TC-DAPK 6
Chemical Name: (4Z)-2-[(E)-2-Phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone
Purity: ≥98%
Biological Activity
TC-DAPK 6 is a potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of death-associated protein kinases inhibitors using structure-based virtual screening.
Okamoto et al.
J.Med.Chem., 2009;52:7323
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Citation for TC-DAPK 6
The citations listed below are publications that use Tocris products. Selected citations for TC-DAPK 6 include:
1 Citation: Showing 1 - 1
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DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease.
Authors: Michael R Et al.
Front Cell Neurosci 2020;14:590569
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