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TH 5427 hydrochloride

Catalog #: 6534 Datasheet / COA / SDS
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6534/10
6534/50
TH 5427 hydrochloride | CAS No. 2253744-57-7 | Hydrolase Inhibitors
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Description: Potent NUDT5 inhibitor

Chemical Name: 7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride

Purity: ≥98%

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Biological Activity

TH 5427 hydrochloride is a potent nudix hydrolase 5 (NUDT5) inhibitor (IC50 = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.

Technical Data

M.Wt:
527.79
Formula:
C20H20Cl2N8O3.HCl
Solubility:
Soluble to 10 mM in water and to 20 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
2253744-57-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Background References

  1. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
    Page et al.
    Nat.Commun., 2018;9:250

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