TAPI 0
Chemical Name: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
Purity: ≥95%
Biological Activity
TAPI 0 is an ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 (Cat. No. 2983) to inhibit Chlamydia trachomatis growth.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium.
Balakrishnan et al.
J.Biol.Chem., 2006;281:16691 -
L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro.
Rzeniewicz et al.
Proc.Natl.Acad.Sci.USA., 2015;112:E1461
Product Datasheets
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Citations for TAPI 0
The citations listed below are publications that use Tocris products. Selected citations for TAPI 0 include:
2 Citations: Showing 1 - 2
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Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells.
Authors: Wulf Et al.
Cells 2021;10
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Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity.
Authors: Mina J Et al.
Cell Syst 2020;11:161-175.e5
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Cells were treated with 10 um TAPI-0 to study cell surface protein shedding
