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TGF-beta 1, 2, 3 Antibody

Catalog #: MAB1835
225 Citations 12 Reviews Datasheet / COA / SDS
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MAB1835-SP
MAB1835-100
MAB1835-500
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TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta 1, 2, 3 Antibody.
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Citations (225)
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Reviews (12)
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TGF-beta 1, 2, 3 Antibody Summary

Specificity
Detects bovine, chicken, mouse, and human TGF-beta in ELISAs and Western blots. It recognizes human TGF-beta 1, TGF-beta 2, and TGF-beta 3. No cross-reactivity was observed with recombinant LAP in direct ELISAs.
Source
Monoclonal Mouse IgG1 Clone # 1D11
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Bovine bone-derived TGF-beta 1 and TGF-beta 2
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human TGF-beta 1 (Catalog # 240-B) under non-reducing conditions only

Human TGF-beta 1 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: TGF‑ beta 1 Biotinylated Antibody (Catalog # BAF240)

Standard: Recombinant Human TGF-beta 1 Protein (Catalog # 240-B)

Neutralization
Measured by its ability to neutralize TGF‑ beta 1 inhibition of IL‑4-dependent proliferation in the HT‑2 mouse T cell line. Tsang, M. et al. (1990) Lymphokine Res. 9:607. The Neutralization Dose (ND50) is typically 0.25-1.25 µg/mL in the presence of 1 ng/mL Recombinant Human TGF‑ beta 1 and 7.5 ng/mL Recombinant Mouse IL‑4.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Neutralization TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta 1, 2, 3 Antibody. View Larger

TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta 1, 2, 3 Antibody. Recombinant Human TGF-beta 1 (Catalog # 240-B) inhibits Recombinant Mouse IL-4 (Catalog # 404-ML) induced proliferation in the HT-2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Mouse IL-4 (7.5 ng/mL) activity elicited by Recombinant Human TGF-beta 1 (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-TGF-beta 1, 2, 3 Monoclonal Antibody (Catalog # MAB1835). The ND50 is typically 0.25-1.25 µg/mL.

In vivo assay Detection of Mouse TGF beta 1/2/3 by In vivo assay View Larger

Detection of Mouse TGF beta 1/2/3 by In vivo assay Apoptotic cell-induced immunomodulation in mice with collagen-induced arthritis (CIA) is dependent on transforming growth factor (TGF)-beta. CIA mice that received or did not receive apoptotic cells, with or without anti-TGF-beta blocking antibody were scored daily (a). Data are shown as mean ± SEM of five mice per group from one of two representative experiments; *p < 0.05, **p < 0.01 (Friedman test analysis of variance (ANOVA) with Dunn's multiple comparisons test). Anti-collagen IgG2a antibodies (Ab) were quantified in plasma (b). Data from 5 to 16 mice from two to three independent experiments (no difference, Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test). Lymph node cells were collected, cultured, and T cell proliferation in response to collagen protein or CD3-specific Ab stimulations was evaluated (c). Data are shown as mean ± SEM from one of two representative experiments; *p < 0.05, **p < 0.01 (nonparametric unpaired t test). Percent and absolute number of Foxp3+ T regulatory cells (Treg) were evaluated in the spleen (d) and suppressive assays were performed by isolating and adding Treg at a different ratio into collagen-specific cultures and responder T cell proliferation was assessed (e). Data are shown as mean ± SEM from one experiment (d Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test; e Friedman test ANOVA with Dunn’s multiple comparisons test). Plasmacytoid dendritic cells (pDC), conventional dendritic cells (cDC) and macrophages (macro) were isolated and cultured with naïve allogenic T cells to determine Treg polarization (f), and their response to TLR ligand was assessed through evaluation of CD40 costimulatory molecule expression (g). Data from individual mouse plus mean (black bar) from one experiment representative of four are shown; *p < 0.05, ***p < 0.001 (f ordinary one-way ANOVA with Tukey’s multiple comparisons test; g Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test). BrDU 5-Bromo-2’-deoxyuridine Image collected and cropped by CiteAb from the following publication (https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-016-1084-0), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human TGF beta 1/2/3 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human TGF beta 1/2/3 by Immunocytochemistry/Immunofluorescence TGF beta 1 stimulates the expression of ECM components in human and rabbit primary cells. (A) Selected ECM mRNA transcripts were measured using qRT-PCR in human RPTEC or human IPF134 following 48 hr stimulation with TGF beta 1 (10 ng/mL). Data show transcript abundance relative to the unstimulated control (indicated by the dashed line) and are shown as mean ± SD of four (RPTEC) or seven (IPF134) independent experiments. ****P < 0.0001; ****P < 0.001; **P < 0.01; Student’s t-test. (B) The accumulation of ECM in human RPTEC (i) or human IPF (ii) cells stimulated with 10ng/mL TGF beta 1 was evaluated via measurement of the incorporation of 14C-labelled amino acids into the deposited ECM. Data presented are the mean ± SD of three independent experiments. **P < 0.01; Student’s t-test. (C) Increased mature ECM accumulation following treatment of cells with a pro-fibrotic stimulus can be visualised following in-situ fluorescent staining using the Flamingo dye. Cells from three different systems (primary human RPTEC; primary human IPF134; co-culture of primary rabbit RPTEC with primary rabbit renal fibroblasts) were cultured in the absence (top) or presence (bottom) of 10 ng/ml TGF beta 1 before decellularised matrix was fixed and stained in situ with Flamingo fluorescent dye. Images show a single field. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28855577), licensed under a CC-BY license. Not internally tested by R&D Systems.

Flow Cytometry Detection of Mouse TGF-beta 1, 2, 3 Antibody by Flow Cytometry View Larger

Detection of Mouse TGF-beta 1, 2, 3 Antibody by Flow Cytometry CBirTox induced expression of Foxp3 is dependent on TGF-beta but independent of RA signaling.(A) CD11c+ DCs were isolated from the spleen, MLN or LP and pulsed with 1 μg/ml of CBirTox or CBir1 peptide for 2 hours prior to co-culture with CD4+ CBir1 Tg T cells for 4 days before flow cytometry analysis. Results represent 2–3 independent experiments (B-C) CD11c+ DCs were isolated from the spleen and pulsed with 1 μg/ml of CBirTox for 1 hour before co-culture with CD4+ CBir1 Tg T cells in the presence of 1 μM of the RA inhibitor LE135 or RA for 4 days. Representative flow plots (B) of 3 independent experiments (C) are shown. (D-E) Splenic CD19+ B cells were pulsed with 2 μg of CBirTox for 2 hours before co-culture with with CD4+ CBir1 Tg T cells with or without the presence of 10 μg/ml anti-TGF-beta (1,2,3) for 4 days prior to flow cytometry analysis. Representative flow plots (D) of 4–5 independent experiments (E) are shown. Results of all experiments are expressed as the mean ± SEM. ***p<0.0005, NS, not significant. Groups of three or more were analyzed using one-way ANOVA with Bonferroni’s post test. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28750075), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TGF-beta 1, 2, 3

TGF-beta 1, -2, and -3 are a closely related group of proteins (70‑80% sequence homology) that are produced by many cell types and function as growth and differentiation factors. The active forms of TGF-beta 1, -2, and -3 are disulfide-linked homodimers.

