Home / Glycosylase Inhibitors / TH 5487

TH 5487

Catalog #: 6749
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6749/50
6749/10
TH 5487 | CAS No. 2304947-71-3 | Glycosylase Inhibitors
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Description: Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

Chemical Name: 4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 342 nM). Selective for OGG1 over other base excision repair enzymes. Inhibits OGG1 binding to 8-oxoG in DNA and suppresses proinflammatory gene expression in TNF-α stimulated lung epithelial cells in vitro. Also inhibits proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs in vivo.

Technical Data

M.Wt:
541.18
Formula:
C19H18BrIN4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2304947-71-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Product Datasheets

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Citations for TH 5487

The citations listed below are publications that use Tocris products. Selected citations for TH 5487 include:

2 Citations: Showing 1 - 2

  1. Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSα facilitates processing of oxidative DNA damage in human cells.
    Authors: Janice Et al.
    J Biol Chem  2022;298:102102
  2. Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons.
    Authors: Eric L Et al.
    Int J Mol Sci  2022;23

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