TC-I 15

Biological Activity

TC-I 15 is a potent α₂β₁ integrin inhibitor (IC₅₀ values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). TC-I 15 displays selectivity for α₂β₁ over α_vβ₃, α₅β₁, α₆β₁ and α_IIbβ₃ at concentrations exceeding 1000 nM. TC-I 15 reduces collagen IV production in mesangial cells. Active in vivo; TC-I 15 prevents ferric chloride-induced clot formation in mice.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Inhibition of integrin α2β1 ameliorates glomerular injury.
   Borza et al.
   J.Am.Soc.Nephrol., 2012;23:1027
2. Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism.
   Miller et al.
   Proc.Natl.Acad.Sci.U.S.A., 2009;106:719

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