References
  1. Ayala A. et al. (1992) FASEB J. 6:A1604.
  2. Roberts A.B. and Sporn M.B., eds. (1990) Peptide Growth Factors and Their Receptors I, Springer-Verlag, 419.
  3. Dasch J.R. et al. (1989) J. Immunol. 142:1536.
Long Name
Transforming Growth Factor beta 1, 2, and 3
Alternate Names
CED; DPD1; LAP; TGFB; TGFB1; TGF-beta 1, 2, 3; TGFbeta; transforming growth factor, beta 1

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Citations for TGF-beta 1, 2, 3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

225 Citations: Showing 1 - 10
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  1. Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in stage 4/M neuroblastoma
    Authors: P Linares-Cl, D Aguilar-Mo, I Rodríguez-, G Ramírez, C de Torres, V Santamaría, D Pascual-Va, A Colmenero-, FM Vega, J Mora, R Cabello, C Márquez, E Rivas, R Pardal
    Oncotarget, 2017-09-21;8(52):89775-89792.
  2. Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ
    Authors: G Holdsworth, H Bon, M Bergin, O Qureshi, R Paveley, J Atkinson, L Huang, R Tewari, B Twomey, T Johnson
    Sci Rep, 2017-08-30;7(1):9963.
  3. FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway.
    Authors: Li J, Shi S, et al.
    Cell Death Dis
  4. Prostaglandin E2 and Transforming Growth Factor-beta Play a Critical Role in Suppression of Allergic Airway Inflammation by Adipose-Derived Stem Cells.
    Authors: Cho K, Lee J, Park M, Park H, Yu H, Roh H
    PLoS ONE, 2015-07-15;10(7):e0131813.
  5. Suppression of latent transforming growth factor (TGF)-beta1 restores growth inhibitory TGF-beta signaling through microRNAs.
    Authors: Dogar AM, Towbin H, Hall J
    J. Biol. Chem., 2011-03-14;286(18):16447-58.
  6. Bovine Milk‐Derived Extracellular Vesicles Inhibit Catabolic and Inflammatory Processes in Cartilage from Osteoarthritis Patients
    Authors: Bartijn C. H. Pieters, Onno J. Arntz, Joyce Aarts, Anouk L. Feitsma, R. J. Joost van Neerven, Peter M. van der Kraan et al.
    Molecular Nutrition & Food Research
  7. Epithelial-mesenchymal transition induced by tumor cell-intrinsic PD-L1 signaling predicts a poor response to immune checkpoint inhibitors in PD-L1-high lung cancer
    Authors: Jeong, H;Koh, J;Kim, S;Song, SG;Lee, SH;Jeon, Y;Lee, CH;Keam, B;Lee, SH;Chung, DH;Jeon, YK;
    British journal of cancer
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  8. Soluble NKG2DLs Are Elevated in Breast Cancer Patients and Associate with Disease Outcome
    Authors: Seller, A;Tegeler, CM;Mauermann, J;Schreiber, T;Hagelstein, I;Liebel, K;Koch, A;Heitmann, JS;Greiner, SM;Hayn, C;Dannehl, D;Engler, T;Hartkopf, AD;Hahn, M;Brucker, SY;Salih, HR;Märklin, M;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model
    Authors: Kostadinova, R;Ströbel, S;Chen, L;Fiaschetti-Egli, K;Gadient, J;Pawlowska, A;Petitjean, L;Bieri, M;Thoma, E;Petitjean, M;
    Scientific reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. NEDD8-activating enzyme inhibition potentiates the anti-myeloma activity of natural killer cells
    Authors: Petillo, S;Sproviero, E;Loconte, L;Cuollo, L;Zingoni, A;Molfetta, R;Fionda, C;Soriani, A;Cerboni, C;Petrucci, MT;Fazio, F;Paolini, R;Santoni, A;Cippitelli, M;
    Cell death & disease
    Applications: Neutralization
  11. Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones
    Authors: Carneiro, CS;Hapeman, JD;Nedelcu, AM;
    BMC ecology and evolution
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion
    Authors: Michielon, E;López González, M;Stolk, DA;Stolwijk, JGC;Roffel, S;Waaijman, T;Lougheed, SM;de Gruijl, TD;Gibbs, S;
    Cancers
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  13. TGF-? Type I Receptor Signaling in Melanoma Liver Metastases Increases Metastatic Outgrowth
    Authors: Marvin, DL;Dijkstra, J;Zulfiqar, RM;Vermeulen, M;Ten Dijke, P;Ritsma, L;
    International journal of molecular sciences
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  14. The human placenta shapes the phenotype of decidual macrophages
    Authors: S Vondra, AL Höbler, AI Lackner, J Raffetsede, ZN Mihalic, A Vogel, L Saleh, V Kunihs, P Haslinger, M Wahrmann, H Husslein, R Oberle, J Kargl, S Haider, P Latos, G Schabbauer, M Knöfler, J Ernerudh, J Pollheimer
    Cell Reports, 2023-01-10;42(1):111977.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  15. Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs
    Authors: SI Gringhuis, TM Kaptein, EBM Remmerswaa, A Drewniak, BA Wevers, B Theelen, GRAM D'Haens, T Boekhout, TBH Geijtenbee
    Nature Immunology, 2022-12-01;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Capture
  16. CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype
    Authors: W Zeng, L Xiong, W Wu, S Li, J Liu, L Yang, L Lao, P Huang, M Zhang, H Chen, N Miao, Z Lin, Z Liu, X Yang, J Wang, P Wang, E Song, Y Yao, Y Nie, J Chen, D Huang
    Oncogene, 2022-11-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  17. Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration
    Authors: A Nawaz, M Bilal, S Fujisaka, T Kado, MR Aslam, S Ahmed, K Okabe, Y Igarashi, Y Watanabe, T Kuwano, K Tsuneyama, A Nishimura, Y Nishida, S Yamamoto, M Sasahara, J Imura, H Mori, MM Matzuk, F Kudo, I Manabe, A Uezumi, T Nakagawa, Y Oishi, K Tobe
    Nature Communications, 2022-11-21;13(1):7058.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  18. Influence of tumor cell-derived TGF-beta on macrophage phenotype and macrophage-mediated tumor cell invasion
    Authors: LAG Maldonado, CR Nascimento, NAR Fernandes, ALP Silva, NJ D'Silva, C Rossa
    The international journal of biochemistry & cell biology, 2022-11-04;153(0):106330.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  19. Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease
    Authors: Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang
    EBioMedicine, 2022-09-28;85(0):104285.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  20. Anti-TGF-beta 1 aptamer enhances therapeutic effect of tyrosine kinase inhibitor, gefitinib, on non-small cell lung cancer in xenograft model
    Authors: Masaki Takahashi, Yoshifumi Hashimoto, Yoshikazu Nakamura
    Molecular Therapy - Nucleic Acids
  21. Twist-related protein 1 induces epithelial-mesenchymal transition and renal fibrosis through the upregulation of complement 3
    Authors: T Otsuki, N Fukuda, L Chen, A Tsunemi, M Abe
    PLoS ONE, 2022-08-26;17(8):e0272917.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  22. Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity
    Authors: J Hanna, F Beke, LM O'Brien, C Kapeni, HC Chen, V Carbonaro, AB Kim, K Kishore, TE Adolph, MO Skjoedt, K Skjoedt, M de la Roch, M de la Roch
    Nature Communications, 2022-07-14;13(1):4075.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  23. Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function
    Authors: GN Yin, DK Kim, JI Kang, Y Im, DS Lee, AR Han, J Ock, MJ Choi, MH Kwon, A Limanjaya, SB Jung, J Yang, KW Min, J Yun, Y Koh, JE Park, D Hwang, JK Suh, JK Ryu, HM Kim
    Experimental & Molecular Medicine, 2022-05-13;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  24. Age-associated callus senescent cells produce TGF-beta 1 that inhibits fracture healing in aged mice
    Authors: Jiatong Liu, Jun Zhang, Xi Lin, Brendan F. Boyce, Hengwei Zhang, Lianping Xing
    Journal of Clinical Investigation
  25. Platelets subvert antitumor efficacy of T cell-recruiting bispecific antibodies
    Authors: Martina Svenja Lutz, Boris Klimovich, Stefanie Maurer, Jonas S Heitmann, Melanie Märklin, Latifa Zekri et al.
    Journal for ImmunoTherapy of Cancer
  26. Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-beta Production
    Authors: Jia He, Yue Du, Gaopeng Li, Peng Xiao, Xingzheng Sun, Wenjun Song et al.
    Frontiers in Immunology
  27. Visceral fat‐specific regulation of plasminogen activator inhibitor‐1 in aged septic mice
    Authors: Maria E. C. Bruno, Sujata Mukherjee, Arnold J. Stromberg, Hiroshi Saito, Marlene E. Starr
    Journal of Cellular Physiology
  28. Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis
    Authors: D Basak, Z Jamal, A Ghosh, PK Mondal, P Dey Talukd, S Ghosh, B Ghosh Roy, R Ghosh, A Halder, A Chowdhury, GK Dhali, BK Chattopadh, ML Saha, A Basu, S Roy, C Mukherjee, NK Biswas, U Chatterji, S Datta
    PLoS ONE, 2021-08-11;16(8):e0255915.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Co-IP, Western Blot
  29. Methods to improve efficacy of orally administered bioactive peptides using bovine colostrum as an exemplar
    Authors: RJ Playford, MJ Weiser, T Marchbank
    PLoS ONE, 2021-06-17;16(6):e0253422.
    Species: Bovine
    Sample Types: Milk
    Applications: ELISA Capture
  30. Human Keratinocytes Inhibit CD4+ T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints
    Authors: G Mestrallet, F Auvré, C Schenowitz, ED Carosella, J LeMaoult, MT Martin, N Rouas-Frei, NO Fortunel
    Cells, 2021-06-08;10(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  31. Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis
    Authors: Laura Duffy, John Henderson, Max Brown, Stefan Pryzborski, Nicola Fullard, Lena Summa et al.
    Frontiers in Cell and Developmental Biology
  32. Tumor‐associated macrophages promote the metastasis and growth of non‐small‐cell lung cancer cells through NF‐ kappa B/PP2Ac‐positive feedback loop
    Authors: Zhan‐Wen Liang, Xin‐Xin Ge, Meng‐Dan Xu, Hualong Qin, Meng‐Yao Wu, Meng Shen et al.
    Cancer Science
  33. 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration
    Authors: KV Manian, CA Galloway, S Dalvi, AA Emanuel, JA Mereness, W Black, L Winschel, C Soto, Y Li, Y Song, W DeMaria, A Kumar, I Slukvin, MP Schwartz, WL Murphy, B Anand-Apte, M Chung, DSW Benoit, R Singh
