Home / Histamine H1 Receptor Antagonists / Terfenadine

Terfenadine

Catalog #: 3948
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3948/50
Terfenadine | CAS No. 50679-08-8 | Histamine H1 Receptor Antagonists
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Description: H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker

Chemical Name: α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol

Purity: ≥98%

Product Details
Citations (5)
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Biological Activity

Terfenadine is a histamine H1 receptor antagonist. Also blocks KV11.1 (hERG) and Kir6 (KATP) channels (IC50 values are 204 nM and 1.2 μM respectively). Inhibits the delayed rectifier K+ current (IKr) in guinea pig ventricular myocytes (IC50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo.

Technical Data

M.Wt:
471.67
Formula:
C32H41NO2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
50679-08-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Terfenadine

The citations listed below are publications that use Tocris products. Selected citations for Terfenadine include:

5 Citations: Showing 1 - 5

  1. Cardioluminescence in Transgenic Zebrafish Larvae: A Calcium Imaging Tool to Study Drug Effects and Pathological Modeling.
    Authors: Masafumi Et al.
    Biomedicines  2021;9
  2. Antihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2.
    Authors: Rui Et al.
    Mol Cancer Ther  2020;19:2023-2033
  3. A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia.
    Authors: Pérez-G?mez Et al.
    Nat Commun  2018;9:5272
  4. Second-generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice.
    Authors: Klingerman Et al.
    Schizophr Bull  2014;40:327
  5. Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.
    Authors: Francis Et al.
    Gut  2012;61:753

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