Thalidomide, propargyl

Catalog # Availability Size / Price Qty
6685/50
Thalidomide, propargyl | CAS No. 2098487-39-7 | Degrader Building Blocks
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Description: Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione

Purity: ≥95%

Product Details
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Biological Activity

Thalidomide, propargyl is a click-activated Thalidomide (Cat.No. 0652); can be used as a precursor to a PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
312.28
Formula:
C16H12N2O5
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2098487-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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