    Cell Stem Cell, 2021-03-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  34. Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-&beta signaling
    Authors: MR Patel, AM Weaver
    Cell Reports, 2021-03-09;34(10):108829.
    Species: Rat
    Sample Types: Cell Lysates, Whole Cells
    Applications: Dot Blot, Western Blot
  35. Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-&beta1 signaling pathway
    Authors: QS Liang, JG Xie, C Yu, Z Feng, J Ma, Y Zhang, D Wang, J Lu, R Zhuang, J Yin
    Experimental & Molecular Medicine, 2021-03-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  36. Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy.
    Authors: Sonia Iyer, Shuang Zhang, Simge Yucel, Heiko Horn, Sean G. Smith, Ferenc Reinhardt et al.
    Cancer Discovery
  37. RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGF&beta1 in the Suppression of Cell Motility
    Authors: H Ungefroren, H Otterbein, UF Wellner, T Keck, H Lehnert, JU Marquardt
    Cancers, 2020-11-29;12(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  38. Full-length IL-33 regulates Smad3 phosphorylation and gene transcription in a distinctive AP2-dependent manner
    Authors: Irina G. Luzina, Rita Fishelevich, Brian S. Hampton, Jean-Paul Courneya, Francesca R. Parisella, Katerina N. Lugkey et al.
    Cellular Immunology
  39. Influence of antigen density and immunosuppressive factors on tumor-targeted costimulation with antibody-fusion proteins and bispecific antibody-mediated T cell response
    Authors: Sabrina Sapski, Nadine Beha, Roland E. Kontermann, Dafne Müller
    Cancer Immunology, Immunotherapy
  40. A Role for HAPLN1 During Phenotypic Modulation of Human Lung Fibroblasts In Vitro
    Authors: Stephen P. Evanko, Michel D. Gooden, Inkyung Kang, Christina K. Chan, Robert B. Vernon, Thomas N. Wight
    Journal of Histochemistry & Cytochemistry
  41. Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo
    Authors: Mahmoud Elashiry, Mohamed M. Elashiry, Ranya Elsayed, Mythily Rajendran, Carol Auersvald, Rana Zeitoun et al.
    Journal of Extracellular Vesicles
  42. Age-induced accumulation of methylmalonic acid promotes tumour progression
    Authors: AP Gomes, D Ilter, V Low, JE Endress, J Fernández-, A Rosenzweig, T Schild, D Broekaert, A Ahmed, M Planque, I Elia, J Han, C Kinzig, E Mullarky, AP Mutvei, J Asara, R de Cabo, LC Cantley, N Dephoure, SM Fendt, J Blenis
    Nature, 2020-08-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  43. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
    Authors: LF Campesato, S Budhu, J Tchaicha, CH Weng, M Gigoux, IJ Cohen, D Redmond, L Mangarin, S Pourpe, C Liu, R Zappasodi, D Zamarin, J Cavanaugh, AC Castro, MG Manfredi, K McGovern, T Merghoub, JD Wolchok
    Nat Commun, 2020-08-11;11(1):4011.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  44. Tgf beta signaling is required for tenocyte recruitment and functional neonatal tendon regeneration
    Authors: Deepak A Kaji, Kristen L Howell, Zerina Balic, Dirk Hubmacher, Alice H Huang
    eLife
  45. T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice
    Authors: W Li, AS Elshikha, C Cornaby, X Teng, G Abboud, J Brown, X Zou, L Zeumer-Spa, B Robusto, SC Choi, K Fredenburg, A Major, L Morel
    JCI Insight, 2020-06-04;5(11):.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Variations in Circulating Active MMP-9 Levels During Renal Replacement Therapy
    Authors: E Rodríguez-, JA Navarro-Ga, J Aceves-Rip, J Abarca-Zab, A Susmozas-S, T Bada-Bosch, E Hernández, E Mérida-Her, A Andrés, M Praga, M Fernández-, JM Aguado, J Segura, LM Ruilope, G Ruiz-Hurta
    Biomolecules, 2020-03-26;10(4):.
    Species: Human
    Sample Types: Plasma
  47. TGF&beta-mediated expression of TGF&beta-activating integrins in SSc monocytes: disturbed activation of latent TGF&beta?
    Authors: A van Caam, J Aarts, T van Ee, E Vitters, M Koenders, F van de Loo, P van Lent, F van den Ho, R Thurlings, MC Vonk, PM van der Kr
    Arthritis Res. Ther., 2020-03-06;22(1):42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  48. Anti-TGF-&beta attenuates tumor growth via polarization of tumor associated neutrophils towards an anti-tumor phenotype in colorectal cancer
    Authors: F Qin, X Liu, J Chen, S Huang, W Wei, Y Zou, X Liu, K Deng, S Mo, J Chen, X Chen, Y Huang, W Liang
    J Cancer, 2020-02-14;11(9):2580-2592.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  49. Reversible EMT and MET mediate amnion remodeling during pregnancy and labor
    Authors: Richardson LS, Taylor RN, Menon R.
    Science Signaling
  50. Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance through the CXCL12/CXCR4/mTOR/TGF&beta Signaling Pathway in Breast Cancer Cells
    Authors: S Li, Y Fan, A Kumagai, E Kawakita, M Kitada, K Kanasaki, D Koya
    Int J Mol Sci, 2020-01-26;21(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  51. Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis
    Authors: Y Takagaki, SM Lee, Z Dongqing, M Kitada, K Kanasaki, D Koya
    Autophagy, 2020-01-22;0(0):1-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  52. Human Cytomegalovirus miRNAs Regulate TGF-beta to Mediate Myelosuppression while Maintaining Viral Latency in CD34+ Hematopoietic Progenitor Cells
    Authors: Meaghan H. Hancock, Lindsey B. Crawford, Andrew H. Pham, Jennifer Mitchell, Hillary M. Struthers, Andrew D. Yurochko et al.
    Cell Host & Microbe
  53. BMPR2 acts as a�gatekeeper to protect endothelial cells from increased TGF&beta�responses and altered cell mechanics
    Authors: C Hiepen, J Jatzlau, S Hildebrand, B Kampfrath, M Goktas, A Murgai, JL Cuellar Ca, R Haag, C Ruppert, G Sengle, EA Cavalcanti, KG Blank, P Knaus
    PLoS Biol., 2019-12-11;17(12):e3000557.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  54. Anatomically specific reactive oxygen species production participates in Marfan syndrome aneurysm formation
    Authors: Fabian Emrich, Kiril Penov, Mamoru Arakawa, Nathan Dhablania, Grayson Burdon, Albert J. Pedroza et al.
    Journal of Cellular and Molecular Medicine
  55. Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells
    Authors: MR Shokri, M Bozorgmehr, A Ghanavatin, R Falak, M Aleahmad, S Kazemnejad, F Shokri, AH Zarnani
    Sci Rep, 2019-07-10;9(1):10007.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate
    Authors: Wenshan Wang, Jeff Ishibashi, Sophie Trefely, Mengle Shao, Alexis J. Cowan, Alexander Sakers et al.
    Cell Metabolism
  57. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
    Authors: Matteo Ligorio, Srinjoy Sil, Jose Malagon-Lopez, Linda T. Nieman, Sandra Misale, Mauro Di Pilato et al.
    Cell
  58. TGF??1 upregulates the expression of lncRNA?ATB to promote atherosclerosis
    Authors: H Yu, S Ma, L Sun, J Gao, C Zhao
    Mol Med Rep, 2019-03-29;19(5):4222-4228.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Development (Capture)
  59. BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced rat DIC model
    Authors: B Wang, S Wu, Z Ma, T Wang, C Yang
    Cell Death Dis, 2018-10-03;9(10):1024.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  60. TGF-?1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA
    Authors: T Shindo, S Doi, A Nakashima, K Sasaki, K Arihiro, T Masaki
    Sci Rep, 2018-09-19;8(1):14060.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  61. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells
    Authors: M Idelson, R Alper, A Obolensky, N Yachimovic, J Rachmilewi, A Ejzenberg, E Beider, E Banin, B Reubinoff
    Stem Cell Reports, 2018-08-16;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  62. Separation of cell survival, growth, migration, and mesenchymal transdifferentiation effects of fibroblast secretome on tumor cells of head and neck squamous cell carcinoma
    Authors: Veronika Maria Metzler, Christian Pritz, Anna Riml, Angela Romani, Raphaela Tuertscher, Teresa Steinbichler et al.
    Tumour Biol.
  63. TGF-?1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells
    Authors: X Wang, F Dong, S Zhang, W Yang, W Yu, Z Wang, S Zhang, J Wang, S Ma, P Wu, Y Gao, J Dong, F Tang, T Cheng, H Ema
    Stem Cell Reports, 2018-06-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  64. Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF??.
    Authors: Bing Liu, Lili Xu, Xinming Yu, Wei Li, Xiaozhi Sun, Shun Xiao, Mingjin Guo, Haofu Wang
    Molecular Medicine Reports, 2018-06-20;0(0):1791-3004.
    Species: Human
    Sample Types: Cell Lysate, Cell Lysates
    Applications: Western Blot
  65. Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a
    Authors: S Tiwary, JE Morales, SC Kwiatkowsk, FF Lang, G Rao, JH McCarty
    Sci Rep, 2018-05-29;8(1):8267.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  66. CD8+ T cells with high TGF??1 expression cause lymph node fibrosis following HIV infection
    Authors: L Huang, J Deng, W Xu, H Wang, L Shi, F Wu, D Wu, W Nei, M Zhao, P Mao, X Zhou
    Mol Med Rep, 2018-05-03;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Agonist Activity
  67. Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression
    Authors: SS Said, GT Barut, N Mansur, A Korkmaz, A Sayi-Yazga
    Mol. Immunol., 2018-02-26;96(0):48-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  68. RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis
    Authors: JR Cortes, A Ambesi-Imp, L Couronné, SA Quinn, CS Kim, AC da Silva A, Z West, L Belver, MS Martin, L Scourzic, G Bhagat, OA Bernard, AA Ferrando, T Palomero
    Cancer Cell, 2018-02-02;33(2):259-273.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Activation
  69. Proteomic Analysis of Nucleus Pulposus Cell-derived Extracellular Matrix Niche and Its Effect on Phenotypic Alteration of Dermal Fibroblasts
