Home / Hydrolase Inhibitors / TH 1760

TH 1760

Catalog #: 7422 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7422/10
7422/50
TH 1760 | CAS No. 2567914-01-4 | Hydrolase Inhibitors
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Description: Potent and selective NUDT15 hydrolase inhibitor

Chemical Name: 6-[[4-(1H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3H)-benzoxazolone

Purity: ≥95%

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Biological Activity

TH 1760 is a potent and selective NUDT15 (nudix hydrolase 15) inhibitor (IC50 = 29 nM). Displays selectivity for NUDT15 when assayed at 100 μM against other Nudix enzymes (MTH1, NUDT2, 5, 9, 12, 14, 18, 22) and pyrophosphatases or at 10 μM when assayed with a Eurofins Cerep Safety Screen44 panel. In vitro, TH 1760 treatment sensitizes cancer cell lines (NB4 and HL-60) to thiopurine.

Technical Data

M.Wt:
426.45
Formula:
C20H18N4O5S
Solubility:
Soluble to 4 mg/ml in DMSO with gentle warming
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2567914-01-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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