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TASP 0390325

Catalog #: 5729
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5729/10
5729/50
TASP 0390325 | CAS No. 1642187-96-9 | Vasopressin Receptor Antagonists
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Description: Potent and selective V1B receptor antagonist; orally bioavailable

Chemical Name: 2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamide hydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TASP 0390325 is a potent and selective V1B receptor antagonist (IC50 = 2.22 nM for rat pituitary receptor). Exhibits no significant affinity for 85 other receptors, ion channels and transporters at 10 μM, including V1A and V2. Increases ACTH levels in rats. Orally bioavailable. Antidepressant and anxiolytic.

Technical Data

M.Wt:
554.44
Formula:
C25H29ClFN5O4.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1642187-96-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for TASP 0390325

The citations listed below are publications that use Tocris products. Selected citations for TASP 0390325 include:

1 Citation: Showing 1 - 1

  1. Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors.
    Authors: Campos-Lira Et al.
    Front Neurosci  2019;12:919

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