    Authors: M Yuan, PJ Pai, X Liu, H Lam, BP Chan
    Sci Rep, 2018-01-24;8(1):1512.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: ICC
  70. Downregulation of membrane trafficking proteins and lactate conditioning determine loss of dendritic cell function in lung cancer
    Authors: N Caronni, F Simoncello, F Stafetta, C Guarnaccia, JS Ruiz-Moren, B Opitz, T Galli, V Proux-Gill, F Benvenuti
    Cancer Res., 2018-01-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-? signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis
    Authors: CKS Wong, A Falkenham, T Myers, JF Légaré
    J Renin Angiotensin Aldosterone Syst, 2018-01-01;19(1):1470320318759.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  72. Evidence of lateral transmission of aggressive features between different types of breast cancer cells
    Authors: Nancy Adriana Espinoza-Sánchez, Eduardo Vadillo, Juan Carlos Balandrán, Alberto Monroy-García, Rosana Pelayo, Ezequiel M. Fuentes-Pananá
    International Journal of Oncology
  73. Greater transforming growth factor-beta in adult female SHR is dependent on blood pressure, but does not account for sex differences in renal T-regulatory cells
    Authors: Ashlee J. Tipton, Jacqueline B. Musall, G. Ryan Crislip, Jennifer C. Sullivan
    American Journal of Physiology-Renal Physiology
  74. Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3(+) regulatory T cells
    Authors: M Pasztoi, J Pezoldt, M Beckstette, C Lipps, D Wirth, M Rohde, K Paloczi, EI Buzas, J Huehn
    Eur. J. Immunol., 2017-09-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  75. CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors
    Authors: Allah Nawaz, Aminuddin Aminuddin, Tomonobu Kado, Akiko Takikawa, Seiji Yamamoto, Koichi Tsuneyama et al.
    Nature Communications
  76. Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function
    Authors: RM Petri, A Hackel, K Hahnel, CA Dumitru, K Bruderek, SB Flohe, A Paschen, S Lang, S Brandau
    Stem Cell Reports, 2017-08-03;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  77. Granulocytic myeloid derived suppressor cells from human cord blood modulate T-helper-cell response towards an anti-inflammatory phenotype
    Authors: N Köstlin, M Vogelmann, B Spring, J Schwarz, J Feucht, C Härtel, TW Orlikowsky, CF Poets, C Gille
    Immunology, 2017-06-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  78. TGF-? signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes
    Authors: S Khakipoor, C Ophoven, M Schrödl-Hä, M Feuerstein, B Heimrich, JW Deitmer, E Roussa
    Glia, 2017-06-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Neutralization
  79. Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
    Authors: CJ Bohlen, FC Bennett, AF Tucker, HY Collins, SB Mulinyawe, BA Barres
    Neuron, 2017-05-17;94(4):759-773.e8.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  80. ALS skeletal muscle shows enhanced TGF-? signaling, fibrosis and induction of fibro/adipogenic progenitor markers
    Authors: D Gonzalez, O Contreras, DL Rebolledo, JP Espinoza, B van Zunder, E Brandan
    PLoS ONE, 2017-05-16;12(5):e0177649.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  81. Platelets subvert T cell immunity against cancer via GARP-TGF beta axis
    Authors: Saleh Rachidi, Alessandra Metelli, Brian Riesenberg, Bill X. Wu, Michelle H. Nelson, Caroline W Wallace et al.
    Science Immunology
  82. Integrin ?1 activation induces an anti-melanoma host response
    Authors: L Ritsma, I Dey-Guha, N Talele, X Sole, Salony, J Chowdhury, KN Ross, S Ramaswamy
    PLoS ONE, 2017-04-27;12(4):e0175300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Functional Assay
  83. The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study
    Authors: K Brekke, M Sommerfelt, M Ökvist, AM Dyrhol-Rii, D Kvale
    BMC Infect. Dis, 2017-03-24;17(1):228.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  84. Mechanosignaling activation of TGF? maintains intervertebral disc homeostasis
    Authors: Q Bian, L Ma, A Jain, JL Crane, K Kebaish, M Wan, Z Zhang, X Edward Guo, PD Sponseller, CA Séguin, LH Riley, Y Wang, X Cao
    Bone Res, 2017-03-21;5(0):17008.
    Species: Mouse, Rat
    Sample Types: In Vivo, Whole Tissue
    Applications: Bioassay, Neutralization
  85. A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw
    Authors: DJ Urban, N Anthwal, ZX Luo, JA Maier, A Sadier, AS Tucker, KE Sears
    Proc. Biol. Sci, 2017-02-08;284(1848):.
    Species: Opossum
    Sample Types: In Vivo
    Applications: In Vivo
  86. Histone Deacetylase (HDAC) Inhibition Induces I?B Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells
    Authors: HR Gatla, Y Zou, MM Uddin, B Singha, P Bu, A Vancura, I Vancurova
    J. Biol. Chem., 2017-02-06;292(12):5043-5054.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  87. Examining Crosstalk among Transforming Growth Factor beta, Bone Morphogenetic Protein, and Wnt Pathways*
    Authors: Adam D. Coster, Curtis A. Thorne, Lani F. Wu, Steven J. Altschuler
    Journal of Biological Chemistry
  88. Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis
    Authors: Massimiliano Mellone, Christopher J. Hanley, Steve Thirdborough, Toby Mellows, Edwin Garcia, Jeongmin Woo et al.
    Aging (Albany NY)
  89. Kluyveromyces marxianus and Saccharomyces boulardii Induce Distinct Levels of Dendritic Cell Cytokine Secretion and Significantly Different T Cell Responses In Vitro
    PLoS ONE, 2016-11-29;11(11):e0167410.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  90. Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury
    Authors: Jeremy S Duffield
    J. Clin. Invest., 2016-11-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  91. Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion
    PLoS ONE, 2016-11-16;11(11):e0166500.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  92. Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs
    Nature, 2016-11-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Cancer associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-�-dependent pathways in genotype-specific oral cancer
    Authors: S S Prime
    Carcinogenesis, 2016-11-01;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Neutralization
  94. Sterile Inflammation Enhances ECM Degradation in Integrin ?1 KO Embryonic Skin
    Cell Rep, 2016-09-20;16(12):3334-47.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  95. TGF-?1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT)
    PLoS ONE, 2016-09-02;11(9):e0162221.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  96. [64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma
    Authors: I Minn, SM Koo, HS Lee, M Brummet, SP Rowe, MA Gorin, P Sysa-Shah, WD Lewis, HH Ahn, Y Wang, SR Banerjee, RC Mease, S Nimmagadda, ME Allaf, MG Pomper, X Yang
    Oncotarget, 2016-08-30;7(35):56471-56479.
    Species: Mink
    Sample Types: Whole Cells
    Applications: Neutralization
  97. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes
    Stem Cell Reports, 2016-08-25;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  98. Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy
    Arthritis Res Ther, 2016-08-11;18(1):184.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  99. K+/Cl- cotransporter KCC2 membrane trafficking and functionality is regulated by transforming growth factor beta 2
    J Cell Sci, 2016-08-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-? signalling
    Authors: Fatemeh Mirzamoham
    Nat Commun, 2016-06-22;7(0):12047.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  101. Loss of GFAT1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer
    Authors: Fangfang Duan, Dongwei Jia, Junjie Zhao, Weicheng Wu, Lingqiang Min, Shushu Song et al.
    Oncotarget
  102. Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta.
    Authors: Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J
    Immunol Cell Biol, 2016-05-10;94(8):747-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  103. TGF-? Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions
    Authors: X Chen, DL Rateri, DA Howatt, A Balakrishn, JJ Moorleghen, LA Cassis, A Daugherty
    PLoS ONE, 2016-04-22;11(4):e0153811.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  104. TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development
    Authors: H Nagashima, Y Okuyama, T Hayashi, N Ishii, T So
    J Immunol, 2016-04-13;0(0):.
  105. Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-beta 1
    Authors: Holly E. M. Mewhort, Brodie D. Lipon, Daniyil A. Svystonyuk, Guoqi Teng, David G. Guzzardi, Claudia Silva et al.
    American Journal of Physiology-Heart and Circulatory Physiology
  106. Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy
    Authors: Hang Yuan, Marpadga A. Reddy, Supriya Deshpande, Ye Jia, Jung Tak Park, Linda L. Lanting et al.
    Antioxidants & Redox Signaling
  107. Development and characterization of human monoclonal antibodies that neutralize multiple TGF beta isoforms
    Authors: Daniel Bedinger, Llewelyn Lao, Shireen Khan, Steve Lee, Toshihiko Takeuchi, Amer M. Mirza
    mAbs
  108. CD4+CD25+ Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis B Virus Transgenic Mice via Membrane-Bound TGF-beta and OX40
    Authors: Yongyan Chen, Rui Sun, Xunyao Wu, Min Cheng, Haiming Wei, Zhigang Tian
    Journal of Innate Immunity
  109. Autoimmune regulator-overexpressing dendritic cells induce T helper 1 and T helper 17 cells by upregulating cytokine expression
    Authors: HAIJUN LI, DONGBEI LI, JITONG SUN, YINAN LI, WEI YANG, YI LI
    Molecular Medicine Reports
  110. Muscleblind-like 1 is required for normal heart valve development in vivo
