIV gp120 upregulates tonic inhibition through α5-containing GABAARs.
    Authors: Green and Thayer Et al.
    Neuropharmacology  2019;149:161
  3. δ-subunit containing GABAA receptors modulate respiratory networks.
    Authors: Montandon
    Sci Rep  2017;7(1):18105
  4. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Neurophysiol  2016;36:607
  5. Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
    Authors: Tong Et al.
    J Neurosci  2015;35:16142
  6. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
    Authors: Seifi Et al.
    Nature  2014;34:10361
  7. Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome.
    Authors: Szemes Et al.
    Mol Brain  2013;6:33
  8. Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.
    Authors: Ramaker Et al.
    Neuropharmacology  2012;63:555
  9. Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
    Authors: Asiedu Et al.
    J Pain  2012;13:546
  10. Potentiating action of PropF. at GABAA receptors of retinal bipolar cells.
    Authors: Yue Et al.
    Invest Ophthalmol Vis Sci  2011;52:2497

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