    Authors: Ryan J. Coram, Samantha J. Stillwagon, Anuradha Guggilam, Michael W. Jenkins, Maurice S. Swanson, Andrea N. Ladd
    BMC Developmental Biology
  111. Treatment of dextran sodium sulfate-induced experimental colitis by adoptive transfer of peritoneal cells
    Authors: Ting Liu, Jun Ren, Wei Wang, Xia-wei Wei, Guo-bo Shen, Yan-tong Liu et al.
    Scientific Reports
  112. Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-beta Signaling.
    Authors: Carthy J, Engstrom U, Heldin C, Moustakas A
    J Cell Biochem, 2015-09-22;117(4):938-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. STAT6-Dependent Collagen Synthesis in Human Fibroblasts Is Induced by Bovine Milk.
    Authors: Kippenberger S, Zoller N, Kleemann J, Muller J, Kaufmann R, Hofmann M, Bernd A, Meissner M, Valesky E
    PLoS ONE, 2015-07-02;10(7):e0131783.
    Species: Bovine
    Sample Types: Milk
    Applications: Neutralization
  114. Mammary epithelial cell phagocytosis downstream of TGF-beta3 is characterized by adherens junction reorganization.
    Authors: Fornetti J, Flanders K, Henson P, Tan A, Borges V, Schedin P
    Cell Death Differ, 2015-06-26;23(2):185-96.
    Species: Rat
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  115. Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution
    Authors: Rugmani Padmanabhan Iyer, Nicolle L. Patterson, Fouad A. Zouein, Yonggang Ma, Vincent Dive, Lisandra E. de Castro Brás et al.
    International Journal of Cardiology
  116. Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-beta.
    Authors: Pieters B, Arntz O, Bennink M, Broeren M, van Caam A, Koenders M, van Lent P, van den Berg W, de Vries M, van der Kraan P, van de Loo F
    PLoS ONE, 2015-03-30;10(3):e0121123.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  117. Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-beta (TGF-beta) Activation and Fibroblast Differentiation.
    Authors: Dayer C, Stamenkovic I
    J Biol Chem, 2015-03-30;290(22):13763-78.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  118. Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-beta Signaling in the Retinal Pigment Epithelium.
    Authors: Li Y, Song D, Song Y, Zhao L, Wolkow N, Tobias J, Song W, Dunaief J
    J Biol Chem, 2015-03-23;290(19):11918-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  119. IL-10 inhibits neuraminidase-activated TGF-beta and facilitates Th1 phenotype during early phase of infection.
    Authors: Dutta A, Huang C, Chen T, Lin C, Chiu C, Lin Y, Chang C, He Y
    Nat Commun, 2015-03-02;6(0):6374.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  120. Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-beta.
    Authors: Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El-Sayed K, Ehnert S, Nussler A, Fandrich F, Gieseler F
    PLoS ONE, 2015-02-23;10(2):e0118097.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  121. Bortezomib inhibits expression of TGF-beta1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells.
    Authors: Chang T, Poltoratsky V, Vancurova I
    J Immunol, 2015-02-13;194(6):2942-53.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  122. Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity.
    Authors: Carrillo-Galvez A, Cobo M, Cuevas-Ocana S, Gutierrez-Guerrero A, Sanchez-Gilabert A, Bongarzone P, Garcia-Perez A, Munoz P, Benabdellah K, Toscano M, Martin F, Anderson P
    Stem Cells, 2015-01-01;33(1):183-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  123. Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
    Authors: Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong J, Tan Y, Thumboo J, van Loosdregt J, Albani S
    J Immunol, 2014-12-01;194(1):113-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  124. Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition.
    Authors: Mizuuchi Y, Aishima S, Ohuchida K, Shindo K, Fujino M, Hattori M, Miyazaki T, Mizumoto K, Tanaka M, Oda Y
    Lab Invest, 2014-11-24;95(2):193-206.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  125. STAT3 governs hyporesponsiveness and granzyme B-dependent suppressive capacity in human CD4+ T cells.
    Authors: Schmetterer K, Neunkirchner A, Wojta-Stremayr D, Leitner J, Steinberger P, Pickl W
    FASEB J, 2014-11-14;29(3):759-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Blocking
  126. Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation.
    Authors: Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G
    J Biol Chem, 2014-10-22;289(51):35246-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  127. Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion.
    Authors: Hassona Y, Cirillo N, Heesom K, Parkinson E, Prime S
    Br J Cancer, 2014-08-12;111(6):1230-7.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Neutralization
  128. Bovine gammadelta T cells are a major regulatory T cell subset.
    Authors: Guzman E, Hope J, Taylor G, Smith A, Cubillos-Zapata C, Charleston B
    J Immunol, 2014-06-02;193(1):208-22.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-beta.
    Authors: Alcaraz L, Exposito J, Chuvin N, Pommier R, Cluzel C, Martel S, Sentis S, Bartholin L, Lethias C, Valcourt U
    J Cell Biol, 2014-05-12;205(3):409-28.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Neutralization, Western Blot
  130. Functional effects of TGF-beta1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma.
    Authors: Gao P, Zhou Y, Xian L, Li C, Xu T, Plunkett B, Huang S, Wan M, Cao X
    J Immunol, 2014-04-07;192(10):4560-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  131. The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
    Authors: Nagashima, Hiroyuki, Okuyama, Yuko, Asao, Atsuko, Kawabe, Takeshi, Yamaki, Satoshi, Nakano, Hiroyasu, Croft, Michael, Ishii, Naoto, So, Takanori
    Nat Immunol, 2014-03-30;15(5):449-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  132. CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice.
    Authors: Lin Z, Wang C, Xia H, Liu W, Xiao W, Qian L, Jia X, Ding Y, Ji M, Gong W
    Immunology, 2014-03-01;141(3):401-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  133. Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation.
    Authors: Faustino L, Fonseca D, Florsheim E, Resende R, Lepique A, Faquim-Mauro E, Gomes E, Silva J, Yagita H, Russo M
    Mucosal Immunol, 2014-02-26;7(5):1199-208.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  134. Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.
    Authors: Cook J, Carta L, Benard L, Chemaly E, Chiu E, Rao S, Hampton T, Yurchenco P, Costa K, Hajjar R, Ramirez F
    J Clin Invest, 2014-02-17;124(3):1329-39.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  135. Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix.
    Authors: Weaver S, Wolters B, Ito N, Woskowicz A, Kaneko K, Shitomi Y, Seiki M, Itoh Y
    J Cell Sci, 2014-01-24;127(0):1203-13.
    Species: Canine, Human, Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  136. The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-beta.
    Authors: Craft C, Pietka T, Schappe T, Coleman T, Combs M, Klein S, Abumrad N, Mecham R
    Diabetes, 2014-01-23;63(6):1920-32.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  137. Chondrogenesis of Mesenchymal Stem Cells in an Osteochondral Environment Is Mediated by the Subchondral Bone
    Authors: Marloes L. de Vries–van Melle, Roberto Narcisi, Nicole Kops, Wendy J.L.M. Koevoet, P. Koen Bos, J. Mary Murphy et al.
    Tissue Engineering Part A
  138. Biglycan and decorin differentially regulate signaling in the fetal membranes.
    Authors: Wu Z, Horgan C, Carr O, Owens R, Iozzo R, Lechner B
    Matrix Biol, 2013-12-25;35(0):266-75.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  139. A mechanism linking Id2-TGFbeta crosstalk to reversible adaptive plasticity in neuroblastoma.
    Authors: Chakrabarti L, Wang B, Lee N, Sandler A
    PLoS ONE, 2013-12-23;8(12):e83521.
    Species: Mouse
    Sample Types: Cell Culture Supernates, Whole Cells
    Applications: Neutralization, Western Blot
  140. Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
    Authors: Gallo E, Loch D, Habashi J, Calderon J, Chen Y, Bedja D, van Erp C, Gerber E, Parker S, Sauls K, Judge D, Cooke S, Lindsay M, Rouf R, Myers L, ap Rhys C, Kent K, Norris R, Huso D, Dietz H
    J Clin Invest, 2013-12-20;124(1):448-60.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  141. The metalloprotease ADAM12 regulates the effector function of human Th17 cells.
    Authors: Zhou A, El Hed A, Mercer F, Kozhaya L, Unutmaz D
    PLoS ONE, 2013-11-21;8(11):e81146.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  142. TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement.
    Authors: Bialas A, Stevens B
    Nat Neurosci, 2013-10-27;16(12):1773-82.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Immunodepletion
  143. Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vdelta 2 T lymphocytes in non-Hodgkin lymphomas.
    Authors: Musso A, Catellani S, Canevali P, Tavella S, Vene R, Boero S, Pierri I, Gobbi M, Kunkl A, Ravetti J, Zocchi M, Poggi A
    Haematologica, 2013-10-25;99(1):131-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  144. Blood pressure homeostasis is maintained by a P311–TGF-beta axis
    Authors: Kameswara Rao Badri, Ming Yue, Oscar A. Carretero, Sree Latha Aramgam, Jun Cao, Stephen Sharkady et al.
    Journal of Clinical Investigation
  145. Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress.
    Authors: Gandhi N, Su Z, Zhang X, Volpe E, Pelegrino F, Rahman S, Li D, Pflugfelder S, de Paiva C
    J Leukoc Biol, 2013-08-27;94(6):1293-301.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  146. PARP-1 regulates expression of TGF-beta receptors in T cells.
    Authors: Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel J, Maruyama T, Wei G, Abbatiello B, Wang Z, Zhao K, Chen W
    Blood, 2013-08-12;122(13):2224-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  147. TGF-beta Induces Acetylation of Chromatin and of Ets-1 to Alleviate Repression of miR-192 in Diabetic Nephropathy
    Authors: Mitsuo Kato, Varun Dang, Mei Wang, Jung Tak Park, Supriya Deshpande, Swati Kadam et al.
    Science Signaling
  148. CD2-mediated regulation of peripheral CD4(+) CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim.
    Authors: Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H
    Immunology, 2013-05-01;139(1):48-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  149. Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-beta.
    Authors: Yu C, Becker C, Wang Y, Marches F, Helft J, Leboeuf M, Anguiano E, Pourpe S, Goller K, Pascual V, Banchereau J, Merad M, Palucka K
    Immunity, 2013-04-04;38(4):818-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  150. Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture.
    Authors: Nakagawa R, Togawa A, Nagasawa T, Nishikawa S
    J Immunol, 2013-03-04;190(7):3309-18.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  151. Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells.
    Authors: Schreiner J, Kretschmer D, Klenk J, Otto M, Buhring H, Stevanovic S, Wang J, Beer-Hammer S, Peschel A, Autenrieth S
    J Immunol, 2013-03-04;190(7):3417-26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  152. Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity.
    Authors: Norris B, Uebelhoer L, Nakaya H, Price A, Grakoui A, Pulendran B
    Immunity, 2013-02-21;38(2):309-21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  153. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
    Authors: Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, Chen W, Stepkowski S
    J Immunol, 2013-02-20;190(7):3153-62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  154. Loss of muscleblind-like 1 promotes invasive mesenchyme formation in endocardial cushions by stimulating autocrine TGF beta 3
    Authors: Kathryn E LeMasters, Yotam Blech-Hermoni, Samantha J Stillwagon, Natalie A Vajda, Andrea N Ladd
    BMC Developmental Biology
  155. Transforming Growth Factor-Beta Promotes Rhinovirus Replication in Bronchial Epithelial Cells by Suppressing the Innate Immune Response
    Authors: Nicole Bedke, David Sammut, Ben Green, Valia Kehagia, Patrick Dennison, Gisli Jenkins et al.
    PLoS ONE
  156. TGF-beta signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
    Authors: Zhang N, Bevan MJ
    Nat. Immunol., 2012-05-27;13(7):667-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  157. Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta.
    Authors: Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F
    Nature, 2012-04-26;484(7395):514-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  158. Uterine Dysfunction in Biglycan and Decorin Deficient Mice Leads to Dystocia during Parturition
    Authors: Zhiping Wu, Abraham W. Aron, Elyse E. Macksoud, Renato V. Iozzo, Chi-Ming Hai, Beatrice E. Lechner
    PLoS ONE
  159. Ha-Ras stabilization mediates pro-fibrotic signals in dermal fibroblasts
    Authors: Silvia Smaldone, Jacopo Olivieri, Gabriele Luca Gusella, Gianluca Moroncini, Armando Gabrielli, Francesco Ramirez
    Fibrogenesis & Tissue Repair
  160. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.
    Authors: Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KK, Caldwell RW, Su Y
    J. Clin. Invest., 2011-10-17;121(11):4548-66.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-Fr
  161. Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.
    Authors: Montane J, Bischoff L, Soukhatcheva G, Dai DL, Hardenberg G, Levings MK, Orban PC, Kieffer TJ, Tan R, Verchere CB
    J. Clin. Invest., 2011-08-01;121(0):3024.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  162. T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-beta 1 Cytokine
    Authors: Moses K. Donkor, Abira Sarkar, Peter A. Savage, Ruth A. Franklin, Linda K. Johnson, Achim A. Jungbluth et al.
    Immunity
  163. Effect of Fluticasone Furoate on Interleukin 6 Secretion From Adenoid Tissues in Children With Obstructive Sleep Apnea
    Authors: Rania Esteitie, Janaki Emani, Shilpy Sharma, Dana L. Suskind, Fuad M. Baroody
    Archives of Otolaryngology–Head & Neck Surgery
  164. Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance.
    Authors: Chaturvedi V, Collison LW, Guy CS, Workman CJ, Vignali DA
    J. Immunol., 2011-05-16;186(12):6661-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  165. Autocrine Transforming Growth Factor-beta 1 Promotes In Vivo Th17 Cell Differentiation
    Authors: Ilona Gutcher, Moses K. Donkor, Qian Ma, Alexander Y. Rudensky, Richard A. Flavell, Ming O. Li
    Immunity
  166. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
    Authors: Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ
    Mol. Biol. Cell, 2011-03-16;22(10):1686-98.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Neutralization
  167. Epigenetic Histone Methylation Modulates Fibrotic Gene Expression
    Authors: Guangdong Sun, Marpadga A. Reddy, Hang Yuan, Linda Lanting, Mitsuo Kato, Rama Natarajan
    Journal of the American Society of Nephrology
  168. Anti-Asthma Simplified Herbal Medicine Intervention-induced long-lasting tolerance to allergen exposure in an asthma model is interferon-gamma, but not transforming growth factor-beta dependent.
    Authors: Srivastava K, Zhang T, Yang N, Sampson H, Li XM
    Clin. Exp. Allergy, 2010-11-01;40(11):1678-88.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  169. Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells.
    Authors: Tso GH, Law HK, Tu W
    Stem Cells, 2010-05-01;28(5):939-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  170. Stromal regulation of vessel stability by MMP14 and TGFbeta
    Authors: Nor E. Sounni, Kerstin Dehne, Leon van Kempen, Mikala Egeblad, Nesrine I. Affara, Ileana Cuevas et al.
    Disease Models & Mechanisms
  171. Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg
    Authors: Rahul Kushwah, Jing Wu, Jordan R. Oliver, George Jiang, Jinyi Zhang, Katherine A. Siminovitch et al.
    European Journal of Immunology
  172. Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade.
    Authors: Lu H, Wagner WM, Gad E, Yang Y, Duan H, Amon LM, Van Denend N, Larson ER, Chang A, Tufvesson H, Disis ML
    J. Immunol., 2010-03-22;184(9):5360-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  173. Muscleblind-like 1 is a negative regulator of TGF-β-dependent epithelial–mesenchymal transition of atrioventricular canal endocardial cells
    Authors: Natalie A. Vajda, Kyle R. Brimacombe, Kathryn E. LeMasters, Andrea N. Ladd
    Developmental Dynamics
  174. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior.
    Authors: Koo JW, Russo SJ, Ferguson D, Nestler EJ, Duman RS
    Proc. Natl. Acad. Sci. U.S.A., 2010-01-26;107(6):2669-74.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  175. Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1.
    Authors: Linke A, Goren I, Bosl MR, Pfeilschifter J, Frank S
    J. Invest. Dermatol., 2009-11-19;130(3):866-75.
    Species: Mouse
    Sample Types: Cell Lysates, In Vivo
    Applications: Bioassay, Neutralization
  176. Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repair.
    Authors: Prignano F, Campolmi P, Bonan P
    Dermatol Ther, 2009-11-01;22(0):S8-15.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  177. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.
    Authors: Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA
    Nat. Immunol., 2009-08-09;10(9):981-91.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  178. Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta.
    Authors: Han G, Wang R, Chen G
    Immunology, 2009-08-04;129(2):197-206.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  179. The AP-1 transcription factor Batf controls T(H)17 differentiation.
    Authors: Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM
    Nature, 2009-07-05;460(7253):405-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  180. TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
    Authors: Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
    Eur. J. Immunol., 2009-05-01;39(5):1221-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  181. Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues.
    Authors: Vitsky A, Waire J, Pawliuk R, Bond A, Matthews D, Lacasse E, Hawes ML, Nelson C, Richards S, Piepenhagen PA, Garman RD, Andrews L, Thurberg BL, Lonning S, Ledbetter S, Ruzek MC
    Am. J. Pathol., 2009-04-30;174(6):2137-49.
    Applications: Neutralization
  182. Loss of Thy-1 inhibits alveolar development in the newborn mouse lung.
    Authors: Nicola T, Hagood JS, James ML, Macewen MW, Williams TA, Hewitt MM, Schwiebert L, Bulger A, Oparil S, Chen YF, Ambalavanan N
    Am. J. Physiol. Lung Cell Mol. Physiol., 2009-03-06;296(5):L738-50.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  183. Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.
    Authors: Tran DQ, Glass DD, Uzel G, Darnell DA, Spalding C, Holland SM, Shevach EM
    J. Immunol., 2009-03-01;182(5):2929-38.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  184. CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1.
    Authors: Han Y, Guo Q, Zhang M, Chen Z, Cao X
    J. Immunol., 2009-01-01;182(1):111-20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  185. Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor
    Authors: Olav A. Gressner, Birgit Lahme, Monika Siluschek, Katharina Rehbein, Jens Herrmann, Ralf Weiskirchen et al.
    Journal of Cellular and Molecular Medicine
  186. Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling.
    Authors: Pen A, Moreno MJ, Durocher Y, Deb-Rinker P, Stanimirovic DB
    Oncogene, 2008-08-18;27(54):6834-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  187. Molecular mechanisms of TGFbeta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506.
    Authors: Akool el-S, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, Eberhardt W
    J. Immunol., 2008-08-15;181(4):2831-45.
    Species: Rat
    Sample Types: In Vivo
    Applications: Neutralization
  188. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.
    Authors: Carlson ME, Hsu M, Conboy IM
    Nature, 2008-06-15;454(7203):528-32.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Neutralization
  189. Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells.
    Authors: van der Vliet HJ, Wang R, Yue SC, Koon HB, Balk SP, Exley MA
    J. Immunol., 2008-06-01;180(11):7287-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  190. Characterization of naturally occurring CD4+CD25+ regulatory T cells in rhesus monkeys.
    Authors: Haanstra KG, van der Maas MJ, 't Hart BA, Jonker M
    Transplantation, 2008-04-27;85(8):1185-92.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Neutralization
  191. CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.
    Authors: Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W
    Nat. Med., 2008-04-27;14(5):528-35.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  192. Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells.
    Authors: Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, Zitvogel L
    J. Immunol., 2008-04-01;180(7):4679-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  193. Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.
    Authors: Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L
    Am. J. Pathol., 2008-03-18;172(4):1127-40.
    Species: Human, Mink
    Sample Types: Whole Cells
    Applications: Flow Cytometry, Neutralization
  194. Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge.
    Authors: He R, Oyoshi MK, Jin H, Geha RS
    Proc. Natl. Acad. Sci. U.S.A., 2007-09-24;104(40):15817-22.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Neutralization
  195. In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid.
    Authors: Saurer L, McCullough KC, Summerfield A
    J. Immunol., 2007-09-15;179(6):3504-14.
    Species: Porcine
    Sample Types: Cell Culture Supernates, Whole Cells
    Applications: ELISA Development, Neutralization
  196. Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes.
    Authors: Lamar JM, Iyer V, DiPersio CM
    J. Invest. Dermatol., 2007-08-30;128(3):575-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  197. Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses.
    Authors: Alatrakchi N, Graham CS, van der Vliet HJ, Sherman KE, Exley MA, Koziel MJ
    J. Virol., 2007-03-21;81(11):5882-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  198. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
    Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
    Blood, 2007-02-08;109(10):4272-9.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Luminex Development
  199. Long-term staphylococcal enterotoxin C1 exposure induces soluble factor-mediated immunosuppression by bovine CD4+ and CD8+ T cells.
    Authors: Seo KS, Lee SU, Park YH, Davis WC, Fox LK, Bohach GA
    Infect. Immun., 2006-10-09;75(1):260-9.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Neutralization
  200. IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells.
    Authors: Rosendahl AH, Forsberg G
    Kidney Int., 2006-09-13;70(9):1584-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  201. Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
    Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
    Gut, 2006-07-13;56(2):243-52.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: IHC-Fr, Neutralization
  202. Requirement of Smad3 for mast cell growth.
    Authors: Funaba M, Nakaya K, Ikeda T, Murakami M, Tsuchida K, Sugino H
    Cell. Immunol., 2006-07-12;240(1):47-52.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells
    Applications: Neutralization, Western Blot
  203. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct.
    Authors: Maeshima A, Vaughn DA, Choi Y, Nigam SK
    Dev. Biol., 2006-04-27;295(2):473-85.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: Neutralization
  204. Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells.
    Authors: Dasgupta S, Bhattacharya-Chatterjee M, O&amp;apos;Malley BW, Chatterjee SK
    J. Cell. Biochem., 2006-04-01;97(5):1036-51.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr, IHC-P
  205. Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation.
    Authors: Fazzini M, Vallejo G, Colman-Lerner A, Trigo R, Campo S, Baranao JL, Saragueta PE
    J. Cell. Physiol., 2006-04-01;207(1):40-8.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Neutralization
  206. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
    Authors: Neurohr C, Nishimura SL, Sheppard D
    Am. J. Respir. Cell Mol. Biol., 2006-03-30;35(2):252-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  207. Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes.
    Authors: Koelle DM, Huang J, Hensel MT, McClurkan CL
    J. Virol., 2006-03-01;80(6):2863-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  208. Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta.
    Authors: Huang X, Zhu J, Yang Y
    J. Immunol., 2005-10-01;175(7):4283-91.
    Species: Mouse
    Sample Types:
    Applications: Neutralization
  209. Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling.
    Authors: Close JL, Gumuscu B, Reh TA
    Development, 2005-07-01;132(13):3015-26.
    Species: Rat
    Sample Types: In Vivo
    Applications: Neutralization
  210. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
    Authors: Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB
    Blood, 2004-09-16;105(2):750-8.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Neutralization
  211. Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells.
    Authors: Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T
    Immunology, 2004-06-01;112(2):274-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  212. Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates.
    Authors: Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ
    J. Immunol., 2004-05-01;172(9):5753-64.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC-P, Western Blot
  213. P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2.
    Authors: Paliwal S, Shi J, Dhru U, Zhou Y, Schuger L
    Biochem. Biophys. Res. Commun., 2004-03-19;315(4):1104-9.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  214. In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.
    Authors: Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB
    Blood, 2004-03-18;104(2):453-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  215. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.
    Authors: Kitani A, Fuss I, Pedersen A, Nawata H
    J. Immunol., 2004-01-15;172(2):834-42.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  216. IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression.
    Authors: Koenen HJ, Fasse E, Joosten I
    J. Immunol., 2003-12-15;171(12):6431-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  217. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
    Authors: Chen, WanJun, Jin, Wenwen, Hardegen, Neil, Lei, Ke-Jian, Li, Li, Marinos, Nancy, McGrady, George, Wahl, Sharon M
    J Exp Med, 2003-12-15;198(12):1875-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  218. Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice.
    Authors: Kobayashi T, Iijima K, Kita H
    J. Immunol., 2003-06-01;170(11):5756-63.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  219. Immunosuppression in hamsters with progressive visceral leishmaniasis is associated with an impairment of protein kinase C activity in their lymphocytes that can be partially reversed by okadaic acid or anti-transforming growth factor beta antibody.
    Authors: Mookerjee A, Sen PC, Ghose AC
    Infect. Immun., 2003-05-01;71(5):2439-46.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Neutralization
  220. The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure.
    Authors: Feugate JE, 2019, Li Q, Wong L, Martins-Green M
    e0216795, 2002-01-07;156(1):161-72.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Neutralization
  221. Fortilin interacts with TGF-beta 1 and prevents TGF-beta receptor activation
    Authors: Decha Pinkaew, Erik Martinez-Hackert, Wei Jia, Matthew D. King, Fei Miao, Nicole R. Enger et al.
    Communications Biology
  222. Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25‑dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation
    Authors: Gaoyuan Wang, Junqiang Zhang, Yuan Fang, Wei Cao, Bin Xu, Xiaoyu Chen
    Experimental and Therapeutic Medicine
  223. Integration of TGF-beta -induced Smad signaling in the insulin-induced transcriptional response in endothelial cells
    Authors: Erine H. Budi, Steven Hoffman, Shaojian Gao, Ying E. Zhang, Rik Derynck
    Scientific Reports
  224. Age-dependent NK cell dysfunctions in severe COVID-19 patients
    Authors: Cinzia Fionda, Silvia Ruggeri, Giuseppe Sciumè, Mattia Laffranchi, Isabella Quinti, Cinzia Milito et al.
    Frontiers in Immunology
  225. Essential role of microglial transforming growth factor-beta 1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-beta 1
    Authors: Kai Zhang, Chun Yang, Lijia Chang, Akemi Sakamoto, Toru Suzuki, Yuko Fujita et al.
    Translational Psychiatry

FAQs

  1. Can the TGF-beta 1, 2, 3 Antibody, Cat# MAB1835, neutralize the activity of all three TGF-beta proteins?

    • Yes, this antibody can neutralize the activity of TGF-beta 1, 2, and 3 proteins.

View all Antibody FAQs
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TGF-beta 1, 2, 3 Antibody
By Gabriele Strusi on 12/06/2022
Application: WB Sample Tested: HepG2 human hepatocellular carcinoma cell line Species: Human
Western Blot TGF-beta 1, 2, 3 Antibody MAB1835
TGF-beta 1, 2, 3 Antibody
By Anonymous on 08/05/2021
Application: WB Sample Tested: Dermal fibroblasts Species: Mouse
Western Blot TGF-beta 1, 2, 3 Antibody MAB1835
TGF-beta 1, 2, 3 Antibody
By Shatovisha Dey on 10/27/2020
Application: WB Sample Tested: Adult pancreas Species: Mouse
Western Blot TGF-beta 1, 2, 3 Antibody MAB1835
TGF-beta 1, 2, 3 Antibody
By Anonymous on 10/13/2020
Application: WB Sample Tested: Pancreas tissue Species: Mouse
Western Blot TGF-beta 1, 2, 3 Antibody MAB1835
TGF-beta 1, 2, 3 Antibody
By Jenna Nguyen on 07/09/2019
Application: B/N Sample Tested: 3T3-L1 mouse embryonic fibroblast adipose-like cell line Species: Mouse
TGF-beta 1, 2, 3 Antibody
By Anonymous on 04/30/2019
Application: WB Sample Tested: Muscle tissue Species: Mouse
TGF-beta 1, 2, 3 Antibody
By Anonymous on 03/28/2019
Application: ELISA Sample Tested: Recombinant protein Species: Human
ELISA TGF-beta 1, 2, 3 Antibody MAB1835
TGF-beta 1, 2, 3 Antibody
By Anthony Morales on 01/28/2019
Application: WB Sample Tested: Skin cancer tissue Species: Mouse
TGF-beta 1, 2, 3 Antibody
By Anonymous on 05/22/2018
Application: IHC Sample Tested: Tonsil tissue Species: Human
TGF-beta 1, 2, 3 Antibody
By Danlee Enzler on 04/24/2018
Application: IHC Sample Tested: Skin cancer tissue Species: Mouse
TGF-beta 1, 2, 3 Antibody
By Anonymous on 07/21/2017
Application: Immunocytochemistry/Immunofluorescence Sample Tested: A549 human lung carcinoma cell line Species: Human
Immunocytochemistry/Immunofluorescence TGF-beta 1, 2, 3 Antibody MAB1835
TGF-beta 1, 2, 3 Antibody
By Anonymous on 05/16/2017
Application: B/N Sample Tested: Peritoneal macrophages Species: Mouse